Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4G865 (SERC_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase
EC=2.6.1.52
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name=PSAT
Gene names
Name:serC
Ordered Locus Names:HEAR2580
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Herminiimonas

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP MF_00160

Catalytic activity

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP MF_00160

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP MF_00160

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_00160

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP MF_00160

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP MF_00160

Subunit structure

Homodimer By similarity. HAMAP MF_00160

Subcellular location

Cytoplasm By similarity HAMAP MF_00160.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Phosphoserine aminotransferase HAMAP MF_00160
PRO_1000118179

Regions

Region240 – 2412Pyridoxal phosphate binding By similarity

Sites

Binding site421L-glutamate By similarity
Binding site1051Pyridoxal phosphate By similarity
Binding site1551Pyridoxal phosphate By similarity
Binding site1751Pyridoxal phosphate By similarity
Binding site1981Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4G865 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 4DD9F0005E806782

FASTA36340,067
        10         20         30         40         50         60 
MKRVFNFSPG PAAIPQEVIQ QAADEMANWR GCGLSVMEMS HRGREFTEIL ATTKDDLRSL 

        70         80         90        100        110        120 
MSIPDNYKIL LMQGGAIAEN AIVPMNLVGM KPQPATIDFV NTGHWSIKSI EEARKYANVN 

       130        140        150        160        170        180 
VAASSEDQNF TYVPARDTWK LTPDAAYVHV CTNETIGGVE FDFTPDVGNV PLVADMSSNI 

       190        200        210        220        230        240 
LSREIDVSRY AVIYAGAQKN IGPAGLTIVI VRDDMLGHAL PICPSAFDWK LVAEHDSMFN 

       250        260        270        280        290        300 
TPPTYPIYIA GLTFQWMKRQ GGVAAMEKVN IAKAKLLYDY LDSTDFYVNN VPAANRSRMN 

       310        320        330        340        350        360 
VPFFLRDASL NTKFLTEAGQ NDLVQLKGHS SVGGMRASIY NAMPIEGVQA LVDFMKAFEK 


KYG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU207211 Genomic DNA. Translation: CAL62702.1.
RefSeqYP_001100823.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G865.
SMRA4G865. Positions 3-363.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4G865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4932383.
GenomeReviewsGene locus HEAR2580 in contig CU207211_GR.
KEGGhar:HEAR2580.
NMPDRfig|204773.3.peg.2454.
PATRIC22115120. VBIHerArs17568_2419.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1932.
HOGENOMHBG289982.
OMAYEVLFLQ.
PhylomeDBA4G865.
ProtClustDBPRK05355.

Enzyme and pathway databases

BioCycHARS204773:HEAR2580-MONOMER.

Family and domain databases

HAMAPMF_00160. SerC_aminotrans_5.
[Tree]
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00831.
PANTHERPTHR21152:SF1. PTHR21152:SF1. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01364. SerC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSERC_HERAR
AccessionPrimary (citable) accession number: A4G865
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents