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A4GCL7

- PB1F2_I43A0

UniProt

A4GCL7 - PB1F2_I43A0

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Protein

Protein PB1-F2

Gene
PB1-F2
Organism
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 661Important for pathogenicity, S is highly pathogenic whereas N is low pathogenic By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. modulation by virus of host apoptotic process Source: UniProtKB-KW
  3. suppression by virus of host MAVS activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PB1-F2
Gene namesi
Name:PB1-F2
OrganismiInfluenza A virus (strain A/USA:Iowa/1943 H1N1)
Taxonomic identifieri425563 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008432: Genome

Subcellular locationi

Host mitochondrion inner membrane. Host nucleus. Host cytoplasmhost cytosol
Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol By similarity.

GO - Cellular componenti

  1. host cell cytosol Source: UniProtKB-SubCell
  2. host cell mitochondrial inner membrane Source: UniProtKB-SubCell
  3. host cell nucleus Source: UniProtKB-SubCell
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Protein PB1-F2PRO_0000373016Add
BLAST

Interactioni

Subunit structurei

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliA4GCL7.
SMRiA4GCL7. Positions 50-87.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 8723Mitochondrial targeting sequence By similarityAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view]
PfamiPF11986. PB1-F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4GCL7-1 [UniParc]FASTAAdd to Basket

« Hide

MGQEQDTPWI LSTGHISTQK GEGGQQTPKL EHHNSTRLMG HCQKTMNQVV   50
MPKQIVYWKQ WLSLRNPILV FLKTRVLRRW RLFSKHEWTN 90
Length:90
Mass (Da):10,737
Last modified:April 17, 2007 - v1
Checksum:i09ED1951E0489A5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY020467 Viral cRNA. Translation: ABO38382.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY020467 Viral cRNA. Translation: ABO38382.1 .

3D structure databases

ProteinModelPortali A4GCL7.
SMRi A4GCL7. Positions 50-87.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view ]
Pfami PF11986. PB1-F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. The NIAID Influenza Genome Sequencing Consortium
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPB1F2_I43A0
AccessioniPrimary (citable) accession number: A4GCL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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