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A4G1U6 (PUR9_HERAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:HEAR0255
OrganismHerminiimonas arsenicoxydans [Complete proteome] [HAMAP]
Taxonomic identifier204773 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018893

Sequences

Sequence LengthMass (Da)Tools
A4G1U6 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 3DED62CEC6843A65

FASTA52156,035
        10         20         30         40         50         60 
MIKQALISVS DKTGVLDFAR ALSAMGVNIL STGGTAKLLA ENGISVTEVA DYTGFPEMLD 

        70         80         90        100        110        120 
GRVKTLHPKV HGGILARRDF PEHVAALSKH DIPTIDMVVV NLYPFQQTVA RAECSLEDAI 

       130        140        150        160        170        180 
ENIDIGGPAM LRSSAKNHKD VIVICDPSDY SLVLHELNTN NGEATYETKF ALAKKVFAHT 

       190        200        210        220        230        240 
AQYDGAITNY FTSLGADKQH ATRSSYPATL NLHFEKVQEM RYGENPHQSA AFYRESNPQA 

       250        260        270        280        290        300 
GALANYAQLQ GKELSYNNIA DADAAWECVK TFDEAACVII KHANPCGVAV GITPFEAYSK 

       310        320        330        340        350        360 
ALQTDPTSAF GGIIAFNREV DGNAAEAVAK QFVEVLIAPS FTEQAKKIFA AKQNVRLLEI 

       370        380        390        400        410        420 
PLGDAVNSHD FKRVGGGLLV QSPDAKNVTL AELKVVSKKQ PTPQQLQDLM FAWRVAKFVK 

       430        440        450        460        470        480 
SNAIVFCANG MTMGVGAGQM SRIDSARIAA IKAQNAGLSL VGTAVASDAF FPFRDGLDVV 

       490        500        510        520 
VEAGATSVIH PGGSMRDQEV IDAADEHGIV MLLTGTRHFR H 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU207211 Genomic DNA. Translation: CAL60483.1.
RefSeqYP_001098612.1. NC_009138.1.

3D structure databases

ProteinModelPortalA4G1U6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204773.HEAR0255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL60483; CAL60483; HEAR0255.
GeneID4930797.
KEGGhar:HEAR0255.
PATRIC22110712. VBIHerArs17568_0249.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycHARS204773:GJCA-248-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_HERAR
AccessionPrimary (citable) accession number: A4G1U6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways