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Protein

tRNA (guanine(26)-N(2))-dimethyltransferase

Gene

trm1

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.UniRule annotation

Catalytic activityi

2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine(26) in tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-1499-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(26)-N(2))-dimethyltransferaseUniRule annotation (EC:2.1.1.216UniRule annotation)
Alternative name(s):
tRNA 2,2-dimethylguanosine-26 methyltransferaseUniRule annotation
tRNA(guanine-26,N(2)-N(2)) methyltransferaseUniRule annotation
tRNA(m(2,2)G26)dimethyltransferaseUniRule annotation
Gene namesi
Name:trm1UniRule annotation
Ordered Locus Names:MmarC5_1472
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001149771 – 373tRNA (guanine(26)-N(2))-dimethyltransferaseAdd BLAST373

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1472

Structurei

3D structure databases

ProteinModelPortaliA4FZY5
SMRiA4FZY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 365Trm1 methyltransferaseUniRule annotationAdd BLAST364

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01219 Archaea
COG1867 LUCA
HOGENOMiHOG000229931
KOiK00555
OMAiVFYNPVM
OrthoDBiPOG093Z0BNY

Family and domain databases

HAMAPiMF_00290 tRNA_dimethyltr_TRM1, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002905 Trm1
IPR022923 TRM1_arc_bac
PANTHERiPTHR10631 PTHR10631, 1 hit
PfamiView protein in Pfam
PF02005 TRM, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00308 TRM1, 1 hit
PROSITEiView protein in PROSITE
PS51626 SAM_MT_TRM1, 1 hit

Sequencei

Sequence statusi: Complete.

A4FZY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIISEGETK LMVPEESTLS KKDTVFYNPV METNRNISVS VVQSFLDNFK
60 70 80 90 100
RDEFLMCDPL GGSGARGIRY ANELEFNGDL KVSIGDINPS AVKMIKENLK
110 120 130 140 150
LNELENVEVF HEDANVLLSK NFKVFNVVDL DPFGSPVPYL DSGIRASLTK
160 170 180 190 200
GGLLCMTATD TAVLCGAYRK TCIRKYNAIP LKGDKELAVR LMIGYAVKMA
210 220 230 240 250
SKYDIGLKPI FSHVTDHYAR TFMVTERGAG KADSAIENLG YIRQDSEQKS
260 270 280 290 300
FKAFEEGYEK GYAGSFYLGE ISDKDIVQNS LETAKNRNYS KRAVDILELI
310 320 330 340 350
SKESEIEQVG CFDIHELCSF IKKLVPPVND IMDNLKENGF KVSRVHYNPY
360 370
GLKTDAELSD LVVLISEYHS KKY
Length:373
Mass (Da):41,842
Last modified:April 17, 2007 - v1
Checksum:i3C11E36A0B1D6D1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO35769.1
RefSeqiWP_011869219.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO35769; ABO35769; MmarC5_1472
GeneIDi4927645
KEGGimmq:MmarC5_1472

Similar proteinsi

Entry informationi

Entry nameiTRM1_METM5
AccessioniPrimary (citable) accession number: A4FZY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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