A4G2X2 (A4G2X2_HERAR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902 EMBL CAL60859.1
Ordered Locus Names:	HEAR0663

Organism

Herminiimonas arsenicoxydans [Complete proteome] [HAMAP]

Taxonomic identifier

204773 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Herminiimonas

Protein attributes

Sequence length	1045 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4G2X2 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 1AF303E397DF06A2	FASTA	1,045	117,821
	10 20 30 40 50 60 MPPFLPAYAE LHCRSNFTFL QGASHPEELV QRACDLGYDS LAITDECSLA GVVRAYVEAK 70 80 90 100 110 120 KHNLHLIIGS DITLSCGTRL VFLATNRNGY GNLSELITLG RRRADKGFYT LHRSDLDPDE 130 140 150 160 170 180 RQEPNSIHLA QLPDCLAILI PKCCCSREEI ARQAAWLART FVGRAWVAAE LLHWSDDEYW 190 200 210 220 230 240 LDLLTGIAAE MDLPLVATGD VLMHVRSRKP LQDTLTAVRL GKSVAECGMD LQPNAEQHLR 250 260 270 280 290 300 SRLRLAQLYS PELLQETLTL AKLCTFSLDE LRYQYPEEIV PAGETLSSYL RRLTYEGATQ 310 320 330 340 350 360 RRFRQGIPAN IRQQIEHELV LITELNYEPF FLTVYDIVKF ARSKGILCQG RGSAANSVVC 370 380 390 400 410 420 YCLGITEVDP ARSSVLFERF ISRERNEPPD IDVDFEHQRR EEVIQYIYNK YGRHRAALTA 430 440 450 460 470 480 ALITYRPRSA MKDVGKALGL DFEQVNRLSQ SHKWWDGREI SDERLQEGGF DPQAPIVQKL 490 500 510 520 530 540 VELTKTLIGF PRHLSQHTGG FVIARDSLAR LVPIENASMK DRSVIEWDKD DLDALGLLKV 550 560 570 580 590 600 DVLALGMLSA IQRALEMIST RRGRMVEMQD IPSEDPLTYE MISAADTIGV FQIESRAQMS 610 620 630 640 650 660 MLPRLRPQKY YDLVVQVAIV RPGPIQGGMV HPYLKQRHMH PDDIVYPGPE IKEALSRTFG 670 680 690 700 710 720 VPIFQEQVMQ IAVLAAGYTP GEADELRRSM AAWKRKGNLE KHGDKLKKGL AKNGYDPEFA 730 740 750 760 770 780 NRLFEQIKGF GEYGFPESHA ASFALLVYVS AWIKRHEPAA FLAALLNSQP MGFYSASQLV 790 800 810 820 830 840 QDAKRHGVPV RPIDVLISEL ESTMEDIHER YPAVRLGLHM VKGLSLDGAK RIIEARAHQS 850 860 870 880 890 900 FKDVDDLARR AELDQHELGA LARANALLPL SGHRRQAKWE VAAMMSAPML LRDAPIREEP 910 920 930 940 950 960 LLLPAASEGQ EIVADYASTG LTLNRHPLAL LRPRLKKMNL STALEMKGFA DRKIARTTGI 970 980 990 1000 1010 1020 VTMRQRPPTA KGTMFVTLED ETGITNVIIW PALVEKQRKE ILNSQLMTVY GIWQCKEEVR 1030 1040 HLVAKRIVDH SELLGDLSVS SRDFQ

References

[1]

"A tale of two oxidation states: bacterial colonization of arsenic-rich environments." Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E., Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M., Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E., Lieutaud A. , Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P., Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B., Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J., Lett M.-C., Danchin A., Bertin P.N. PLoS Genet. 3:518-530(2007) [PubMed: 17432936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ULPAs1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207211 Genomic DNA. Translation: CAL60859.1.
RefSeq	YP_001098986.1. NC_009138.1.
3D structure databases
ProteinModelPortal	A4G2X2.
ModBase	Search...
Protein-protein interaction databases
STRING	A4G2X2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4932840.
GenomeReviews	Gene locus HEAR0663 in contig CU207211_GR.
KEGG	har:HEAR0663.
NMPDR	fig|204773.3.peg.617.
PATRIC	22111474. VBIHerArs17568_0622.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	LATNRNG.
ProtClustDB	CLSK943215.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4G2X2_HERAR

Accession

Primary (citable) accession number: A4G2X2

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)