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A4G1X0 (GCH4_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:HEAR0280
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000297506

Sites

Site1471May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A4G1X0 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: FCC2733B8D531C39

FASTA26129,114
        10         20         30         40         50         60 
MSAIPDVQST PDTRNIVIQR VGVKGVRYPI TVKTSSGVQP SVGSWNMYVR LTEEQKGTHM 

        70         80         90        100        110        120 
SRFIALLEEN NQPLDVAVFG ALMRKMLVLL DADAGRIEVS FPYFINKTAP VSGVQSLMDY 

       130        140        150        160        170        180 
EVGLTGEMKN GELEVTLKVL VPVTSLCPCS KKISAYGAHN QRSHITVHAV LNGDLVVEEL 

       190        200        210        220        230        240 
IAKIEEQASC ELYGLLKRPD EKYVTERAYD NPKFVEDLVR DVAGMLNKDE RVLAYTLEAE 

       250        260 
NFESIHNHSA YALIERDKRL S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU207211 Genomic DNA. Translation: CAL60507.1.
RefSeqYP_001098636.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G1X0.
SMRA4G1X0. Positions 15-258.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204773.HEAR0280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL60507; CAL60507; HEAR0280.
GeneID4930877.
KEGGhar:HEAR0280.
PATRIC22110760. VBIHerArs17568_0273.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycHARS204773:GJCA-272-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_HERAR
AccessionPrimary (citable) accession number: A4G1X0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 17, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways