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A4G168

- PNCB_HERAR

UniProt

A4G168 - PNCB_HERAR

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciHARS204773:GJCA-15-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:HEAR0018
    OrganismiHerminiimonas arsenicoxydans
    Taxonomic identifieri204773 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
    ProteomesiUP000006697: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Nicotinate phosphoribosyltransferasePRO_1000212085Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204773.HEAR0018.

    Structurei

    3D structure databases

    ProteinModelPortaliA4G168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiKFTMWQA.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4G168-1 [UniParc]FASTAAdd to Basket

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    MPPIVNNLLE NDLYKFTMWQ ALLHSHPEAQ TEYEFVCRNA PAYPLSELKA    50
    DVERELDHLC TLAFRDDELL YLRSLRFMKS DFVDFLTVFR FQRKFITVAA 100
    DGPALRIRAI GPQVHVMGFE IFVLCIVNEL YLRRFDQQAS LTEARRRLQE 150
    KIRLLKNFGK EATRKNPFEF FDFGVRRRFS AAWHEEVVVT LAREVPQYFT 200
    GTSNVHLAKK YGLTPIGTMA HEYLQAYQSF GVRLRDFQKA ALEDWVQEYR 250
    GDLGIALTDV VGMDAFLADF DLYFAKLFDG LRHDSGDPIE WGEKALAHYA 300
    RLRIDAGSKR LVFSDALDLP GAFSLYRHFA DRTLTGFGIG TNLSNDTGIP 350
    ALNIVMKLMA CNGQPVAKLS DSAGKTLCRD ETFLAYLRQV FHHPAVK 397
    Length:397
    Mass (Da):45,514
    Last modified:April 17, 2007 - v1
    Checksum:iB139362578BB4CD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL60255.1.
    RefSeqiWP_011869604.1. NC_009138.1.
    YP_001098384.1. NC_009138.1.

    Genome annotation databases

    EnsemblBacteriaiCAL60255; CAL60255; HEAR0018.
    GeneIDi4933037.
    KEGGihar:HEAR0018.
    PATRICi22110226. VBIHerArs17568_0013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207211 Genomic DNA. Translation: CAL60255.1 .
    RefSeqi WP_011869604.1. NC_009138.1.
    YP_001098384.1. NC_009138.1.

    3D structure databases

    ProteinModelPortali A4G168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204773.HEAR0018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL60255 ; CAL60255 ; HEAR0018 .
    GeneIDi 4933037.
    KEGGi har:HEAR0018.
    PATRICi 22110226. VBIHerArs17568_0013.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi KFTMWQA.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci HARS204773:GJCA-15-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ULPAs1.

    Entry informationi

    Entry nameiPNCB_HERAR
    AccessioniPrimary (citable) accession number: A4G168
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3