Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1081-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:MmarC5_1067Imported
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)Imported
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1067.

Structurei

3D structure databases

ProteinModelPortaliA4FYT6.
SMRiA4FYT6. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0152.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FYT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYDISKITA KEPIYAGKAK SIYKIEENEK EVLVEFRDDI TAGNGAKHDV
60 70 80 90 100
KSGKGYLNTL ISNELFKILE QNNVPTHLIE YIEPNHMIAK NVKIIPLEVI
110 120 130 140 150
VRNIAAGSLC KKYPFEQGQV LKTAVTQFDY KNDDYGDPML NNEITIELGL
160 170 180 190 200
ATEEELVEIK KLALKVNDVL KGFFDEKGII LVDFKIEVGK TVDGDIVVAD
210 220 230 240
EISPDTMRLW DKETKDVLDK DVFRKDLGDV LEKYKTVAKR IGCLK
Length:245
Mass (Da):27,699
Last modified:April 17, 2007 - v1
Checksum:i681A75F17A923704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35370.1.
RefSeqiWP_011868823.1. NC_009135.1.
YP_001097585.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35370; ABO35370; MmarC5_1067.
GeneIDi4927538.
KEGGimmq:MmarC5_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35370.1.
RefSeqiWP_011868823.1. NC_009135.1.
YP_001097585.1. NC_009135.1.

3D structure databases

ProteinModelPortaliA4FYT6.
SMRiA4FYT6. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_1067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35370; ABO35370; MmarC5_1067.
GeneIDi4927538.
KEGGimmq:MmarC5_1067.

Phylogenomic databases

eggNOGiCOG0152.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BioCyciMMAR402880:GJ2R-1081-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333Imported.

Entry informationi

Entry nameiA4FYT6_METM5
AccessioniPrimary (citable) accession number: A4FYT6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.