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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119Proton acceptorUniRule annotation1
Binding sitei137SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciMMAR402880:G1G8G-409-MONOMER
UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:MmarC5_0401
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000169481 – 239Ribose-5-phosphate isomerase AAdd BLAST239

Proteomic databases

PRIDEiA4FWY7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402880.MmarC5_0401

Structurei

3D structure databases

ProteinModelPortaliA4FWY7
SMRiA4FWY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 43Substrate bindingUniRule annotation4
Regioni96 – 99Substrate bindingUniRule annotation4
Regioni110 – 113Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01122 Archaea
COG0120 LUCA
HOGENOMiHOG000276368
KOiK01807
OMAiVAPMAYV
OrthoDBiPOG093Z0F8P

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

A4FWY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKKANDE VPTNSDSLKL KVAKQAAKLV KDEMVVGLGS GSTANLFIQE
60 70 80 90 100
LGKRIVEEEL YIYGVPTSFD SRMVASTAGI PLISLDQCGE IDIAVDGADE
110 120 130 140 150
VCKSTLSLIK GGGGCHTMEK IVDYHAKEFI VLADEGKLVD SLGDKTPVPL
160 170 180 190 200
EVIPFAYSTV LNKLLKMNTA PAIRTGSGKM GPVITDSGNM IIDVFISIDD
210 220 230
AEETENMLNN IPGVLENGVF SKCDKVLVGT SKKVEILKK
Length:239
Mass (Da):25,565
Last modified:April 17, 2007 - v1
Checksum:i62E7FC9389737A4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA Translation: ABO34716.1
RefSeqiWP_011868171.1, NC_009135.1

Genome annotation databases

EnsemblBacteriaiABO34716; ABO34716; MmarC5_0401
GeneIDi4927896
KEGGimmq:MmarC5_0401

Similar proteinsi

Entry informationi

Entry nameiRPIA_METM5
AccessioniPrimary (citable) accession number: A4FWY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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