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A4G8T6 (DDL_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:HEAR2809
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341110

Regions

Domain111 – 315205ATP-grasp
Nucleotide binding141 – 19656ATP By similarity

Sites

Metal binding2681Magnesium or manganese 1 By similarity
Metal binding2821Magnesium or manganese 1 By similarity
Metal binding2821Magnesium or manganese 2 By similarity
Metal binding2841Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4G8T6 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: D433204BAAE28691

FASTA33435,913
        10         20         30         40         50         60 
MTTTVQNLKA EFGKVGVLFG GRSAEREVSL MSGKGVLAAL QSKGVDAHAF DPAERSLAEL 

        70         80         90        100        110        120 
AAEKFDRVFI ALHGSYGEDG TLQGALEQLG IPYTGPGVMA SAISMDKVMT KRVCLSHGVP 

       130        140        150        160        170        180 
TPRFTVLDAE TTSAAQLQSV AAEFGLPLML KAPHEGSTIG IAKVETAEGM QAGFDLCAKY 

       190        200        210        220        230        240 
EAVVLVEQFV KGRELTVPVI GSGRNARALP IVEIRAPQGN YDYEHKYFSN DTEYLCPAPF 

       250        260        270        280        290        300 
DEAFTKRVQA LAVSAFNAVG CTGWSRVDFM VRASDNEPFL LEINTSPGMT SHSLVPMSAK 

       310        320        330 
VAGTGYEDLC IEILRSAKTE LKPSSHMQLQ EQER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU207211 Genomic DNA. Translation: CAL62923.1.
RefSeqYP_001101044.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G8T6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204773.HEAR2809.

Proteomic databases

PRIDEA4G8T6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL62923; CAL62923; HEAR2809.
GeneID4930494.
KEGGhar:HEAR2809.
PATRIC22115568. VBIHerArs17568_2642.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycHARS204773:GJCA-2702-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_HERAR
AccessionPrimary (citable) accession number: A4G8T6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 17, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways