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A4FWS4

- PUR5_METM5

UniProt

A4FWS4 - PUR5_METM5

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR402880:GJ2R-348-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:MmarC5_0337
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000253: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046446Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0337.

Structurei

3D structure databases

ProteinModelPortaliA4FWS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiAMNAASH.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FWS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTYKDAGVD IYKEDKVIRA LASQIKFERN DAIKPADLKG HYAGAIEFGD
60 70 80 90 100
YYLVLCTDGV GSKMVVAEMA NKFDTVPIDM IAMNVNDAIC IGAEPVALVD
110 120 130 140 150
YMAVEDITED IASQIGKGLN DGIKESNINL IGGETASLPN MIKGVDLAGT
160 170 180 190 200
VLAVVKKDEI VSGKEVKPGD LIVGLRSSGI HSNGLSLARK VFFDIANLDV
210 220 230 240 250
NSKLSHGKTV AEELLTPTKI YVKPVLEMIK QVNVKGLAHI TGGGFRKLKR
260 270 280 290 300
LNKEVCYKID ELPEILPIFK EIQNLGSVAD EEMFKTFNMG IGFCVIVDKE
310 320 330 340
DAEKIIEISN HHNIPAFVIG KIEDSVELNG ETKRETVLVE YNNKKMIME
Length:349
Mass (Da):38,190
Last modified:April 17, 2007 - v1
Checksum:i251292469362481C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO34653.1.
RefSeqiYP_001096868.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO34653; ABO34653; MmarC5_0337.
GeneIDi4928957.
KEGGimmq:MmarC5_0337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO34653.1 .
RefSeqi YP_001096868.1. NC_009135.1.

3D structure databases

ProteinModelPortali A4FWS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402880.MmarC5_0337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO34653 ; ABO34653 ; MmarC5_0337 .
GeneIDi 4928957.
KEGGi mmq:MmarC5_0337.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi AMNAASH.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci MMAR402880:GJ2R-348-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C5 / ATCC BAA-1333.

Entry informationi

Entry nameiPUR5_METM5
AccessioniPrimary (citable) accession number: A4FWS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3