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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei261 – 2611By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 2818NADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336)
Alternative name(s):
UDP-ManNAc 6-dehydrogenase
Gene namesi
Name:wecC
Ordered Locus Names:MmarC5_0870
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427UDP-N-acetyl-D-mannosamine dehydrogenasePRO_0000337837Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi402880.MmarC5_0870.

Structurei

3D structure databases

ProteinModelPortaliA4FY94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
HOGENOMiHOG000153774.
KOiK02472.
OMAiCPETVLP.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FY94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKHGNYNIN KICVIGLGYI GLPTASMLAN HGYEVVGVDV NEKRVNQIKN
60 70 80 90 100
GELKIEEPGL LTLVKGAINS KNLNVQTSAT EADAFIICVP TPALENEDGS
110 120 130 140 150
KKCDLTYVMG AVQNIIPFLK EGNLIVIEST IPPEITKKIY ETIDKKIYVA
160 170 180 190 200
HCPERVLPGK ILKELVENDR IIGGINKKSA EMAKEIYKSF VEGKIYITDS
210 220 230 240 250
NTAEMVKLME NTYRDINIAL ANEFAKICDE IGVNVWDAIK IANKHPRVNI
260 270 280 290 300
LNPGPGVGGH CISIDPWFIV EKTNNAKFIR AARELNDNMP AYVCKSVLSE
310 320 330 340 350
LKKHGIKKPK ISVFGATYKG NVEDTRESPS KNVIEMLLKN GVTVSTFDPH
360 370 380 390 400
ATCFEYPLST LDECISGSDC IVVLTDHDAF KNIKKDDIDE ICPKLKNKIV
410 420
FDTKNILEHN LWKRAGFTVK LLGNGAW
Length:427
Mass (Da):47,374
Last modified:April 17, 2007 - v1
Checksum:iEC019825C3816394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35178.1.
RefSeqiWP_011868632.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35178; ABO35178; MmarC5_0870.
GeneIDi4928426.
KEGGimmq:MmarC5_0870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35178.1.
RefSeqiWP_011868632.1. NC_009135.1.

3D structure databases

ProteinModelPortaliA4FY94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_0870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35178; ABO35178; MmarC5_0870.
GeneIDi4928426.
KEGGimmq:MmarC5_0870.

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
HOGENOMiHOG000153774.
KOiK02472.
OMAiCPETVLP.

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-884-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWECC_METM5
AccessioniPrimary (citable) accession number: A4FY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.