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A4G0F2

- TF2B_METM5

UniProt

A4G0F2 - TF2B_METM5

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Protein

Transcription initiation factor IIB

Gene
tfb, MmarC5_1639
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi43 – 431Zinc By similarity
Metal bindingi46 – 461Zinc By similarity
Metal bindingi62 – 621Zinc By similarity
Metal bindingi65 – 651Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1670-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Short name:
TFIIB
Gene namesi
Name:tfb
Ordered Locus Names:MmarC5_1639
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Transcription initiation factor IIBUniRule annotationPRO_1000080108Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1639.

Structurei

3D structure databases

ProteinModelPortaliA4G0F2.
SMRiA4G0F2. Positions 143-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati156 – 239841UniRule annotationAdd
BLAST
Repeati250 – 331822UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 1 hit.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G0F2-1 [UniParc]FASTAAdd to Basket

« Hide

MKVESVVKEE TKKPERKIKL AIAKPEDYSN KNVILEKEEE LICPVCGSKS    50
IIKDYERAEI VCEMCGCVLQ QNLFDVGPEW RAFDHEQRVK RSRVGAPMTY 100
TIHDKGLSTV IDWRNKDSYG KDISADKRAQ LYRLRKWQRR IRVSDASERN 150
LAFALSELDR IASKLGLPRN VRENAAVLYR GAVEKGLIRG RSIEGVAAAA 200
LYAACRRCKV PRTLDEIAEV SRVDRKEIGR TYRFISRELN IRLAPTNPVD 250
YVPRFASELK LPGEVESKAI SILQKAGEKG LTSSRGPTGV AAAAIYIASV 300
LQGTRRTQRE VADVAGVTEV TIRNRYKELT EHLDIDVTL 339
Length:339
Mass (Da):38,230
Last modified:April 17, 2007 - v1
Checksum:i9E077B3A604C49CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35936.1.
RefSeqiWP_011869383.1. NC_009135.1.
YP_001098150.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35936; ABO35936; MmarC5_1639.
GeneIDi4928835.
KEGGimmq:MmarC5_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35936.1 .
RefSeqi WP_011869383.1. NC_009135.1.
YP_001098150.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4G0F2.
SMRi A4G0F2. Positions 143-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_1639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35936 ; ABO35936 ; MmarC5_1639 .
GeneIDi 4928835.
KEGGi mmq:MmarC5_1639.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MMAR402880:GJ2R-1670-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 1 hit.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiTF2B_METM5
AccessioniPrimary (citable) accession number: A4G0F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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