A4FZP2 (KHSE_METM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	MmarC5_1378

Organism

Methanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]

Taxonomic identifier

402880 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Homoserine kinase HAMAP MF_00384		PRO_1000049143
Regions
	Nucleotide binding	89 – 99	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A4FZP2 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 00F08906FD944819	FASTA	301	32,498
	10 20 30 40 50 60 MKKVKVCSPG TSANLGPGYD IFGLALSKPY DILEVEKTEK GIIISVEGEK AEEIPTNVDE 70 80 90 100 110 120 NTAGVVAKKM MEDFNIQSGI HIHINKGIKP GSGLGSSSAS CAGVAFALNE LFELKLSKLE 130 140 150 160 170 180 LVKYSSLGEA VAAGAPHADN VAPAIFGGFT LTTSYDPLEV LHIPVDIEVL VALPNIQVST 190 200 210 220 230 240 KTAREILPKE IPIKYMVNNV GKAAGMVYAL YNNDLELFGR YMSKDCVVEP CRANLIDGYA 250 260 270 280 290 300 EVKEKVKDLV YGITISGSGP AIITIPKKEH VIDIENIFKE VWNCPVYYTK VGPGCYVEEI E

References

[1]

"Complete sequence of chromosome of Methanococcus maripaludis C5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000609 Genomic DNA. Translation: ABO35676.1.
RefSeq	YP_001097890.1. NC_009135.1.
3D structure databases
ProteinModelPortal	A4FZP2.
SMR	A4FZP2. Positions 1-297.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FZP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4928205.
GenomeReviews	Gene locus MmarC5_1378 in contig CP000609_GR.
KEGG	mmq:MmarC5_1378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05905.
HOGENOM	HBG646290.
OMA	GSAHADN.
PhylomeDB	A4FZP2.
ProtClustDB	PRK01212.
Enzyme and pathway databases
BioCyc	MMAR402880:MMARC5_1378-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_METM5

Accession

Primary (citable) accession number: A4FZP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program