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Reviewed, UniProtKB/Swiss-Prot A4FZG7 (MTD_METM5)

Last modified November 25, 2008. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    F420-dependent methylenetetrahydromethanopterin dehydrogenase
      Short name=MTD
    EC=1.5.99.9
Alternative name(s):
    Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase
Gene names
Name: mtd
Ordered Locus Names: MmarC5_1303
OrganismMethanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]
Taxonomic identifier402880 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT By similarity.

Catalytic activity

5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420.

Pathway

One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methylene-H(4)MPT from 5,10-methenyl-H(4)MPT (cofactor F420 route): step 1/1.

Sequence similarities

Belongs to the MTD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277F420-dependent methylenetetrahydromethanopterin dehydrogenase
PRO_1000007671

Sequences

Sequence LengthMass (Da)Tools
A4FZG7-1 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: EDF71E437BD1A2F8

FASTA27729,936
        10         20         30         40         50         60 
MVVKIGILKC GNIGMSPVVD LCLDERADRN DIDVRVLGSG AKMNPDQVEE VAKKMVEEVK 

        70         80         90        100        110        120 
PDFIVYIGPN PAAPGPKKAR EILSAGGIPA VIIGDAPGIK DKDAMAEEGL GYVLIKCDPM 

       130        140        150        160        170        180 
IGARRQFLDP VEMAMFNADV IRVLAGTGAL RVVQNAIDDM VFAVEEGKEI PLPKIVITEQ 

       190        200        210        220        230        240 
KAVEAMDFAN PYAKAKAMAA FVMAEKVADI DVKGCFMTKE MEKYIPIVAS AHETIRYAAK 

       250        260        270 
LVDEARELEK ATDAVSRKPH AGAGQILNKC KLMEKPE 

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References

[1]"Complete sequence of chromosome of Methanococcus maripaludis C5."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000609 Genomic DNA. Translation: ABO35601.1.
RefSeqYP_001097815.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4929158.
GenomeReviewsGene locus MmarC5_1303 in contig CP000609_GR.
KEGGmmq:MmarC5_1303.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_00058.
[Tree]
InterProIPR002844. Methylene_DHase.
[Graphical view]
PfamPF01993. MTD. 1 hit.
[Graphical view]
PIRSFPIRSF005627. MTD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTD_METM5
AccessionPrimary (citable) accession number: A4FZG7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: November 25, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents