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Protein

tRNA (pseudouridine(54)-N(1))-methyltransferase

Gene

trmY

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(54) in tRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine(54) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei153S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei186S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-741-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (pseudouridine(54)-N(1))-methyltransferaseUniRule annotation (EC:2.1.1.257UniRule annotation)
Gene namesi
Name:trmYUniRule annotation
Ordered Locus Names:MmarC5_0731
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000254681 – 198tRNA (pseudouridine(54)-N(1))-methyltransferaseAdd BLAST198

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_0731

Structurei

3D structure databases

ProteinModelPortaliA4FXV7
SMRiA4FXV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 181S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the methyltransferase superfamily. TrmY family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01239 Archaea
COG1901 LUCA
HOGENOMiHOG000244970
KOiK16317
OMAiAGRMDIL
OrthoDBiPOG093Z0BI4

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
HAMAPiMF_00587 tRNA_methyltr_TrmY, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR007158 TrmY
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR40703 PTHR40703, 1 hit
PfamiView protein in Pfam
PF04013 Methyltrn_RNA_2, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit

Sequencei

Sequence statusi: Complete.

A4FXV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEFIIKANK TVTNGEINLK DLPGSSGRLD LICRCVNSAF FLSHDLRRDT
60 70 80 90 100
IFYSVLYGPP NPPIALQFVG NELKRVSPDE RSIALFIKKA LEKDASELWK
110 120 130 140 150
ESTSGIYSSK WEFRDIILKK KNEGKRIFYL HLNGKPLENF EFKNDEDFVF
160 170 180 190
ILGDHIGIGE EDEEFLEEIG AEKISLSPLE LHADHCIILV HNILDKLK
Length:198
Mass (Da):22,693
Last modified:April 17, 2007 - v1
Checksum:i75499433CAD39E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO35041.1
RefSeqiWP_011868495.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO35041; ABO35041; MmarC5_0731
GeneIDi4928971
KEGGimmq:MmarC5_0731

Similar proteinsi

Entry informationi

Entry nameiTRMY_METM5
AccessioniPrimary (citable) accession number: A4FXV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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