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A4GCL5

- PA_I43A0

UniProt

A4GCL5 - PA_I43A0

Protein

Polymerase acidic protein

Gene

PA

Organism
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed RNA polymerase activity Source: InterPro

    GO - Biological processi

    1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polymerase acidic protein
    Alternative name(s):
    RNA-directed RNA polymerase subunit P2
    Gene namesi
    Name:PA
    OrganismiInfluenza A virus (strain A/USA:Iowa/1943 H1N1)
    Taxonomic identifieri425563 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008432: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Polymerase acidic proteinPRO_0000372999Add
    BLAST

    Post-translational modificationi

    Phosphorylated on serines and threonines by host kinases, including human casein kinase II.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the influenza viruses PA family.Curated

    Family and domain databases

    InterProiIPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view]
    PfamiPF00603. Flu_PA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform PA (identifier: A4GCL5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD    50
    FHFINEQGES IIVELGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA 100
    EKPKFLPDLY DYKENRFIEI GVTRREVHIY YLEKANKIKS EKTHIHIFSF 150
    TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET 200
    IEERFEITGT MRKLADQSLP PNFSCLENFR AYVDGFEPNG YIEGKLSQMS 250
    KEVNARIEPF LKTTPRPLRL PDGPPCSQRS KFLLMDALKL SIEDPSHEGE 300
    GIPLYDAIKC MRTFFGWKEP NIVKPHEKGI NPNYLLSWKQ LLAELQDIEN 350
    EGKIPKTKNM KKTSQLKWAL GENMAPEKVD FDDCKDVSDL KQYDSDEPEL 400
    RSLSSWIQNE FNKACELTDS IWIELDEIGE DVAPIEHIAS MRRNYFTAEV 450
    SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL 500
    YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY CVLEIGDMLL 550
    RSALGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 600
    SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY 650
    ASPQLEGFSA ESRKLLLIVQ ALRDNLEPGT FDLGGLYEAV EECLINDPWV 700
    LLNASWFNSF LTHALR 716
    Length:716
    Mass (Da):82,613
    Last modified:April 17, 2007 - v1
    Checksum:iFB9404F8964DC107
    GO
    Isoform PA-X (identifier: P0DJW3-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P0DJW3.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:252
    Mass (Da):29,384
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY020466 Viral cRNA. Translation: ABO38380.1.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY020466 Viral cRNA. Translation: ABO38380.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view ]
    Pfami PF00603. Flu_PA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. The NIAID Influenza Genome Sequencing Consortium
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPA_I43A0
    AccessioniPrimary (citable) accession number: A4GCL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3