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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi421Magnesium 1UniRule annotation1
Metal bindingi428Magnesium 1UniRule annotation1
Metal bindingi428Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARS204773:G1GI6-2089-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:HEAR2230
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000128781 – 511Lysine--tRNA ligaseAdd BLAST511

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204773.HEAR2230

Structurei

3D structure databases

ProteinModelPortaliA4G778
SMRiA4G778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
HOGENOMiHOG000236578
KOiK04567
OMAiMMNIIPG
OrthoDBiPOG091H0098

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

A4G778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHNDDAAA SLPIDENKII AERRAKLSAL REQGIAFPND FRPQHKAADL
60 70 80 90 100
QEKYGSKTRE ELEAEPVTVV LAGRMMLKRE AGKKAAFATL QDASGSKADG
110 120 130 140 150
RIQIYVTLNL TGEAAMAALH HYDLGDILGV SGTLFKTKTD ELTIKVSELR
160 170 180 190 200
LITKSLRPLP DKFHGLADQE TKYRQRYVDL IMNEDTRRTF KARTAAISSI
210 220 230 240 250
RRFMERNDFM EVETPMLHTI PGGAAAKPFT THHNALDMEM FLRIAPELYL
260 270 280 290 300
KRLVVGGFDR VFEINRNFRN EGVSIRHNPE FTMMEFYAAY TDYKWLMDFT
310 320 330 340 350
EAVIRQAAID AHGTATLTYG GRELDLAKPF HRLTIVGAIN KFAPQYTHEQ
360 370 380 390 400
LHDAEYIKAE LKKFGVKPHA HSGLGALQLA LFEETAEAQL WEPTYIIDYP
410 420 430 440 450
VEVSPLARAS DTVAGITERF ELFMVGREIA NGFSELNDAE DQAARFQAQV
460 470 480 490 500
AAKDAGDEEA MYYDADYIRA LEYGMPPTGG CGIGIDRLMM IITDSPNIRD
510
VLLFPHLRRE D
Length:511
Mass (Da):57,531
Last modified:April 17, 2007 - v1
Checksum:i03AA2433E962064F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA Translation: CAL62365.1
RefSeqiWP_011871635.1, NC_009138.1

Genome annotation databases

EnsemblBacteriaiCAL62365; CAL62365; HEAR2230
KEGGihar:HEAR2230

Similar proteinsi

Entry informationi

Entry nameiSYK_HERAR
AccessioniPrimary (citable) accession number: A4G778
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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