A4FYD7 (APT1_METM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase 1
Short name=APRT 1
EC=2.4.2.7

Gene names

Name:	apt1
Ordered Locus Names:	MmarC5_0915

Organism

Methanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]

Taxonomic identifier

402880 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Adenine phosphoribosyltransferase 1 HAMAP MF_00004		PRO_0000329373

Sequences

	Sequence		Length	Mass (Da)
	A4FYD7 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: DEE85711426736B0	FASTA	172	18,967
	10 20 30 40 50 60 MDLRKKIRIV EDFPIEGISF KDVTPILKDP KAMKHTTKEI TKYLEDKNVD VIVGPEARGF 70 80 90 100 110 120 LFGIPVAHEL DIGFVPVRKP GKLPYKTFSV DYALEYGADS LEIHSDGIEK GQNVAIVDDL 130 140 150 160 170 LATGGTVLGV SKLVEKLGGH VSALNFVIEL TELKGRDKLK GYGIQSLVKY DL

References

[1]

"Complete sequence of chromosome of Methanococcus maripaludis C5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000609 Genomic DNA. Translation: ABO35221.1.
RefSeq	YP_001097436.1. NC_009135.1.
3D structure databases
ProteinModelPortal	A4FYD7.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FYD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4927488.
GenomeReviews	Gene locus MmarC5_0915 in contig CP000609_GR.
KEGG	mmq:MmarC5_0915.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG15310.
HOGENOM	HBG703830.
OMA	MNAACEL.
PhylomeDB	A4FYD7.
ProtClustDB	PRK12560.
Enzyme and pathway databases
BioCyc	MMAR402880:MMARC5_0915-MONOMER.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. Apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT1_METM5

Accession

Primary (citable) accession number: A4FYD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program