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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:MmarC5_1656
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11311131DNA polymerase II large subunitPRO_1000019389Add
BLAST

Proteomic databases

PRIDEiA4G0G9.

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_1656.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

A4G0G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHVSASKGM TEYFKNILDN VKNLYDLAEG CRKSGYDVTD HVEIPLAKDM
60 70 80 90 100
ADRVEGIVGP KNVAERIREL VSDLGKEPAA LEIAKEIVEG KFGEFGREVG
110 120 130 140 150
AEQAVRTALA VITEGIVAAP LEGIAHVKIK KNNDGGEYLA IYFAGPIRSA
160 170 180 190 200
GGTAQALAVL VGDYVRKNMG LDKFKPTDDE VERYGEEVDL YQSEVTTFQY
210 220 230 240 250
QPKAEEIRVA VRNISVEITG EATDDVEVSG HRDLPRIETN QIRGGALLAL
260 270 280 290 300
VEGVLLKAPK ILRHVDKLGI EGWDWLKELK SKKEELVEEI EEENDEFNYE
310 320 330 340 350
EEEDLSQYED YEVEAVTKFI GEVIAGRPVF SHPSKKGGFR LRYGRSRNTG
360 370 380 390 400
FATDGFHPAI MYLVDDFMAV GTQLKTERPG KATCVVPVDS IEGPIVKLND
410 420 430 440 450
KSVLKIDTVE KAKQYRDDVE EILFLGDILV NYGDFLENNH TILPSSWCTE
460 470 480 490 500
WYEKILKSEN LEYTKEFIEN PDQKEVVKYA KLTNTPLHPK YTYFWHDISK
510 520 530 540 550
DNINVLRNWI IGGRYNESND SWGLTYDPED PEISIVKRYL ELIGCPHTVV
560 570 580 590 600
DEKVEIFEYY PLLYSLGYDF DEKQDVVEDI EEKLQNTKNN MHFINTIAPF
610 620 630 640 650
EIRRNAYIYV GARMGRPEKA ASRKMKPPVN GLFPIGNAGA LVRLINKAVD
660 670 680 690 700
EGKTDEIEIS NVKCSCGNVS LYRTCPFCGS SVEPSGPSRI KLPIKEYWYK
710 720 730 740 750
ALENLKINKA GDVKCIKGMT SKDKIIEPLE KAILRAKNDI FVFKDGTTRF
760 770 780 790 800
DCTDVPVTHF RPVEIHGDIE KLKSLGYLKD IHGNPLENEN QVLELNVQDV
810 820 830 840 850
IVPESCMDYF LNVSKFIDDL LEKYYKKDRF YNVNKREELV GHLIIGMAPH
860 870 880 890 900
TSAGMVGRII GYSKANVGYA HPYFHASKRR NCDGDEDAFF LLLDAFMNFS
910 920 930 940 950
KRFLPDKRGG QMDAPLVLTT ILDPKEVDGE VHNMDSMWEY PLEFYEKSLE
960 970 980 990 1000
GIAPKEIKKI METVEDRLDK ESQYEGIGYT HETLKIDEGP LVCAYKTLGS
1010 1020 1030 1040 1050
MMEKTSAQLA VAKKIRATDE RDVAEKVIQS HFVPDLIGNL RAFSRQGVRC
1060 1070 1080 1090 1100
KCGAKYRRMP LKGICRKCGS RLILTVSKGA VEKYMDVSQT MAEKYNASDY
1110 1120 1130
IKQRLEIIRS GIDSLFVNDK RKQVKIEDFF K
Length:1,131
Mass (Da):128,289
Last modified:April 17, 2007 - v1
Checksum:i7D2826B4CE998567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35953.1.
RefSeqiWP_011869400.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35953; ABO35953; MmarC5_1656.
GeneIDi4928217.
KEGGimmq:MmarC5_1656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35953.1.
RefSeqiWP_011869400.1. NC_009135.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_1656.

Proteomic databases

PRIDEiA4G0G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35953; ABO35953; MmarC5_1656.
GeneIDi4928217.
KEGGimmq:MmarC5_1656.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1691-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiDP2L_METM5
AccessioniPrimary (citable) accession number: A4G0G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: November 11, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.