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A4G1X0

- GCH4_HERAR

UniProt

A4G1X0 - GCH4_HERAR

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei147 – 1471May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciHARS204773:GJCA-272-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:HEAR0280
    OrganismiHerminiimonas arsenicoxydans
    Taxonomic identifieri204773 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
    ProteomesiUP000006697: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261GTP cyclohydrolase FolE2PRO_0000297506Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204773.HEAR0280.

    Structurei

    3D structure databases

    ProteinModelPortaliA4G1X0.
    SMRiA4G1X0. Positions 15-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4G1X0-1 [UniParc]FASTAAdd to Basket

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    MSAIPDVQST PDTRNIVIQR VGVKGVRYPI TVKTSSGVQP SVGSWNMYVR    50
    LTEEQKGTHM SRFIALLEEN NQPLDVAVFG ALMRKMLVLL DADAGRIEVS 100
    FPYFINKTAP VSGVQSLMDY EVGLTGEMKN GELEVTLKVL VPVTSLCPCS 150
    KKISAYGAHN QRSHITVHAV LNGDLVVEEL IAKIEEQASC ELYGLLKRPD 200
    EKYVTERAYD NPKFVEDLVR DVAGMLNKDE RVLAYTLEAE NFESIHNHSA 250
    YALIERDKRL S 261
    Length:261
    Mass (Da):29,114
    Last modified:April 17, 2007 - v1
    Checksum:iFCC2733B8D531C39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL60507.1.
    RefSeqiWP_011869853.1. NC_009138.1.
    YP_001098636.1. NC_009138.1.

    Genome annotation databases

    EnsemblBacteriaiCAL60507; CAL60507; HEAR0280.
    GeneIDi4930877.
    KEGGihar:HEAR0280.
    PATRICi22110760. VBIHerArs17568_0273.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL60507.1 .
    RefSeqi WP_011869853.1. NC_009138.1.
    YP_001098636.1. NC_009138.1.

    3D structure databases

    ProteinModelPortali A4G1X0.
    SMRi A4G1X0. Positions 15-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204773.HEAR0280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL60507 ; CAL60507 ; HEAR0280 .
    GeneIDi 4930877.
    KEGGi har:HEAR0280.
    PATRICi 22110760. VBIHerArs17568_0273.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci HARS204773:GJCA-272-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ULPAs1.

    Entry informationi

    Entry nameiGCH4_HERAR
    AccessioniPrimary (citable) accession number: A4G1X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3