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A4FY69

- ASPD_METM5

UniProt

A4FY69 - ASPD_METM5

Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241NAD; via amide nitrogenUniRule annotation
    Binding sitei190 – 1901NADUniRule annotation
    Active sitei218 – 2181UniRule annotation

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciMMAR402880:GJ2R-858-MONOMER.
    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
    Gene namesi
    Name:nadXUniRule annotation
    Ordered Locus Names:MmarC5_0845
    OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
    Taxonomic identifieri402880 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000253: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Probable L-aspartate dehydrogenasePRO_1000067306Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402880.MmarC5_0845.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FY69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000206326.
    KOiK06989.
    OMAiFHAKIEN.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01265. NadX.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4FY69-1 [UniParc]FASTAAdd to Basket

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    MLKVGVVGCG AIASLITKAL MSDRLNKAEV LAFYDGNLEK AEKLAMETGA    50
    DFCRSLDELV SKDLDLIVEC ASVTAVEDTV IKSLNNGKDV IIMSVGAFAD 100
    KDLFLKLYKL AEKLERKIYI PSGAVAGIDA VKSGSLGKIS DVTLTTTKPV 150
    HGLKNALEEQ GLNTDEIKEP KTVFEGTVFE AISKFPQNIN VSVVLSLASR 200
    YPAKVKIIAD PCAVVNRHEI FVKGSIGTIK TCVENNPCRD NPKTSALAAY 250
    SVIRLIKDLS EPIRIGT 267
    Length:267
    Mass (Da):28,716
    Last modified:April 17, 2007 - v1
    Checksum:iF8CCA8263E10E6D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35153.1.
    RefSeqiYP_001097368.1. NC_009135.1.

    Genome annotation databases

    EnsemblBacteriaiABO35153; ABO35153; MmarC5_0845.
    GeneIDi4929041.
    KEGGimmq:MmarC5_0845.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35153.1 .
    RefSeqi YP_001097368.1. NC_009135.1.

    3D structure databases

    ProteinModelPortali A4FY69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402880.MmarC5_0845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO35153 ; ABO35153 ; MmarC5_0845 .
    GeneIDi 4929041.
    KEGGi mmq:MmarC5_0845.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000206326.
    KOi K06989.
    OMAi FHAKIEN.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .
    BioCyci MMAR402880:GJ2R-858-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01265. NadX.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsi TIGR03855. NAD_NadX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C5 / ATCC BAA-1333.

    Entry informationi

    Entry nameiASPD_METM5
    AccessioniPrimary (citable) accession number: A4FY69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3