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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciHARS204773:GJCA-392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:HEAR0406
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612DNA mismatch repair protein MutLPRO_1000010024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR0406.

Structurei

3D structure databases

ProteinModelPortaliA4G289.
SMRiA4G289. Positions 9-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC6. Bacteria.
COG0323. LUCA.
HOGENOMiHOG000256550.
KOiK03572.
OMAiQFLFINN.
OrthoDBiEOG6P8TMH.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHASSPSVRP IQALSDQLIS QIAAGEVVER PSAVVKELLE NALDAGATHI
60 70 80 90 100
SVRLEQGGVK RIAITDNGRG IAPEQLPLAL ARHATSKINS LTELENVATL
110 120 130 140 150
GFRGEALASI ASVSQLTLTS RTADAAHAWE ISGVQSIDQK STVAPSSGTA
160 170 180 190 200
GTTVDVLDLY FNTPARRKFL KTEQTEFGHC AEVVRRIALS RPDVAFSLTH
210 220 230 240 250
NGKTIDHWAV NDIARRSAHI LGNEFSAARL PLKETAGPLR LHGFIGLPTA
260 270 280 290 300
SKARGDAQYF YVNGRFVRDK LLMHAVRSAY QDVLHGDRYP SYVISLELDP
310 320 330 340 350
ALVDVNVHPS KIEVRFRDSR AVHQFVFHAV TRALAQTSAT AFGAAPSPTP
360 370 380 390 400
APSSALPWLR EQQQSTFAPQ FNSPYGVAQS AANYGALFAN GPASNDSNSA
410 420 430 440 450
APSLHTAGSH GATTLPDDEF PLGFALAQLH GIFILAQNTK GLVLVDMHAA
460 470 480 490 500
HERILYEQLK HALDDNELQV QPLLIPITFY ADGMEVGTTE DNQDILHALG
510 520 530 540 550
FDIAALSPTT LAVRAVPALL KNADAQTLAR DVLRDVREFG GSRVLLERRN
560 570 580 590 600
ELLGTLACHT AVRANRTLTV PEMNALLRQM EATERADQCN HGRPTWVQLG
610
LSDLDKLFER GR
Length:612
Mass (Da):66,235
Last modified:April 17, 2007 - v1
Checksum:iB3945A1079DA0296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL60626.1.

Genome annotation databases

EnsemblBacteriaiCAL60626; CAL60626; HEAR0406.
KEGGihar:HEAR0406.
PATRICi22110990. VBIHerArs17568_0387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL60626.1.

3D structure databases

ProteinModelPortaliA4G289.
SMRiA4G289. Positions 9-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204773.HEAR0406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL60626; CAL60626; HEAR0406.
KEGGihar:HEAR0406.
PATRICi22110990. VBIHerArs17568_0387.

Phylogenomic databases

eggNOGiENOG4105DC6. Bacteria.
COG0323. LUCA.
HOGENOMiHOG000256550.
KOiK03572.
OMAiQFLFINN.
OrthoDBiEOG6P8TMH.

Enzyme and pathway databases

BioCyciHARS204773:GJCA-392-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiMUTL_HERAR
AccessioniPrimary (citable) accession number: A4G289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 11, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.