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A4FYS5

- OTC_METM5

UniProt

A4FYS5 - OTC_METM5

Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei4 – 41Carbamoyl phosphateUniRule annotation
    Sitei25 – 251Important for structural integrityUniRule annotation
    Binding sitei98 – 981Carbamoyl phosphateUniRule annotation
    Sitei138 – 1381Important for structural integrityUniRule annotation
    Binding sitei156 – 1561OrnithineBy similarity
    Binding sitei221 – 2211OrnithineBy similarity
    Binding sitei272 – 2721Carbamoyl phosphateUniRule annotation
    Binding sitei290 – 2901Carbamoyl phosphateUniRule annotation

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciMMAR402880:GJ2R-1068-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
    Short name:
    OTCaseUniRule annotation
    Gene namesi
    Name:argFUniRule annotation
    Ordered Locus Names:MmarC5_1054
    OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
    Taxonomic identifieri402880 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000253: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Ornithine carbamoyltransferasePRO_1000084849Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402880.MmarC5_1054.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FYS5.
    SMRiA4FYS5. Positions 2-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni47 – 515Carbamoyl phosphate bindingUniRule annotation
    Regioni125 – 1284Carbamoyl phosphate bindingUniRule annotation
    Regioni225 – 2262Ornithine bindingUniRule annotation
    Regioni261 – 2644Carbamoyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0078.
    HOGENOMiHOG000022686.
    KOiK00611.
    OMAiLAHADSE.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4FYS5-1 [UniParc]FASTAAdd to Basket

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    MDLLTLWNLE REEVLKIIED AEYFKKNRCG HDILKNKSIA LIFESPSTRT    50
    RMSFDLAVHE LGGHSLMMNE GEIHLGKKES IADTARVMSR FVDAIVARVK 100
    SHKTLEDLAE YGSVPVINAL CDLAHPCQIL ADLLTMKENG KDFKGLKLAY 150
    FGDGNNVSNS LMIAGAILGM DVVIATPRSY EPSGLFVKKA LEIIAKYGEG 200
    SLTLTDDPEI AAKDADVLYT DVWISMNDKN KNLEEILKIF PKFQINAELL 250
    SKAKEDAIVL HCLPANRGFE ITDEVIDGKQ SKVFDQAENR LHAQKSVLKY 300
    IFEH 304
    Length:304
    Mass (Da):33,996
    Last modified:April 17, 2007 - v1
    Checksum:i46E99447238C961D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35359.1.
    RefSeqiWP_011868812.1. NC_009135.1.
    YP_001097574.1. NC_009135.1.

    Genome annotation databases

    EnsemblBacteriaiABO35359; ABO35359; MmarC5_1054.
    GeneIDi4927736.
    KEGGimmq:MmarC5_1054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35359.1 .
    RefSeqi WP_011868812.1. NC_009135.1.
    YP_001097574.1. NC_009135.1.

    3D structure databases

    ProteinModelPortali A4FYS5.
    SMRi A4FYS5. Positions 2-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402880.MmarC5_1054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO35359 ; ABO35359 ; MmarC5_1054 .
    GeneIDi 4927736.
    KEGGi mmq:MmarC5_1054.

    Phylogenomic databases

    eggNOGi COG0078.
    HOGENOMi HOG000022686.
    KOi K00611.
    OMAi LAHADSE.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci MMAR402880:GJ2R-1068-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C5 / ATCC BAA-1333.

    Entry informationi

    Entry nameiOTC_METM5
    AccessioniPrimary (citable) accession number: A4FYS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3