A4FWS4 (PUR5_METM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	MmarC5_0337

Organism

Methanococcus maripaludis (strain C5 / ATCC BAA-1333) [Complete proteome] [HAMAP]

Taxonomic identifier

402880 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_A.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A		PRO_1000046446

Sequences

	Sequence		Length	Mass (Da)
	A4FWS4 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 251292469362481C	FASTA	349	38,190
	10 20 30 40 50 60 MVTYKDAGVD IYKEDKVIRA LASQIKFERN DAIKPADLKG HYAGAIEFGD YYLVLCTDGV 70 80 90 100 110 120 GSKMVVAEMA NKFDTVPIDM IAMNVNDAIC IGAEPVALVD YMAVEDITED IASQIGKGLN 130 140 150 160 170 180 DGIKESNINL IGGETASLPN MIKGVDLAGT VLAVVKKDEI VSGKEVKPGD LIVGLRSSGI 190 200 210 220 230 240 HSNGLSLARK VFFDIANLDV NSKLSHGKTV AEELLTPTKI YVKPVLEMIK QVNVKGLAHI 250 260 270 280 290 300 TGGGFRKLKR LNKEVCYKID ELPEILPIFK EIQNLGSVAD EEMFKTFNMG IGFCVIVDKE 310 320 330 340 DAEKIIEISN HHNIPAFVIG KIEDSVELNG ETKRETVLVE YNNKKMIME

References

[1]

"Complete sequence of chromosome of Methanococcus maripaludis C5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C5 / ATCC BAA-1333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000609 Genomic DNA. Translation: ABO34653.1.
RefSeq	YP_001096868.1. NC_009135.1.
3D structure databases
ProteinModelPortal	A4FWS4.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FWS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4928957.
GenomeReviews	Gene locus MmarC5_0337 in contig CP000609_GR.
KEGG	mmq:MmarC5_0337.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04189.
HOGENOM	HBG531222.
OMA	MENITGH.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	MMAR402880:MMARC5_0337-MONOMER.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_METM5

Accession

Primary (citable) accession number: A4FWS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program