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A4G8E6

- SYL_HERAR

UniProt

A4G8E6 - SYL_HERAR

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Protein

Leucine--tRNA ligase

Gene
leuS, HEAR2661
Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARS204773:GJCA-2563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:HEAR2661
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
ProteomesiUP000006697: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Leucine--tRNA ligaseUniRule annotationPRO_1000009353Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR2661.

Structurei

3D structure databases

ProteinModelPortaliA4G8E6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotationAdd
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G8E6-1 [UniParc]FASTAAdd to Basket

« Hide

MQDKYSPADV EKSAHDHWQA TDAYKAVEHA KDKNGKDKKK FYACSMLPYP    50
SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN 100
VPPAQWTYAN IEHMKTQMAS MGLAIDWSRE MTACKPEYYK WNQWMFLKML 150
EKGIIYKKTG SVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR 200
ITDYAEELLD HVEHKLPGWP ERVRTMQANW IGKSTGVRFA FTHDIKDDDK 250
LINDGKLWVF TTRADTIKGV TFCAVAAEHP LATFAAKSNP ELAEFIAECK 300
LGSVIEADMA TMEKKGMPTG LFVKHPLTGS LVEVWVGNYV LITYGDGAVM 350
GVPAHDERDF AFAQKYVLPI HQVIDVEGKT FSEVTWHDWY ADKENGRCIN 400
SGKYDGLNYQ QAVNTIAADL EELGLGEKKI TYRLRDWGIS RQRYWGTPIP 450
MINCADCGAV PVPEKDLPVV LPEDCVPDGS GNPLNKHEAF LKCDCPKCGK 500
PARRETDTMD TFVDSSWYYM RYCSPNSNDA MVDSRNDYWM PMDQYIGGIE 550
HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYYREDASGK 600
KTWFNPADVQ LELDDKGRPV SAILNNDRQP VEIGGTEKMS KSKNNGIDPQ 650
AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWTYAYNQS 700
ARIAAATASD FSKLSDAQKT LRREVHKILQ QADNDYKRIQ YNTVVSAGMK 750
MLNTLEGAKL DESAASNAVI AEGLSIFLRI LNPVAPHITH VLWQELGFAK 800
VHGDILDAAW PQVDAGALEQ AEIEMMIQVN GKLRGSIVVA KDADKATIEA 850
TALANEAVRK FIEGTPKKII VVPGKLVNIV A 881
Length:881
Mass (Da):99,183
Last modified:April 17, 2007 - v1
Checksum:i643783A2A205F7A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL62783.1.
RefSeqiWP_011872041.1. NC_009138.1.
YP_001100904.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL62783; CAL62783; HEAR2661.
GeneIDi4929858.
KEGGihar:HEAR2661.
PATRICi22115280. VBIHerArs17568_2499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL62783.1 .
RefSeqi WP_011872041.1. NC_009138.1.
YP_001100904.1. NC_009138.1.

3D structure databases

ProteinModelPortali A4G8E6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204773.HEAR2661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL62783 ; CAL62783 ; HEAR2661 .
GeneIDi 4929858.
KEGGi har:HEAR2661.
PATRICi 22115280. VBIHerArs17568_2499.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HARS204773:GJCA-2563-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiSYL_HERAR
AccessioniPrimary (citable) accession number: A4G8E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi