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A4G3L8 (ACSA_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene names
Name:acsA
Ordered Locus Names:HEAR0921
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Herminiimonas

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_1000065294

Sites

Active site5301 By similarity

Amino acid modifications

Modified residue6251N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4G3L8 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 7193FB792A35A918

FASTA66072,856
        10         20         30         40         50         60 
MSSIESFKQE GRVFDSPVDF VNNAAISGME AYRALCAEAA DDYEGFWARL AQQNLHWTKP 

        70         80         90        100        110        120 
FTKKLDESNA PFYKWFEDGE LNVSWNCLDR HLHNGNADKV AIIFEADDGN VTRITYKELH 

       130        140        150        160        170        180 
ERVCKFANGL KSLSINKGDR VIIYMPMSID GIAAMQACAR IGATHSVVFG GFSAKSLHER 

       190        200        210        220        230        240 
IIDAGAVAVL TADYQVRGGK NLPLKAIVDE ALAMGGCDTI RNVVVYKRTG GAVDFVERRD 

       250        260        270        280        290        300 
IWLHELVEQR TSECAPEPVG AEHPLFILYT SGSTGKPKGV QHSSAGYLLW AMLTMKWVFD 

       310        320        330        340        350        360 
IKPNDVYWCT ADIGWVTGHT YVTYGPLAVG ATQIVFEGVP MYPNAGRFWE MVQKHKVSIF 

       370        380        390        400        410        420 
YTAPTAIRSL IKAAEADPST HPSKYDLSSL RLLGSVGEPI NPEAWMWYYK NIGGERCPIV 

       430        440        450        460        470        480 
DTFWQTETGG HVISPLPGAT PMVPGSCTLP LPGIIAAVVD DGGHDLPNGK GGLLVIKRPW 

       490        500        510        520        530        540 
PAMIRNIWND PERFEKSYFP HELGGRTYLA GDGAIRNEET GYFTITGRID DVLNISGHRM 

       550        560        570        580        590        600 
GTAEIESALV ANPMVAEAAV VGKPDETTGE SICAFVVLKR VRPEGDEAKQ IAKELRDWVA 

       610        620        630        640        650        660 
KEIGPIAKPK EIRFGDNLPK TRSGKIMRRL LRVLAKDEDI TQDISTLENP AILEQLKQAQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU207211 Genomic DNA. Translation: CAL61105.1.
RefSeqYP_001099232.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G3L8.
SMRA4G3L8. Positions 17-659.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4G3L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4932348.
GenomeReviewsGene locus HEAR0921 in contig CU207211_GR.
KEGGhar:HEAR0921.
NMPDRfig|204773.3.peg.863.
PATRIC22111940. VBIHerArs17568_0853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAHEERIHA.
PhylomeDBA4G3L8.
ProtClustDBPRK00174.

Enzyme and pathway databases

BioCycHARS204773:HEAR0921-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_HERAR
AccessionPrimary (citable) accession number: A4G3L8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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