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A4FX33

- THIM_METM5

UniProt

A4FX33 - THIM_METM5

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, MmarC5_0447
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Substrate; via amide nitrogen By similarity
Binding sitei119 – 1191ATP By similarity
Binding sitei166 – 1661ATP By similarity
Binding sitei193 – 1931Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-458-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:MmarC5_0447
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Hydroxyethylthiazole kinaseUniRule annotationPRO_1000021520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0447.

Structurei

3D structure databases

ProteinModelPortaliA4FX33.
SMRiA4FX33. Positions 1-265.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiVSGTGCM.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FX33-1 [UniParc]FASTAAdd to Basket

« Hide

MDFVAKNLTK LRETNPLVQN ITNYVVMNST ANSLLALGAS PVMAHAMDEL    50
EEMVSIASAL VVNIGTLDEY WIPSMEKAAK IASDLKKPII LDPVGAGATK 100
LRTKTALKIL DFADISVLRG NFGEIAAVLG EHGKTRGVDS AAYDSNEAIE 150
LSKNAAKEFN TVSAVTGPVD YVSNGKEIYA ISNGHPMLSK VTGTGCASTS 200
IIGAFSAVDE PLKAAVSGLT VYGISAEMAF SEAPYPGTFQ AKVYDWLYRI 250
DEKLVFEKAK VNKFEI 266
Length:266
Mass (Da):28,434
Last modified:April 17, 2007 - v1
Checksum:iB6AA18D60B87E03D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO34762.1.
RefSeqiYP_001096977.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO34762; ABO34762; MmarC5_0447.
GeneIDi4928444.
KEGGimmq:MmarC5_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000609 Genomic DNA. Translation: ABO34762.1 .
RefSeqi YP_001096977.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FX33.
SMRi A4FX33. Positions 1-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_0447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO34762 ; ABO34762 ; MmarC5_0447 .
GeneIDi 4928444.
KEGGi mmq:MmarC5_0447.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi VSGTGCM.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci MMAR402880:GJ2R-458-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiTHIM_METM5
AccessioniPrimary (citable) accession number: A4FX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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