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A4FXV0

- DAPF_METM5

UniProt

A4FXV0 - DAPF_METM5

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Protein
Diaminopimelate epimerase
Gene
dapF, MmarC5_0724
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Binding sitei62 – 621Substrate By similarity
Active sitei71 – 711Proton donor/acceptor By similarity
Binding sitei160 – 1601Substrate By similarity
Sitei162 – 1621Important for catalytic activity By similarity
Binding sitei193 – 1931Substrate By similarity
Sitei211 – 2111Important for catalytic activity By similarity
Active sitei220 – 2201Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-737-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:MmarC5_0724
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Diaminopimelate epimeraseUniRule annotation
PRO_1000124421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 220UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0724.

Structurei

3D structure databases

ProteinModelPortaliA4FXV0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate binding By similarity
Regioni71 – 733Substrate binding By similarity
Regioni211 – 2122Substrate binding By similarity
Regioni221 – 2222Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiERANTDE.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FXV0-1 [UniParc]FASTAAdd to Basket

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MKFTKMHGLG NDYIYVDAIS QKIENPNEIS KFVSDRHFGI GSDGLVLILP    50
SDVADFKMRM FNSDGSEAEM CGNAIRCVGK FVYDKKMTDK STISIETLAG 100
IKVLEMTVEN GKVVLVKVDM GEPILKAETI PVLSEKHPVI DEEITAKDYC 150
YNFTCVSMGN PHAITYIENV EEFPLEKIGP LFEVHEKFPK KTNVEFVELI 200
DDSTVKMRVW ERGAGETLAC GTGACAVLTA SVLKGYVGRK ATVKLLGGDL 250
IIEWNEKDNH IYMTGPATTV FEGEIDI 277
Length:277
Mass (Da):30,689
Last modified:April 17, 2007 - v1
Checksum:i39FD4803EC384DB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35034.1.
RefSeqiYP_001097249.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO35034; ABO35034; MmarC5_0724.
GeneIDi4928508.
KEGGimmq:MmarC5_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO35034.1 .
RefSeqi YP_001097249.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FXV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_0724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO35034 ; ABO35034 ; MmarC5_0724 .
GeneIDi 4928508.
KEGGi mmq:MmarC5_0724.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi ERANTDE.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci MMAR402880:GJ2R-737-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiDAPF_METM5
AccessioniPrimary (citable) accession number: A4FXV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 17, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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