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A4G8E6 (SYL_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:HEAR2661
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas

Protein attributes

Sequence length881 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 881881Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009353

Regions

Motif48 – 5811"HIGH" region HAMAP-Rule MF_00049
Motif638 – 6425"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6411ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4G8E6 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 643783A2A205F7A7

FASTA88199,183
        10         20         30         40         50         60 
MQDKYSPADV EKSAHDHWQA TDAYKAVEHA KDKNGKDKKK FYACSMLPYP SGKLHMGHVR 

        70         80         90        100        110        120 
NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN VPPAQWTYAN IEHMKTQMAS 

       130        140        150        160        170        180 
MGLAIDWSRE MTACKPEYYK WNQWMFLKML EKGIIYKKTG SVNWDPIDQT VLANEQVIDG 

       190        200        210        220        230        240 
RGWRSGALIE KREIPMYYAR ITDYAEELLD HVEHKLPGWP ERVRTMQANW IGKSTGVRFA 

       250        260        270        280        290        300 
FTHDIKDDDK LINDGKLWVF TTRADTIKGV TFCAVAAEHP LATFAAKSNP ELAEFIAECK 

       310        320        330        340        350        360 
LGSVIEADMA TMEKKGMPTG LFVKHPLTGS LVEVWVGNYV LITYGDGAVM GVPAHDERDF 

       370        380        390        400        410        420 
AFAQKYVLPI HQVIDVEGKT FSEVTWHDWY ADKENGRCIN SGKYDGLNYQ QAVNTIAADL 

       430        440        450        460        470        480 
EELGLGEKKI TYRLRDWGIS RQRYWGTPIP MINCADCGAV PVPEKDLPVV LPEDCVPDGS 

       490        500        510        520        530        540 
GNPLNKHEAF LKCDCPKCGK PARRETDTMD TFVDSSWYYM RYCSPNSNDA MVDSRNDYWM 

       550        560        570        580        590        600 
PMDQYIGGIE HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYYREDASGK 

       610        620        630        640        650        660 
KTWFNPADVQ LELDDKGRPV SAILNNDRQP VEIGGTEKMS KSKNNGIDPQ AQIDQYGADT 

       670        680        690        700        710        720 
ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWTYAYNQS ARIAAATASD FSKLSDAQKT 

       730        740        750        760        770        780 
LRREVHKILQ QADNDYKRIQ YNTVVSAGMK MLNTLEGAKL DESAASNAVI AEGLSIFLRI 

       790        800        810        820        830        840 
LNPVAPHITH VLWQELGFAK VHGDILDAAW PQVDAGALEQ AEIEMMIQVN GKLRGSIVVA 

       850        860        870        880 
KDADKATIEA TALANEAVRK FIEGTPKKII VVPGKLVNIV A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU207211 Genomic DNA. Translation: CAL62783.1.
RefSeqYP_001100904.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G8E6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204773.HEAR2661.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL62783; CAL62783; HEAR2661.
GeneID4929858.
KEGGhar:HEAR2661.
PATRIC22115280. VBIHerArs17568_2499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycHARS204773:GJCA-2563-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_HERAR
AccessionPrimary (citable) accession number: A4G8E6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries