SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4G043

- HPRT_METM5

UniProt

A4G043 - HPRT_METM5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, MmarC5_1530
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1551-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:MmarC5_1530
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000329374Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_1530.

Structurei

3D structure databases

ProteinModelPortaliA4G043.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4G043-1 [UniParc]FASTAAdd to Basket

« Hide

MSRLLEESLK TCPIVKRGEY HYFIHPISDG VPLVEPELLR DISTRVIKMI    50
DTEVDKIVTA EAMGIPIVTA VSIATDIPYV IMRKREYLLE GEIPVHQETG 100
YSKGELYLNG INKGDKVVIL DDVISTGGTL VAIINALKRA GADIRDVLCI 150
IDRGNGQNIV EEKTGYKVKT LVKIEVVDGK VQILK 185
Length:185
Mass (Da):20,485
Last modified:April 17, 2007 - v1
Checksum:iD878584DA4947FE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35827.1.
RefSeqiWP_011869274.1. NC_009135.1.
YP_001098041.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35827; ABO35827; MmarC5_1530.
GeneIDi4928894.
KEGGimmq:MmarC5_1530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35827.1 .
RefSeqi WP_011869274.1. NC_009135.1.
YP_001098041.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4G043.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_1530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35827 ; ABO35827 ; MmarC5_1530 .
GeneIDi 4928894.
KEGGi mmq:MmarC5_1530.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000228520.
KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MMAR402880:GJ2R-1551-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiHPRT_METM5
AccessioniPrimary (citable) accession number: A4G043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi