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A4FY19 (DNLI_METM5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MmarC5_0793
OrganismMethanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]
Taxonomic identifier402880 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573DNA ligase HAMAP-Rule MF_00407
PRO_1000049870

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2721ATP By similarity
Binding site3011ATP By similarity
Binding site3421ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4FY19 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: BC74B0A7585AECA8

FASTA57365,893
        10         20         30         40         50         60 
MLFNDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI GRVFAEFENK 

        70         80         90        100        110        120 
EIGIGPNLLL EAVKTTGISE KDLKAEIKKT GDIGTAVENL SSNIKQVSLF SQPLTLEEMY 

       130        140        150        160        170        180 
STLKKLSEIE GNSSQKKKIR IISNLLILAN PVESRYISRL ILEDMRIGMN IPTILASFSN 

       190        200        210        220        230        240 
YFNVNKENVE KIYAVTNDIG LLGEKLISGS DIENDSELHL KVFRPIKPML AQLTPSIEDA 

       250        260        270        280        290        300 
IIETKIPQFE TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVEEIKK IDIDNIILEG 

       310        320        330        340        350        360 
ECVAMDLSSG KPRPFQDILR RFRRKYDINK MAEKIALRIY FFDVLYYNRG LIDTPLRNRR 

       370        380        390        400        410        420 
EILEKLFGTN DWDTELEKIE KEILSKKMLF SSFKLNSDDP NLAKEFFNWS LSIGHEGVMI 

       430        440        450        460        470        480 
KNPDAPYTPG SRVKTMYKVK PTLENLDVVV TRAKIGMGKR KDWYGSYEIS VKDDESNLHV 

       490        500        510        520        530        540 
IGNVGSGLTE DDLERLTKIV NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR 

       550        560        570 
FPRVVQIRED KSINDINTLD DVKKIYDIER NRK 

« Hide

References

[1]"Complete sequence of chromosome of Methanococcus maripaludis C5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000609 Genomic DNA. Translation: ABO35103.1.
RefSeqYP_001097318.1. NC_009135.1.

3D structure databases

ProteinModelPortalA4FY19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402880.MmarC5_0793.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO35103; ABO35103; MmarC5_0793.
GeneID4928716.
KEGGmmq:MmarC5_0793.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMANPVESRY.
ProtClustDBCLSK876100.

Enzyme and pathway databases

BioCycMMAR402880:GJ2R-806-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_METM5
AccessionPrimary (citable) accession number: A4FY19
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families