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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARS204773:G1GI6-2492-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HEAR2661
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093531 – 881Leucine--tRNA ligaseAdd BLAST881

Proteomic databases

PRIDEiA4G8E6

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR2661

Structurei

3D structure databases

ProteinModelPortaliA4G8E6
SMRiA4G8E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 58"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4G8E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKYSPADV EKSAHDHWQA TDAYKAVEHA KDKNGKDKKK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN
110 120 130 140 150
VPPAQWTYAN IEHMKTQMAS MGLAIDWSRE MTACKPEYYK WNQWMFLKML
160 170 180 190 200
EKGIIYKKTG SVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR
210 220 230 240 250
ITDYAEELLD HVEHKLPGWP ERVRTMQANW IGKSTGVRFA FTHDIKDDDK
260 270 280 290 300
LINDGKLWVF TTRADTIKGV TFCAVAAEHP LATFAAKSNP ELAEFIAECK
310 320 330 340 350
LGSVIEADMA TMEKKGMPTG LFVKHPLTGS LVEVWVGNYV LITYGDGAVM
360 370 380 390 400
GVPAHDERDF AFAQKYVLPI HQVIDVEGKT FSEVTWHDWY ADKENGRCIN
410 420 430 440 450
SGKYDGLNYQ QAVNTIAADL EELGLGEKKI TYRLRDWGIS RQRYWGTPIP
460 470 480 490 500
MINCADCGAV PVPEKDLPVV LPEDCVPDGS GNPLNKHEAF LKCDCPKCGK
510 520 530 540 550
PARRETDTMD TFVDSSWYYM RYCSPNSNDA MVDSRNDYWM PMDQYIGGIE
560 570 580 590 600
HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYYREDASGK
610 620 630 640 650
KTWFNPADVQ LELDDKGRPV SAILNNDRQP VEIGGTEKMS KSKNNGIDPQ
660 670 680 690 700
AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWTYAYNQS
710 720 730 740 750
ARIAAATASD FSKLSDAQKT LRREVHKILQ QADNDYKRIQ YNTVVSAGMK
760 770 780 790 800
MLNTLEGAKL DESAASNAVI AEGLSIFLRI LNPVAPHITH VLWQELGFAK
810 820 830 840 850
VHGDILDAAW PQVDAGALEQ AEIEMMIQVN GKLRGSIVVA KDADKATIEA
860 870 880
TALANEAVRK FIEGTPKKII VVPGKLVNIV A
Length:881
Mass (Da):99,183
Last modified:April 17, 2007 - v1
Checksum:i643783A2A205F7A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA Translation: CAL62783.1
RefSeqiWP_011872041.1, NC_009138.1

Genome annotation databases

EnsemblBacteriaiCAL62783; CAL62783; HEAR2661
KEGGihar:HEAR2661

Entry informationi

Entry nameiSYL_HERAR
AccessioniPrimary (citable) accession number: A4G8E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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