A4FYT6 (A4FYT6_METM5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP-Rule MF_00137
EC=6.3.2.6 HAMAP-Rule MF_00137

Alternative name(s):
SAICAR synthetase HAMAP-Rule MF_00137

Gene names

Name:	purC HAMAP-Rule MF_00137
Ordered Locus Names:	MmarC5_1067 EMBL ABO35370.1

Organism

Methanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP] EMBL ABO35370.1

Taxonomic identifier

402880 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP-Rule MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP-Rule MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP-Rule MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP-Rule MF_00137
Ligand	ATP-binding HAMAP-Rule MF_00137 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_00137 EMBL ABO35370.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4FYT6 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 681A75F17A923704	FASTA	245	27,699
	10 20 30 40 50 60 MSYDISKITA KEPIYAGKAK SIYKIEENEK EVLVEFRDDI TAGNGAKHDV KSGKGYLNTL 70 80 90 100 110 120 ISNELFKILE QNNVPTHLIE YIEPNHMIAK NVKIIPLEVI VRNIAAGSLC KKYPFEQGQV 130 140 150 160 170 180 LKTAVTQFDY KNDDYGDPML NNEITIELGL ATEEELVEIK KLALKVNDVL KGFFDEKGII 190 200 210 220 230 240 LVDFKIEVGK TVDGDIVVAD EISPDTMRLW DKETKDVLDK DVFRKDLGDV LEKYKTVAKR IGCLK

References

[1]

"Complete sequence of chromosome of Methanococcus maripaludis C5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000609 Genomic DNA. Translation: ABO35370.1.
RefSeq	YP_001097585.1. NC_009135.1.
3D structure databases
ProteinModelPortal	A4FYT6.
SMR	A4FYT6. Positions 1-244.
ModBase	Search...
Protein-protein interaction databases
STRING	402880.MmarC5_1067.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO35370; ABO35370; MmarC5_1067.
GeneID	4927538.
KEGG	mmq:MmarC5_1067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HOG000082629.
KO	K01923.
OMA	VQYFKDD.
ProtClustDB	PRK09362.
Enzyme and pathway databases
BioCyc	MMAR402880:GJ2R-1081-MONOMER.
UniPathway	UPA00074; UER00131.
Family and domain databases
Gene3D	3.30.470.20. 1 hit.
HAMAP	MF_00137. SAICAR_synth.
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
PANTHER	PTHR11609. PTHR11609. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4FYT6_METM5

Accession

Primary (citable) accession number: A4FYT6

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)