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A4FYS5 (OTC_METM5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase

Short name=OTCase
EC=2.1.3.3
Gene names
Name:argF
Ordered Locus Names:MmarC5_1054
OrganismMethanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]
Taxonomic identifier402880 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity. HAMAP-Rule MF_01109

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP-Rule MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP-Rule MF_01109

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Ornithine carbamoyltransferase HAMAP-Rule MF_01109
PRO_1000084849

Regions

Region47 – 515Carbamoyl phosphate binding By similarity
Region125 – 1284Carbamoyl phosphate binding By similarity
Region225 – 2262Ornithine binding By similarity
Region261 – 2644Carbamoyl phosphate binding By similarity

Sites

Binding site41Carbamoyl phosphate By similarity
Binding site981Carbamoyl phosphate By similarity
Binding site1561Ornithine By similarity
Binding site2211Ornithine By similarity
Binding site2721Carbamoyl phosphate By similarity
Binding site2901Carbamoyl phosphate By similarity
Site251Important for structural integrity By similarity
Site1381Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
A4FYS5 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 46E99447238C961D

FASTA30433,996
        10         20         30         40         50         60 
MDLLTLWNLE REEVLKIIED AEYFKKNRCG HDILKNKSIA LIFESPSTRT RMSFDLAVHE 

        70         80         90        100        110        120 
LGGHSLMMNE GEIHLGKKES IADTARVMSR FVDAIVARVK SHKTLEDLAE YGSVPVINAL 

       130        140        150        160        170        180 
CDLAHPCQIL ADLLTMKENG KDFKGLKLAY FGDGNNVSNS LMIAGAILGM DVVIATPRSY 

       190        200        210        220        230        240 
EPSGLFVKKA LEIIAKYGEG SLTLTDDPEI AAKDADVLYT DVWISMNDKN KNLEEILKIF 

       250        260        270        280        290        300 
PKFQINAELL SKAKEDAIVL HCLPANRGFE ITDEVIDGKQ SKVFDQAENR LHAQKSVLKY 


IFEH 

« Hide

References

[1]"Complete sequence of chromosome of Methanococcus maripaludis C5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000609 Genomic DNA. Translation: ABO35359.1.
RefSeqYP_001097574.1. NC_009135.1.

3D structure databases

ProteinModelPortalA4FYS5.
SMRA4FYS5. Positions 2-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402880.MmarC5_1054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO35359; ABO35359; MmarC5_1054.
GeneID4927736.
KEGGmmq:MmarC5_1054.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0078.
HOGENOMHOG000022686.
KOK00611.
OMALAHADSE.

Enzyme and pathway databases

BioCycMMAR402880:GJ2R-1068-MONOMER.
UniPathwayUPA00068; UER00112.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_01109. OTCase.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOTC_METM5
AccessionPrimary (citable) accession number: A4FYS5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways