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Protein

Malate dehydrogenase

Gene

mdh

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Binding sitei101SubstrateUniRule annotation1
Binding sitei108NADUniRule annotation1
Binding sitei115NADUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei190Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi132 – 134NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciHARS204773:G1GI6-1663-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:HEAR1780
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000686031 – 329Malate dehydrogenaseAdd BLAST329

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR1780

Structurei

3D structure databases

ProteinModelPortaliA4G5Z9
SMRiA4G5Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.101 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

A4G5Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAPMRVAV TGAAGQIGYS LLFRIANGDL LGKDQPVILQ LLEIDNEKAQ
60 70 80 90 100
NALKGVIMEI DDCAFPLLAG VSAHSDPMTA FKDVDIALLV GARPRGPGME
110 120 130 140 150
RKDLLEANAQ IFTVQGKALD AVASRNVKVL VVGNPANTNA YIAMKSAPNL
160 170 180 190 200
PAKNFTAMLR LDHNRALSQI AAKTGKPVTA IEKLTVWGNH SPTMYPDYRF
210 220 230 240 250
ATIDGKSVKE AINDEVWNKD VFLPTVGKRG AAIIEARGVS SAASAANAAI
260 270 280 290 300
DHVRDWVLGT NGKWVTMGIP SDGSYGIPKD TMFGFPVTTE NGEYKIVQGL
310 320
EIDAFSQERI NLTLKELSEE REGVKHLLA
Length:329
Mass (Da):35,365
Last modified:April 17, 2007 - v1
Checksum:iC2337E4EA65B698D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA Translation: CAL61936.1
RefSeqiWP_011871263.1, NC_009138.1

Genome annotation databases

EnsemblBacteriaiCAL61936; CAL61936; HEAR1780
KEGGihar:HEAR1780

Similar proteinsi

Entry informationi

Entry nameiMDH_HERAR
AccessioniPrimary (citable) accession number: A4G5Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome