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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161May be catalytically importantUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:MmarC5_1646
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000686661 – 315GTP cyclohydrolase MptAAdd BLAST315

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_1646.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A4G0F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCNDVQATE PDIKVSLTRV GVTNLKKLVK LKRKNKRDIV LLPTFEVFVD
60 70 80 90 100
LPSSQKGIHM SRSPEVIEEV VENILLEKEI YGVEDLSVEI VMKLFEKHEY
110 120 130 140 150
ATRAEIMLYS DYMMEEKSPV TQKDSQEIGK IIARAYGVKD ENGKIAVKKM
160 170 180 190 200
VGAEVVGITA CPCAQNMLKE NAVANLKEKG FSSEEIEKIL DSVTIATHNQ
210 220 230 240 250
RGIGTVMIEV PNGYAVGISK IIKIIKNSMS GEVYELLKRS DEAFVVEAAH
260 270 280 290 300
KNPKFVEDCA REMIKRVVDV FDYLPEDTQV LVRQVNKESI HRHDAFAERN
310
STIRELRDEL KTLTN
Length:315
Mass (Da):35,628
Last modified:April 17, 2007 - v1
Checksum:iAF0ED04737E9FC2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35943.1.
RefSeqiWP_011869390.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35943; ABO35943; MmarC5_1646.
GeneIDi4928995.
KEGGimmq:MmarC5_1646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35943.1.
RefSeqiWP_011869390.1. NC_009135.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_1646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35943; ABO35943; MmarC5_1646.
GeneIDi4928995.
KEGGimmq:MmarC5_1646.

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Enzyme and pathway databases

UniPathwayiUPA00065.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPTA_METM5
AccessioniPrimary (citable) accession number: A4G0F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.