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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:HEAR0406
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000100241 – 612DNA mismatch repair protein MutLAdd BLAST612

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR0406

Structurei

3D structure databases

ProteinModelPortaliA4G289
SMRiA4G289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC6 Bacteria
COG0323 LUCA
HOGENOMiHOG000256550
KOiK03572
OMAiQHIAHER
OrthoDBiPOG091H015A

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00149 DNA_mis_repair, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR020667 DNA_mismatch_repair_MutL
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4G289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHASSPSVRP IQALSDQLIS QIAAGEVVER PSAVVKELLE NALDAGATHI
60 70 80 90 100
SVRLEQGGVK RIAITDNGRG IAPEQLPLAL ARHATSKINS LTELENVATL
110 120 130 140 150
GFRGEALASI ASVSQLTLTS RTADAAHAWE ISGVQSIDQK STVAPSSGTA
160 170 180 190 200
GTTVDVLDLY FNTPARRKFL KTEQTEFGHC AEVVRRIALS RPDVAFSLTH
210 220 230 240 250
NGKTIDHWAV NDIARRSAHI LGNEFSAARL PLKETAGPLR LHGFIGLPTA
260 270 280 290 300
SKARGDAQYF YVNGRFVRDK LLMHAVRSAY QDVLHGDRYP SYVISLELDP
310 320 330 340 350
ALVDVNVHPS KIEVRFRDSR AVHQFVFHAV TRALAQTSAT AFGAAPSPTP
360 370 380 390 400
APSSALPWLR EQQQSTFAPQ FNSPYGVAQS AANYGALFAN GPASNDSNSA
410 420 430 440 450
APSLHTAGSH GATTLPDDEF PLGFALAQLH GIFILAQNTK GLVLVDMHAA
460 470 480 490 500
HERILYEQLK HALDDNELQV QPLLIPITFY ADGMEVGTTE DNQDILHALG
510 520 530 540 550
FDIAALSPTT LAVRAVPALL KNADAQTLAR DVLRDVREFG GSRVLLERRN
560 570 580 590 600
ELLGTLACHT AVRANRTLTV PEMNALLRQM EATERADQCN HGRPTWVQLG
610
LSDLDKLFER GR
Length:612
Mass (Da):66,235
Last modified:April 17, 2007 - v1
Checksum:iB3945A1079DA0296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA Translation: CAL60626.1

Genome annotation databases

EnsemblBacteriaiCAL60626; CAL60626; HEAR0406
KEGGihar:HEAR0406

Similar proteinsi

Entry informationi

Entry nameiMUTL_HERAR
AccessioniPrimary (citable) accession number: A4G289
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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