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A4FZL0

- AMPPA_METM5

UniProt

A4FZL0 - AMPPA_METM5

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Protein
AMP phosphorylase
Gene
MmarC5_1346
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701AMP; via amide nitrogen By similarity
Binding sitei205 – 2051AMP; via amide nitrogen By similarity
Active sitei258 – 2581Proton donor By similarity
Binding sitei266 – 2661AMP By similarity
Binding sitei290 – 2901AMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2016AMP By similarity

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase (EC:2.4.2.57)
Short name:
AMPpase
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name:
NMP phosphorylase
Gene namesi
Ordered Locus Names:MmarC5_1346
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505AMP phosphorylaseUniRule annotation
PRO_0000314723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1346.

Structurei

3D structure databases

ProteinModelPortaliA4FZL0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiHYRITED.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FZL0-1 [UniParc]FASTAAdd to Basket

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MLFLNAKFID LDLGENAVIV NEEDLKGTSY YPQDRVLIES HAGSVIGNIY    50
STKTMVNKGE VGMLVSELAE ISISEGEEVK LRHAEKPESI PFIKKKMDGQ 100
VLNPHEIRTI IDEIVSKKLS NIELSAFVSS TYINGMNMDE ISEMTKRIAE 150
TGDMIAWEKS LVVDIHSIGG VPGNKYALLS IPILAAAGIT VPKTSSRAIT 200
SPAGTADVME VLTNVELKEE EIKRIVKTTN GCLAWGGGVN LAPADDIIIN 250
VERPVSIDPQ PQLLASVMAK KIATGIKYTV IDIPVGKGVK IKNEAEGAKL 300
ARKFIELGES LNIKVECVLT YGGQPLGRAI GPALEAREAI EALQDPKNAP 350
KSLIEKALSL AGILLELGGA AQIGEGQNLA WEILESGKAL EKFNQIITEQ 400
GGTPKKPEEI ELGDYVEEIL APIDGYITDI SNTAITNVVK EAGAPRDKKA 450
GILLNSKIGN KVKQGDVLYT IYSGSEERLV SAINLARRVY PVKVEGMLIE 500
RISKF 505
Length:505
Mass (Da):54,533
Last modified:April 17, 2007 - v1
Checksum:iAFA5E60A91E6691E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35644.1.
RefSeqiYP_001097858.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35644; ABO35644; MmarC5_1346.
GeneIDi4927907.
KEGGimmq:MmarC5_1346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35644.1 .
RefSeqi YP_001097858.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FZL0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_1346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35644 ; ABO35644 ; MmarC5_1346 .
GeneIDi 4927907.
KEGGi mmq:MmarC5_1346.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi HYRITED.

Enzyme and pathway databases

BioCyci MMAR402880:GJ2R-1366-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiAMPPA_METM5
AccessioniPrimary (citable) accession number: A4FZL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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