Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4G778

- SYK_HERAR

UniProt

A4G778 - SYK_HERAR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg(2+) ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi421 – 4211Magnesium 1UniRule annotation
Metal bindingi428 – 4281Magnesium 1UniRule annotation
Metal bindingi428 – 4281Magnesium 2UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARS204773:GJCA-2147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:HEAR2230
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
ProteomesiUP000006697: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Lysine--tRNA ligasePRO_1000012878Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204773.HEAR2230.

Structurei

3D structure databases

ProteinModelPortaliA4G778.
SMRiA4G778. Positions 14-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1190.
HOGENOMiHOG000236578.
KOiK04567.
OMAiAMHFDAD.
OrthoDBiEOG69PQ2M.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G778-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTHNDDAAA SLPIDENKII AERRAKLSAL REQGIAFPND FRPQHKAADL
60 70 80 90 100
QEKYGSKTRE ELEAEPVTVV LAGRMMLKRE AGKKAAFATL QDASGSKADG
110 120 130 140 150
RIQIYVTLNL TGEAAMAALH HYDLGDILGV SGTLFKTKTD ELTIKVSELR
160 170 180 190 200
LITKSLRPLP DKFHGLADQE TKYRQRYVDL IMNEDTRRTF KARTAAISSI
210 220 230 240 250
RRFMERNDFM EVETPMLHTI PGGAAAKPFT THHNALDMEM FLRIAPELYL
260 270 280 290 300
KRLVVGGFDR VFEINRNFRN EGVSIRHNPE FTMMEFYAAY TDYKWLMDFT
310 320 330 340 350
EAVIRQAAID AHGTATLTYG GRELDLAKPF HRLTIVGAIN KFAPQYTHEQ
360 370 380 390 400
LHDAEYIKAE LKKFGVKPHA HSGLGALQLA LFEETAEAQL WEPTYIIDYP
410 420 430 440 450
VEVSPLARAS DTVAGITERF ELFMVGREIA NGFSELNDAE DQAARFQAQV
460 470 480 490 500
AAKDAGDEEA MYYDADYIRA LEYGMPPTGG CGIGIDRLMM IITDSPNIRD
510
VLLFPHLRRE D
Length:511
Mass (Da):57,531
Last modified:April 17, 2007 - v1
Checksum:i03AA2433E962064F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL62365.1.
RefSeqiWP_011871635.1. NC_009138.1.
YP_001100488.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL62365; CAL62365; HEAR2230.
GeneIDi4932131.
KEGGihar:HEAR2230.
PATRICi22114474. VBIHerArs17568_2101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL62365.1 .
RefSeqi WP_011871635.1. NC_009138.1.
YP_001100488.1. NC_009138.1.

3D structure databases

ProteinModelPortali A4G778.
SMRi A4G778. Positions 14-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204773.HEAR2230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL62365 ; CAL62365 ; HEAR2230 .
GeneIDi 4932131.
KEGGi har:HEAR2230.
PATRICi 22114474. VBIHerArs17568_2101.

Phylogenomic databases

eggNOGi COG1190.
HOGENOMi HOG000236578.
KOi K04567.
OMAi AMHFDAD.
OrthoDBi EOG69PQ2M.

Enzyme and pathway databases

BioCyci HARS204773:GJCA-2147-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00252. Lys_tRNA_synth_class2.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR00982. TRNASYNTHLYS.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiSYK_HERAR
AccessioniPrimary (citable) accession number: A4G778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3