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A4G778

- SYK_HERAR

UniProt

A4G778 - SYK_HERAR

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    Cofactori

    Binds 3 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi421 – 4211Magnesium 1UniRule annotation
    Metal bindingi428 – 4281Magnesium 1UniRule annotation
    Metal bindingi428 – 4281Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHARS204773:GJCA-2147-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Short name:
    LysRSUniRule annotation
    Gene namesi
    Name:lysSUniRule annotation
    Ordered Locus Names:HEAR2230
    OrganismiHerminiimonas arsenicoxydans
    Taxonomic identifieri204773 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
    ProteomesiUP000006697: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Lysine--tRNA ligasePRO_1000012878Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204773.HEAR2230.

    Structurei

    3D structure databases

    ProteinModelPortaliA4G778.
    SMRiA4G778. Positions 14-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1190.
    HOGENOMiHOG000236578.
    KOiK04567.
    OMAiAMHFDAD.
    OrthoDBiEOG69PQ2M.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00252. Lys_tRNA_synth_class2.
    InterProiIPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view]
    PANTHERiPTHR22594. PTHR22594. 1 hit.
    PfamiPF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    PRINTSiPR00982. TRNASYNTHLYS.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4G778-1 [UniParc]FASTAAdd to Basket

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    MTTHNDDAAA SLPIDENKII AERRAKLSAL REQGIAFPND FRPQHKAADL    50
    QEKYGSKTRE ELEAEPVTVV LAGRMMLKRE AGKKAAFATL QDASGSKADG 100
    RIQIYVTLNL TGEAAMAALH HYDLGDILGV SGTLFKTKTD ELTIKVSELR 150
    LITKSLRPLP DKFHGLADQE TKYRQRYVDL IMNEDTRRTF KARTAAISSI 200
    RRFMERNDFM EVETPMLHTI PGGAAAKPFT THHNALDMEM FLRIAPELYL 250
    KRLVVGGFDR VFEINRNFRN EGVSIRHNPE FTMMEFYAAY TDYKWLMDFT 300
    EAVIRQAAID AHGTATLTYG GRELDLAKPF HRLTIVGAIN KFAPQYTHEQ 350
    LHDAEYIKAE LKKFGVKPHA HSGLGALQLA LFEETAEAQL WEPTYIIDYP 400
    VEVSPLARAS DTVAGITERF ELFMVGREIA NGFSELNDAE DQAARFQAQV 450
    AAKDAGDEEA MYYDADYIRA LEYGMPPTGG CGIGIDRLMM IITDSPNIRD 500
    VLLFPHLRRE D 511
    Length:511
    Mass (Da):57,531
    Last modified:April 17, 2007 - v1
    Checksum:i03AA2433E962064F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL62365.1.
    RefSeqiWP_011871635.1. NC_009138.1.
    YP_001100488.1. NC_009138.1.

    Genome annotation databases

    EnsemblBacteriaiCAL62365; CAL62365; HEAR2230.
    GeneIDi4932131.
    KEGGihar:HEAR2230.
    PATRICi22114474. VBIHerArs17568_2101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL62365.1 .
    RefSeqi WP_011871635.1. NC_009138.1.
    YP_001100488.1. NC_009138.1.

    3D structure databases

    ProteinModelPortali A4G778.
    SMRi A4G778. Positions 14-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204773.HEAR2230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL62365 ; CAL62365 ; HEAR2230 .
    GeneIDi 4932131.
    KEGGi har:HEAR2230.
    PATRICi 22114474. VBIHerArs17568_2101.

    Phylogenomic databases

    eggNOGi COG1190.
    HOGENOMi HOG000236578.
    KOi K04567.
    OMAi AMHFDAD.
    OrthoDBi EOG69PQ2M.

    Enzyme and pathway databases

    BioCyci HARS204773:GJCA-2147-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00252. Lys_tRNA_synth_class2.
    InterProi IPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view ]
    PANTHERi PTHR22594. PTHR22594. 1 hit.
    Pfami PF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    PRINTSi PR00982. TRNASYNTHLYS.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ULPAs1.

    Entry informationi

    Entry nameiSYK_HERAR
    AccessioniPrimary (citable) accession number: A4G778
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3