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A4G168

- PNCB_HERAR

UniProt

A4G168 - PNCB_HERAR

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Herminiimonas arsenicoxydans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciHARS204773:GJCA-15-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:HEAR0018
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
ProteomesiUP000006697: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Nicotinate phosphoribosyltransferasePRO_1000212085Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR0018.

Structurei

3D structure databases

ProteinModelPortaliA4G168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKFTMWQA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4G168-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPIVNNLLE NDLYKFTMWQ ALLHSHPEAQ TEYEFVCRNA PAYPLSELKA
60 70 80 90 100
DVERELDHLC TLAFRDDELL YLRSLRFMKS DFVDFLTVFR FQRKFITVAA
110 120 130 140 150
DGPALRIRAI GPQVHVMGFE IFVLCIVNEL YLRRFDQQAS LTEARRRLQE
160 170 180 190 200
KIRLLKNFGK EATRKNPFEF FDFGVRRRFS AAWHEEVVVT LAREVPQYFT
210 220 230 240 250
GTSNVHLAKK YGLTPIGTMA HEYLQAYQSF GVRLRDFQKA ALEDWVQEYR
260 270 280 290 300
GDLGIALTDV VGMDAFLADF DLYFAKLFDG LRHDSGDPIE WGEKALAHYA
310 320 330 340 350
RLRIDAGSKR LVFSDALDLP GAFSLYRHFA DRTLTGFGIG TNLSNDTGIP
360 370 380 390
ALNIVMKLMA CNGQPVAKLS DSAGKTLCRD ETFLAYLRQV FHHPAVK
Length:397
Mass (Da):45,514
Last modified:April 17, 2007 - v1
Checksum:iB139362578BB4CD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL60255.1.
RefSeqiWP_011869604.1. NC_009138.1.
YP_001098384.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL60255; CAL60255; HEAR0018.
GeneIDi4933037.
KEGGihar:HEAR0018.
PATRICi22110226. VBIHerArs17568_0013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA. Translation: CAL60255.1 .
RefSeqi WP_011869604.1. NC_009138.1.
YP_001098384.1. NC_009138.1.

3D structure databases

ProteinModelPortali A4G168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204773.HEAR0018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL60255 ; CAL60255 ; HEAR0018 .
GeneIDi 4933037.
KEGGi har:HEAR0018.
PATRICi 22110226. VBIHerArs17568_0013.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi KFTMWQA.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci HARS204773:GJCA-15-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ULPAs1.

Entry informationi

Entry nameiPNCB_HERAR
AccessioniPrimary (citable) accession number: A4G168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 17, 2007
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3