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A4FY19

- DNLI_METM5

UniProt

A4FY19 - DNLI_METM5

Protein

DNA ligase

Gene

lig

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei272 – 2721ATPUniRule annotation
    Binding sitei301 – 3011ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei432 – 4321ATPUniRule annotation
    Binding sitei438 – 4381ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR402880:GJ2R-806-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:MmarC5_0793
    OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
    Taxonomic identifieri402880 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000253: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573DNA ligasePRO_1000049870Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402880.MmarC5_0793.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FY19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FY19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFNDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI    50
    GRVFAEFENK EIGIGPNLLL EAVKTTGISE KDLKAEIKKT GDIGTAVENL 100
    SSNIKQVSLF SQPLTLEEMY STLKKLSEIE GNSSQKKKIR IISNLLILAN 150
    PVESRYISRL ILEDMRIGMN IPTILASFSN YFNVNKENVE KIYAVTNDIG 200
    LLGEKLISGS DIENDSELHL KVFRPIKPML AQLTPSIEDA IIETKIPQFE 250
    TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVEEIKK IDIDNIILEG 300
    ECVAMDLSSG KPRPFQDILR RFRRKYDINK MAEKIALRIY FFDVLYYNRG 350
    LIDTPLRNRR EILEKLFGTN DWDTELEKIE KEILSKKMLF SSFKLNSDDP 400
    NLAKEFFNWS LSIGHEGVMI KNPDAPYTPG SRVKTMYKVK PTLENLDVVV 450
    TRAKIGMGKR KDWYGSYEIS VKDDESNLHV IGNVGSGLTE DDLERLTKIV 500
    NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR FPRVVQIRED 550
    KSINDINTLD DVKKIYDIER NRK 573
    Length:573
    Mass (Da):65,893
    Last modified:April 17, 2007 - v1
    Checksum:iBC74B0A7585AECA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35103.1.
    RefSeqiYP_001097318.1. NC_009135.1.

    Genome annotation databases

    EnsemblBacteriaiABO35103; ABO35103; MmarC5_0793.
    GeneIDi4928716.
    KEGGimmq:MmarC5_0793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000609 Genomic DNA. Translation: ABO35103.1 .
    RefSeqi YP_001097318.1. NC_009135.1.

    3D structure databases

    ProteinModelPortali A4FY19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402880.MmarC5_0793.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO35103 ; ABO35103 ; MmarC5_0793 .
    GeneIDi 4928716.
    KEGGi mmq:MmarC5_0793.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MMAR402880:GJ2R-806-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C5 / ATCC BAA-1333.

    Entry informationi

    Entry nameiDNLI_METM5
    AccessioniPrimary (citable) accession number: A4FY19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3