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Protein

Protein PB1-F2

Gene

PB1

Organism
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.UniRule annotation

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Low pathogenicityUniRule annotation1

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Protein family/group databases

TCDBi1.A.102.1.1. influenza a viroporin pb1-f2 (pb1-f2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PB1-F2UniRule annotation
Gene namesi
Name:PB1UniRule annotation
Synonyms:PB1-F2
OrganismiInfluenza A virus (strain A/USA:Iowa/1943 H1N1)
Taxonomic identifieri425563 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008432 Componenti: Genome

Subcellular locationi

  • Host mitochondrion inner membrane UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasmhost cytosol UniRule annotation

  • Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003730161 – 90Protein PB1-F2Add BLAST90

Interactioni

Subunit structurei

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4GCL7.
SMRiA4GCL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 87Mitochondrial targeting sequenceUniRule annotationAdd BLAST23

Sequence similaritiesi

Belongs to the influenza viruses PB1-F2 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090001GF.

Family and domain databases

HAMAPiMF_04064. INFV_PB1F2. 1 hit.
InterProiView protein in InterPro
IPR021045. Flu_proapoptotic_PB1-F2.
PfamiView protein in Pfam
PF11986. PB1-F2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4GCL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQEQDTPWI LSTGHISTQK GEGGQQTPKL EHHNSTRLMG HCQKTMNQVV
60 70 80 90
MPKQIVYWKQ WLSLRNPILV FLKTRVLRRW RLFSKHEWTN
Length:90
Mass (Da):10,737
Last modified:April 17, 2007 - v1
Checksum:i09ED1951E0489A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY020467 Viral cRNA. Translation: ABO38382.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPB1F2_I43A0
AccessioniPrimary (citable) accession number: A4GCL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 17, 2007
Last modified: May 10, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families