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Protein

DNA ligase

Gene

lig

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei272ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-804-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MmarC5_0793
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498701 – 573DNA ligaseAdd BLAST573

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0793

Structurei

3D structure databases

ProteinModelPortaliA4FY19
SMRiA4FY19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A4FY19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFNDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI
60 70 80 90 100
GRVFAEFENK EIGIGPNLLL EAVKTTGISE KDLKAEIKKT GDIGTAVENL
110 120 130 140 150
SSNIKQVSLF SQPLTLEEMY STLKKLSEIE GNSSQKKKIR IISNLLILAN
160 170 180 190 200
PVESRYISRL ILEDMRIGMN IPTILASFSN YFNVNKENVE KIYAVTNDIG
210 220 230 240 250
LLGEKLISGS DIENDSELHL KVFRPIKPML AQLTPSIEDA IIETKIPQFE
260 270 280 290 300
TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVEEIKK IDIDNIILEG
310 320 330 340 350
ECVAMDLSSG KPRPFQDILR RFRRKYDINK MAEKIALRIY FFDVLYYNRG
360 370 380 390 400
LIDTPLRNRR EILEKLFGTN DWDTELEKIE KEILSKKMLF SSFKLNSDDP
410 420 430 440 450
NLAKEFFNWS LSIGHEGVMI KNPDAPYTPG SRVKTMYKVK PTLENLDVVV
460 470 480 490 500
TRAKIGMGKR KDWYGSYEIS VKDDESNLHV IGNVGSGLTE DDLERLTKIV
510 520 530 540 550
NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR FPRVVQIRED
560 570
KSINDINTLD DVKKIYDIER NRK
Length:573
Mass (Da):65,893
Last modified:April 17, 2007 - v1
Checksum:iBC74B0A7585AECA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO35103.1
RefSeqiWP_011868557.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO35103; ABO35103; MmarC5_0793
GeneIDi4928716
KEGGimmq:MmarC5_0793

Similar proteinsi

Entry informationi

Entry nameiDNLI_METM5
AccessioniPrimary (citable) accession number: A4FY19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health