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A4G1X0

- GCH4_HERAR

UniProt

A4G1X0 - GCH4_HERAR

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, HEAR0280
Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei147 – 1471May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciHARS204773:GJCA-272-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:HEAR0280
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
ProteomesiUP000006697: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261GTP cyclohydrolase FolE2UniRule annotation
PRO_0000297506Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR0280.

Structurei

3D structure databases

ProteinModelPortaliA4G1X0.
SMRiA4G1X0. Positions 15-258.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G1X0-1 [UniParc]FASTAAdd to Basket

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MSAIPDVQST PDTRNIVIQR VGVKGVRYPI TVKTSSGVQP SVGSWNMYVR    50
LTEEQKGTHM SRFIALLEEN NQPLDVAVFG ALMRKMLVLL DADAGRIEVS 100
FPYFINKTAP VSGVQSLMDY EVGLTGEMKN GELEVTLKVL VPVTSLCPCS 150
KKISAYGAHN QRSHITVHAV LNGDLVVEEL IAKIEEQASC ELYGLLKRPD 200
EKYVTERAYD NPKFVEDLVR DVAGMLNKDE RVLAYTLEAE NFESIHNHSA 250
YALIERDKRL S 261
Length:261
Mass (Da):29,114
Last modified:April 17, 2007 - v1
Checksum:iFCC2733B8D531C39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL60507.1.
RefSeqiWP_011869853.1. NC_009138.1.
YP_001098636.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL60507; CAL60507; HEAR0280.
GeneIDi4930877.
KEGGihar:HEAR0280.
PATRICi22110760. VBIHerArs17568_0273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU207211 Genomic DNA. Translation: CAL60507.1 .
RefSeqi WP_011869853.1. NC_009138.1.
YP_001098636.1. NC_009138.1.

3D structure databases

ProteinModelPortali A4G1X0.
SMRi A4G1X0. Positions 15-258.
ModBasei Search...

Protein-protein interaction databases

STRINGi 204773.HEAR0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL60507 ; CAL60507 ; HEAR0280 .
GeneIDi 4930877.
KEGGi har:HEAR0280.
PATRICi 22110760. VBIHerArs17568_0273.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci HARS204773:GJCA-272-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiGCH4_HERAR
AccessioniPrimary (citable) accession number: A4G1X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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