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A4FYS5

- OTC_METM5

UniProt

A4FYS5 - OTC_METM5

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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41Carbamoyl phosphateUniRule annotation
Sitei25 – 251Important for structural integrityUniRule annotation
Binding sitei98 – 981Carbamoyl phosphateUniRule annotation
Sitei138 – 1381Important for structural integrityUniRule annotation
Binding sitei156 – 1561OrnithineBy similarity
Binding sitei221 – 2211OrnithineBy similarity
Binding sitei272 – 2721Carbamoyl phosphateUniRule annotation
Binding sitei290 – 2901Carbamoyl phosphateUniRule annotation

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-1068-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotation
Ordered Locus Names:MmarC5_1054
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Ornithine carbamoyltransferasePRO_1000084849Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1054.

Structurei

3D structure databases

ProteinModelPortaliA4FYS5.
SMRiA4FYS5. Positions 2-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni47 – 515Carbamoyl phosphate bindingUniRule annotation
Regioni125 – 1284Carbamoyl phosphate bindingUniRule annotation
Regioni225 – 2262Ornithine bindingUniRule annotation
Regioni261 – 2644Carbamoyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiLAHADSE.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FYS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLLTLWNLE REEVLKIIED AEYFKKNRCG HDILKNKSIA LIFESPSTRT
60 70 80 90 100
RMSFDLAVHE LGGHSLMMNE GEIHLGKKES IADTARVMSR FVDAIVARVK
110 120 130 140 150
SHKTLEDLAE YGSVPVINAL CDLAHPCQIL ADLLTMKENG KDFKGLKLAY
160 170 180 190 200
FGDGNNVSNS LMIAGAILGM DVVIATPRSY EPSGLFVKKA LEIIAKYGEG
210 220 230 240 250
SLTLTDDPEI AAKDADVLYT DVWISMNDKN KNLEEILKIF PKFQINAELL
260 270 280 290 300
SKAKEDAIVL HCLPANRGFE ITDEVIDGKQ SKVFDQAENR LHAQKSVLKY

IFEH
Length:304
Mass (Da):33,996
Last modified:April 17, 2007 - v1
Checksum:i46E99447238C961D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35359.1.
RefSeqiWP_011868812.1. NC_009135.1.
YP_001097574.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35359; ABO35359; MmarC5_1054.
GeneIDi4927736.
KEGGimmq:MmarC5_1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35359.1 .
RefSeqi WP_011868812.1. NC_009135.1.
YP_001097574.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FYS5.
SMRi A4FYS5. Positions 2-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_1054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35359 ; ABO35359 ; MmarC5_1054 .
GeneIDi 4927736.
KEGGi mmq:MmarC5_1054.

Phylogenomic databases

eggNOGi COG0078.
HOGENOMi HOG000022686.
KOi K00611.
OMAi LAHADSE.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci MMAR402880:GJ2R-1068-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiOTC_METM5
AccessioniPrimary (citable) accession number: A4FYS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3