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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei650ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-891-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MmarC5_0879
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348441 – 955Leucine--tRNA ligaseAdd BLAST955

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0879

Structurei

3D structure databases

ProteinModelPortaliA4FYA3
SMRiA4FYA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi647 – 651"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4FYA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNGVNEGT GHKSVDLIQI MDKWQKKWTE AKIFEAEHDL RDKFFITAAF
60 70 80 90 100
PYLNGVLHAG HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN
110 120 130 140 150
QIKDRKEDII WAYNNLHNIP MDELLKLKTP EAIVECFSKK ATEAFKRMGF
160 170 180 190 200
SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG HITKGSHPVR YCPKCENPVE
210 220 230 240 250
DHDLLHGEES TTVEYSLIKF TSEFDGKEII MPMATLRPET LFGVTNAWVN
260 270 280 290 300
PNEIYVMAKV HDEIQKLDGE DVELKYNGIW IVGKECADKL KEQDRKIEIL
310 320 330 340 350
KEIKGNELLG LKIKNPVTKK EVPLLPADFV EMGIGTGWVM SVPAHAPYDY
360 370 380 390 400
VALRDLGKIE EVGLIPLIEI EGYDKYPAKE IVEKLGVKDQ NDDELLEQAT
410 420 430 440 450
SKIYKDEFHK GKLNENCGEY AGISVKDIKE KLTKDYLNSN IAEIMYEFSE
460 470 480 490 500
QKVVCRCGEK CIIKTVKGQW FINYSDENWK KLAHECIDNM NFAPENIRQE
510 520 530 540 550
FHNKVDWMKD KACARKKGLG TILPFDENWI IESLSDSTIY MAYYTIARFI
560 570 580 590 600
NEGLTPEQLI PELFEYVYLG NGNVEEITKN SNISKETIEE MRKEFLYYYP
610 620 630 640 650
LDWRCSAKDL IPNHLTFMIF NHVALFGREH WPRGIEINGY VTIEGKKLSK
660 670 680 690 700
SKGPVLPVSE VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK
710 720 730 740 750
LYELAVSVME EEKTEKELSL IDKWLLHKTY SSINGAETAY EEFQLRKIGL
760 770 780 790 800
MFYELINDLR WYKRRGGENN NVLKEVVEIW TKLLSPVTPH LCEEIWEKLG
810 820 830 840 850
YAGFISQELY PEIKLEMVNE DLELGEEFIK SAMEDIRNIN GVAKINPEKM
860 870 880 890 900
YLYTADDWKY DLLEFMNENS EKNVKALIPM VMKEDKFKRH GKEVMKLINE
910 920 930 940 950
IMKIGVKKAI AEVEILENAK TFIESEFDCE VIVNGEDVKG KKKFAIPYKP

AIYME
Length:955
Mass (Da):110,927
Last modified:April 17, 2007 - v1
Checksum:iFF89DC413B300682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO35187.1
RefSeqiWP_011868641.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO35187; ABO35187; MmarC5_0879
GeneIDi4929284
KEGGimmq:MmarC5_0879

Similar proteinsi

Entry informationi

Entry nameiSYL_METM5
AccessioniPrimary (citable) accession number: A4FYA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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