A4G646 (TPIS_HERAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	HEAR1828

Organism

Herminiimonas arsenicoxydans [Complete proteome] [HAMAP]

Taxonomic identifier

204773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Herminiimonas

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Triosephosphate isomerase HAMAP-Rule MF_00147		PRO_0000307481
Sites
	Active site	94	1	Electrophile By similarity
	Active site	166	1	Proton acceptor By similarity
	Binding site	9	1	Substrate By similarity
	Binding site	11	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4G646 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 8F241F52CE1379AF	FASTA	248	26,283
	10 20 30 40 50 60 MRRKLVAGNW KMNGSLAANA LLLAEIKAEF GNPACDVAVC VPAPYLAQCL SLLSDSTIAL 70 80 90 100 110 120 GAQDVSSHDS GAYTGEVSTA MLLEFACRYV IVGHSERRAY FGETNELVAQ KTVRALSAGL 130 140 150 160 170 180 MPIVCVGETL EQREAGQTDE VVGRQIDAVL SSIAENDLAK IVVAYEPVWA IGTGKTATPE 190 200 210 220 230 240 MAQEVHVMLR RRLHAKNAQA ATEVRILYGG SMKPDNAKEL LAMPDIDGGL IGGAALKAAD FLAIIRAA

References

[1]

"A tale of two oxidation states: bacterial colonization of arsenic-rich environments." Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E., Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M., Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E., Lieutaud A. , Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P., Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B., Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J., Lett M.-C., Danchin A., Bertin P.N. PLoS Genet. 3:518-530(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ULPAs1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207211 Genomic DNA. Translation: CAL61983.1.
RefSeq	YP_001100108.1. NC_009138.1.
3D structure databases
ProteinModelPortal	A4G646.
ModBase	Search...
Protein-protein interaction databases
STRING	204773.HEAR1828.
Proteomic databases
PRIDE	A4G646.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL61983; CAL61983; HEAR1828.
GeneID	4931353.
KEGG	har:HEAR1828.
PATRIC	22113722. VBIHerArs17568_1730.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HOG000226413.
KO	K01803.
OMA	ANTVIAY.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	HARS204773:GJCA-1766-MONOMER.
UniPathway	UPA00109; UER00189. UPA00138.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00147_B. TIM_B.
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
PANTHER	PTHR21139. PTHR21139. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_HERAR

Accession

Primary (citable) accession number: A4G646

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program