A4G5V5 (MSRB_HERAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	HEAR1736

Organism

Herminiimonas arsenicoxydans [Complete proteome] [HAMAP]

Taxonomic identifier

204773 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Herminiimonas

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000215173
Sites
	Active site	120	1	Nucleophile By similarity
	Metal binding	48	1	Zinc By similarity
	Metal binding	51	1	Zinc By similarity
	Metal binding	97	1	Zinc By similarity
	Metal binding	100	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4G5V5 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: E16E33BC17F78D11	FASTA	137	15,440
	10 20 30 40 50 60 MTEKVIKTDA EWRAMLDDEE YDVTRHAATE APFSGRYWDH HEHGIYTCVC CNTPLFASDA 70 80 90 100 110 120 KFDSGCGWPS YFTALNPDNV KEKIDRAYGM IRTEVICNVC DAHLGHVFND GPPPTGLRYC 130 INSASLRFDA TPDLNES

References

[1]

"A tale of two oxidation states: bacterial colonization of arsenic-rich environments." Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E., Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M., Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E., Lieutaud A. , Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P., Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B., Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J., Lett M.-C., Danchin A., Bertin P.N. PLoS Genet. 3:518-530(2007) [PubMed: 17432936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ULPAs1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207211 Genomic DNA. Translation: CAL61892.1.
RefSeq	YP_001100017.1. NC_009138.1.
3D structure databases
ProteinModelPortal	A4G5V5.
SMR	A4G5V5. Positions 4-130.
ModBase	Search...
Protein-protein interaction databases
STRING	A4G5V5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4931276.
GenomeReviews	Gene locus HEAR1736 in contig CU207211_GR.
KEGG	har:HEAR1736.
NMPDR	fig|204773.3.peg.1648.
PATRIC	22113520. VBIHerArs17568_1635.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	YNDINDK.
PhylomeDB	A4G5V5.
ProtClustDB	CLSK952570.
Enzyme and pathway databases
BioCyc	HARS204773:HEAR1736-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_HERAR

Accession

Primary (citable) accession number: A4G5V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program