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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Carbamoyl phosphateUniRule annotation1
Binding sitei156OrnithineUniRule annotation1
Binding sitei221OrnithineUniRule annotation1
Binding sitei290Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-1070-MONOMER
UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotation
Ordered Locus Names:MmarC5_1054
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000848491 – 304Ornithine carbamoyltransferaseAdd BLAST304

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_1054

Structurei

3D structure databases

ProteinModelPortaliA4FYS5
SMRiA4FYS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 50Carbamoyl phosphate bindingUniRule annotation4
Regioni125 – 128Carbamoyl phosphate bindingUniRule annotation4
Regioni225 – 226Ornithine bindingUniRule annotation2
Regioni262 – 263Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00912 Archaea
COG0078 LUCA
HOGENOMiHOG000022686
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG093Z05BF

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit

Sequencei

Sequence statusi: Complete.

A4FYS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLTLWNLE REEVLKIIED AEYFKKNRCG HDILKNKSIA LIFESPSTRT
60 70 80 90 100
RMSFDLAVHE LGGHSLMMNE GEIHLGKKES IADTARVMSR FVDAIVARVK
110 120 130 140 150
SHKTLEDLAE YGSVPVINAL CDLAHPCQIL ADLLTMKENG KDFKGLKLAY
160 170 180 190 200
FGDGNNVSNS LMIAGAILGM DVVIATPRSY EPSGLFVKKA LEIIAKYGEG
210 220 230 240 250
SLTLTDDPEI AAKDADVLYT DVWISMNDKN KNLEEILKIF PKFQINAELL
260 270 280 290 300
SKAKEDAIVL HCLPANRGFE ITDEVIDGKQ SKVFDQAENR LHAQKSVLKY

IFEH
Length:304
Mass (Da):33,996
Last modified:April 17, 2007 - v1
Checksum:i46E99447238C961D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO35359.1
RefSeqiWP_011868812.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO35359; ABO35359; MmarC5_1054
GeneIDi4927736
KEGGimmq:MmarC5_1054

Similar proteinsi

Entry informationi

Entry nameiOTC_METM5
AccessioniPrimary (citable) accession number: A4FYS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health