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Protein

Shikimate kinase

Gene

aroK

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 9611ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1374-MONOMER.
UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:MmarC5_1354
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Shikimate kinasePRO_1000059934Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1354.

Structurei

3D structure databases

ProteinModelPortaliA4FZL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01025. Archaea.
COG1685. LUCA.
HOGENOMiHOG000105526.
KOiK00891.
OMAiDATASYY.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00370. Shik_kinase_arch. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR010189. SK_arc.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005758. Shikimt_kin_arch. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01920. Shik_kin_archae. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FZL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCSAVSLGS GTIINAIATG FGSAFGVDLK IKADVELVDN CKKIINGISI
60 70 80 90 100
DNPTLKPSLV ERCVKNVLDH FEVDYSAKIS TSGDIPIKSG LSSSSAASNA
110 120 130 140 150
AVLATIGALG EKVDSDLVLD LAIKSSFEEK LTITGAYDDA TASYFGGITV
160 170 180 190 200
CNNMERKILK KDEFKEDIKV IVLMPEFQKN VDVNRMKLIK DYVEIAFEKC
210 220 230 240 250
MEGDYYKALF LNGLLYSSAL NFPSNISVDA LEAGAITAGL SGTGPSYVAL
260 270 280
CYSEDKKNVE NALKKYGNTV ITKPSTNGAR ILY
Length:283
Mass (Da):30,363
Last modified:April 17, 2007 - v1
Checksum:iD9E2C4B0322AFCB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35652.1.
RefSeqiWP_011869103.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35652; ABO35652; MmarC5_1354.
GeneIDi4928198.
KEGGimmq:MmarC5_1354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35652.1.
RefSeqiWP_011869103.1. NC_009135.1.

3D structure databases

ProteinModelPortaliA4FZL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_1354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35652; ABO35652; MmarC5_1354.
GeneIDi4928198.
KEGGimmq:MmarC5_1354.

Phylogenomic databases

eggNOGiarCOG01025. Archaea.
COG1685. LUCA.
HOGENOMiHOG000105526.
KOiK00891.
OMAiDATASYY.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.
BioCyciMMAR402880:GJ2R-1374-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00370. Shik_kinase_arch. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR010189. SK_arc.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005758. Shikimt_kin_arch. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01920. Shik_kin_archae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAROK_METM5
AccessioniPrimary (citable) accession number: A4FZL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.