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A4G255

- PDXA_HERAR

UniProt

A4G255 - PDXA_HERAR

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, HEAR0368
Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411Substrate By similarity
Binding sitei142 – 1421Substrate By similarity
Metal bindingi175 – 1751Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi220 – 2201Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi275 – 2751Divalent metal cation; shared with dimeric partner By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei292 – 2921Substrate By similarity
Binding sitei301 – 3011Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciHARS204773:GJCA-357-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:HEAR0368
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
ProteomesiUP000006697: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3443444-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_1000051505Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204773.HEAR0368.

Structurei

3D structure databases

ProteinModelPortaliA4G255.
SMRiA4G255. Positions 1-338.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiNLRVFFL.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4G255-1 [UniParc]FASTAAdd to Basket

« Hide

MSKRPTIAIT CGEPAGIGPE ISIRAAWELR ADVKSILIGD AAFLAMIAGA    50
INPDIHLSAL SWQAVRNSGL PAFPRDQITV IDCPLAAHVV PGRLDAQNGR 100
YVLQTLDIAI DGAMQHWFDA IVTAPLQKST INDAGVPFTG HTEYLADKTA 150
TKQVVMMLAT NATLQPLRVA LATTHLALKD VAAAITFDSL AGIIDILHAD 200
LQQKFGIAKP RILVTGLNPH AGEGGYLGRE EIDVITPVLQ AAQAKGYDVR 250
GPYPADTLFQ QKLLAGADCV LAMYHDQGLP VLKYASFGLG VNITLGLPII 300
RTSVDHGTAL DLAAAGLGQA DHGSMLEAIR VAAQMAAASK ASAE 344
Length:344
Mass (Da):36,170
Last modified:April 17, 2007 - v1
Checksum:iAAD3EECB2D566BE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL60592.1.
RefSeqiWP_011869937.1. NC_009138.1.
YP_001098721.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL60592; CAL60592; HEAR0368.
GeneIDi4933139.
KEGGihar:HEAR0368.
PATRICi22110928. VBIHerArs17568_0357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL60592.1 .
RefSeqi WP_011869937.1. NC_009138.1.
YP_001098721.1. NC_009138.1.

3D structure databases

ProteinModelPortali A4G255.
SMRi A4G255. Positions 1-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204773.HEAR0368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL60592 ; CAL60592 ; HEAR0368 .
GeneIDi 4933139.
KEGGi har:HEAR0368.
PATRICi 22110928. VBIHerArs17568_0357.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi NLRVFFL.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci HARS204773:GJCA-357-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiPDXA_HERAR
AccessioniPrimary (citable) accession number: A4G255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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