A4FZX3 (A4FZX3_METM5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

MmarC5_1460

Organism

Methanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]

Taxonomic identifier

402880 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405
Ligand	Magnesium HAMAP MF_01405 Manganese HAMAP MF_01405 Metal-binding HAMAP MF_01405 Nucleotide-binding HAMAP MF_01405
Molecular function	Hydrolase HAMAP MF_01405 RuleBase RU003781 EMBL ABO35757.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	7 – 12	6	Substrate binding By similarity HAMAP MF_01405
	Region	64 – 65	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	36	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	64	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	143	1	Substrate By similarity HAMAP MF_01405
	Binding site	163	1	Substrate By similarity HAMAP MF_01405
	Binding site	169	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	A4FZX3 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 9A59802D26A93F51	FASTA	184	20,997
	10 20 30 40 50 60 MKIYFATGNQ NKVDEAKIIL KDVDCEIEQI EVPYAEVQGR IEEVSAFGVL EVFEKFNRPV 70 80 90 100 110 120 IVEDSGFFIE KLNDFPGTYS KFVQESLGNE GILKLLENES NRNAYFKTVI GYYDGDNIKL 130 140 150 160 170 180 FTGIVKGTVS NEIKDGGFGF AYDSIFIPEG ETKTFAEMTT EEKSEISHRK RAFYELKNYL ETNL

References

[1]

"Complete sequence of chromosome of Methanococcus maripaludis C5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000609 Genomic DNA. Translation: ABO35757.1.
RefSeq	YP_001097971.1. NC_009135.1.
3D structure databases
ProteinModelPortal	A4FZX3.
SMR	A4FZX3. Positions 2-180.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FZX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4927541.
GenomeReviews	Gene locus MmarC5_1460 in contig CP000609_GR.
KEGG	mmq:MmarC5_1460.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10472.
HOGENOM	HBG697237.
OMA	VEDSGFF.
PhylomeDB	A4FZX3.
ProtClustDB	PRK14821.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4FZX3_METM5

Accession

Primary (citable) accession number: A4FZX3

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)