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A4FYA3

- SYL_METM5

UniProt

A4FYA3 - SYL_METM5

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Protein

Leucine--tRNA ligase

Gene
leuS, MmarC5_0879
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei650 – 6501ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-893-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MmarC5_0879
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Leucine--tRNA ligaseUniRule annotationPRO_0000334844Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0879.

Structurei

3D structure databases

ProteinModelPortaliA4FYA3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionUniRule annotationAdd
BLAST
Motifi647 – 6515"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FYA3-1 [UniParc]FASTAAdd to Basket

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MDQNGVNEGT GHKSVDLIQI MDKWQKKWTE AKIFEAEHDL RDKFFITAAF    50
PYLNGVLHAG HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN 100
QIKDRKEDII WAYNNLHNIP MDELLKLKTP EAIVECFSKK ATEAFKRMGF 150
SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG HITKGSHPVR YCPKCENPVE 200
DHDLLHGEES TTVEYSLIKF TSEFDGKEII MPMATLRPET LFGVTNAWVN 250
PNEIYVMAKV HDEIQKLDGE DVELKYNGIW IVGKECADKL KEQDRKIEIL 300
KEIKGNELLG LKIKNPVTKK EVPLLPADFV EMGIGTGWVM SVPAHAPYDY 350
VALRDLGKIE EVGLIPLIEI EGYDKYPAKE IVEKLGVKDQ NDDELLEQAT 400
SKIYKDEFHK GKLNENCGEY AGISVKDIKE KLTKDYLNSN IAEIMYEFSE 450
QKVVCRCGEK CIIKTVKGQW FINYSDENWK KLAHECIDNM NFAPENIRQE 500
FHNKVDWMKD KACARKKGLG TILPFDENWI IESLSDSTIY MAYYTIARFI 550
NEGLTPEQLI PELFEYVYLG NGNVEEITKN SNISKETIEE MRKEFLYYYP 600
LDWRCSAKDL IPNHLTFMIF NHVALFGREH WPRGIEINGY VTIEGKKLSK 650
SKGPVLPVSE VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK 700
LYELAVSVME EEKTEKELSL IDKWLLHKTY SSINGAETAY EEFQLRKIGL 750
MFYELINDLR WYKRRGGENN NVLKEVVEIW TKLLSPVTPH LCEEIWEKLG 800
YAGFISQELY PEIKLEMVNE DLELGEEFIK SAMEDIRNIN GVAKINPEKM 850
YLYTADDWKY DLLEFMNENS EKNVKALIPM VMKEDKFKRH GKEVMKLINE 900
IMKIGVKKAI AEVEILENAK TFIESEFDCE VIVNGEDVKG KKKFAIPYKP 950
AIYME 955
Length:955
Mass (Da):110,927
Last modified:April 17, 2007 - v1
Checksum:iFF89DC413B300682
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35187.1.
RefSeqiYP_001097402.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35187; ABO35187; MmarC5_0879.
GeneIDi4929284.
KEGGimmq:MmarC5_0879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35187.1 .
RefSeqi YP_001097402.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FYA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_0879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35187 ; ABO35187 ; MmarC5_0879 .
GeneIDi 4929284.
KEGGi mmq:MmarC5_0879.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MMAR402880:GJ2R-893-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiSYL_METM5
AccessioniPrimary (citable) accession number: A4FYA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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