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Protein

tRNA (pseudouridine(54)-N(1))-methyltransferase

Gene

trmY

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(54) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylpseudouridine(54) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei153 – 1531S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei186 – 1861S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-744-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (pseudouridine(54)-N(1))-methyltransferaseUniRule annotation (EC:2.1.1.257UniRule annotation)
Gene namesi
Name:trmYUniRule annotation
Ordered Locus Names:MmarC5_0731
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198tRNA (pseudouridine(54)-N(1))-methyltransferasePRO_1000025468Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_0731.

Structurei

3D structure databases

ProteinModelPortaliA4FXV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1816S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the methyltransferase superfamily. TrmY family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01239. Archaea.
COG1901. LUCA.
HOGENOMiHOG000244970.
KOiK16317.
OMAiLGDHIGL.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00587. tRNA_methyltr_TrmY.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR007158. TrmY.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF04013. Methyltrn_RNA_2. 1 hit.
[Graphical view]
SUPFAMiSSF75217. SSF75217. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FXV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEFIIKANK TVTNGEINLK DLPGSSGRLD LICRCVNSAF FLSHDLRRDT
60 70 80 90 100
IFYSVLYGPP NPPIALQFVG NELKRVSPDE RSIALFIKKA LEKDASELWK
110 120 130 140 150
ESTSGIYSSK WEFRDIILKK KNEGKRIFYL HLNGKPLENF EFKNDEDFVF
160 170 180 190
ILGDHIGIGE EDEEFLEEIG AEKISLSPLE LHADHCIILV HNILDKLK
Length:198
Mass (Da):22,693
Last modified:April 17, 2007 - v1
Checksum:i75499433CAD39E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35041.1.
RefSeqiWP_011868495.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35041; ABO35041; MmarC5_0731.
GeneIDi4928971.
KEGGimmq:MmarC5_0731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO35041.1.
RefSeqiWP_011868495.1. NC_009135.1.

3D structure databases

ProteinModelPortaliA4FXV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_0731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO35041; ABO35041; MmarC5_0731.
GeneIDi4928971.
KEGGimmq:MmarC5_0731.

Phylogenomic databases

eggNOGiarCOG01239. Archaea.
COG1901. LUCA.
HOGENOMiHOG000244970.
KOiK16317.
OMAiLGDHIGL.

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-744-MONOMER.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00587. tRNA_methyltr_TrmY.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR007158. TrmY.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF04013. Methyltrn_RNA_2. 1 hit.
[Graphical view]
SUPFAMiSSF75217. SSF75217. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiTRMY_METM5
AccessioniPrimary (citable) accession number: A4FXV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: December 9, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.