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Protein

DNA ligase

Gene

lig

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei272ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MmarC5_0793
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498701 – 573DNA ligaseAdd BLAST573

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0793.

Structurei

3D structure databases

ProteinModelPortaliA4FY19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGMNIPTI.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FY19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFNDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI
60 70 80 90 100
GRVFAEFENK EIGIGPNLLL EAVKTTGISE KDLKAEIKKT GDIGTAVENL
110 120 130 140 150
SSNIKQVSLF SQPLTLEEMY STLKKLSEIE GNSSQKKKIR IISNLLILAN
160 170 180 190 200
PVESRYISRL ILEDMRIGMN IPTILASFSN YFNVNKENVE KIYAVTNDIG
210 220 230 240 250
LLGEKLISGS DIENDSELHL KVFRPIKPML AQLTPSIEDA IIETKIPQFE
260 270 280 290 300
TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVEEIKK IDIDNIILEG
310 320 330 340 350
ECVAMDLSSG KPRPFQDILR RFRRKYDINK MAEKIALRIY FFDVLYYNRG
360 370 380 390 400
LIDTPLRNRR EILEKLFGTN DWDTELEKIE KEILSKKMLF SSFKLNSDDP
410 420 430 440 450
NLAKEFFNWS LSIGHEGVMI KNPDAPYTPG SRVKTMYKVK PTLENLDVVV
460 470 480 490 500
TRAKIGMGKR KDWYGSYEIS VKDDESNLHV IGNVGSGLTE DDLERLTKIV
510 520 530 540 550
NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR FPRVVQIRED
560 570
KSINDINTLD DVKKIYDIER NRK
Length:573
Mass (Da):65,893
Last modified:April 17, 2007 - v1
Checksum:iBC74B0A7585AECA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35103.1.
RefSeqiWP_011868557.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35103; ABO35103; MmarC5_0793.
GeneIDi4928716.
KEGGimmq:MmarC5_0793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35103.1.
RefSeqiWP_011868557.1. NC_009135.1.

3D structure databases

ProteinModelPortaliA4FY19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_0793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35103; ABO35103; MmarC5_0793.
GeneIDi4928716.
KEGGimmq:MmarC5_0793.

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGMNIPTI.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI_METM5
AccessioniPrimary (citable) accession number: A4FY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.