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A4FY19

- DNLI_METM5

UniProt

A4FY19 - DNLI_METM5

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Protein
DNA ligase
Gene
lig, MmarC5_0793
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarity
Active sitei252 – 2521N6-AMP-lysine intermediate By similarity
Binding sitei257 – 2571ATP By similarity
Binding sitei272 – 2721ATP By similarity
Binding sitei301 – 3011ATP By similarity
Binding sitei342 – 3421ATP By similarity
Binding sitei432 – 4321ATP By similarity
Binding sitei438 – 4381ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:MmarC5_0793
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573DNA ligaseUniRule annotation
PRO_1000049870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0793.

Structurei

3D structure databases

ProteinModelPortaliA4FY19.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FY19-1 [UniParc]FASTAAdd to Basket

« Hide

MLFNDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI    50
GRVFAEFENK EIGIGPNLLL EAVKTTGISE KDLKAEIKKT GDIGTAVENL 100
SSNIKQVSLF SQPLTLEEMY STLKKLSEIE GNSSQKKKIR IISNLLILAN 150
PVESRYISRL ILEDMRIGMN IPTILASFSN YFNVNKENVE KIYAVTNDIG 200
LLGEKLISGS DIENDSELHL KVFRPIKPML AQLTPSIEDA IIETKIPQFE 250
TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVEEIKK IDIDNIILEG 300
ECVAMDLSSG KPRPFQDILR RFRRKYDINK MAEKIALRIY FFDVLYYNRG 350
LIDTPLRNRR EILEKLFGTN DWDTELEKIE KEILSKKMLF SSFKLNSDDP 400
NLAKEFFNWS LSIGHEGVMI KNPDAPYTPG SRVKTMYKVK PTLENLDVVV 450
TRAKIGMGKR KDWYGSYEIS VKDDESNLHV IGNVGSGLTE DDLERLTKIV 500
NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR FPRVVQIRED 550
KSINDINTLD DVKKIYDIER NRK 573
Length:573
Mass (Da):65,893
Last modified:April 17, 2007 - v1
Checksum:iBC74B0A7585AECA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35103.1.
RefSeqiYP_001097318.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35103; ABO35103; MmarC5_0793.
GeneIDi4928716.
KEGGimmq:MmarC5_0793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35103.1 .
RefSeqi YP_001097318.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FY19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_0793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35103 ; ABO35103 ; MmarC5_0793 .
GeneIDi 4928716.
KEGGi mmq:MmarC5_0793.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MMAR402880:GJ2R-806-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiDNLI_METM5
AccessioniPrimary (citable) accession number: A4FY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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