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Protein

Lactaldehyde dehydrogenase

Gene

MmarC5_0090

Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.By similarity

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei274PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 225NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Gene namesi
Ordered Locus Names:MmarC5_0090
OrganismiMethanococcus maripaludis (strain C5 / ATCC BAA-1333)
Taxonomic identifieri402880 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000253 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425901 – 465Lactaldehyde dehydrogenaseAdd BLAST465

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi402880.MmarC5_0090.

Structurei

3D structure databases

ProteinModelPortaliA4FW36.
SMRiA4FW36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG01252. Archaea.
COG1012. LUCA.
HOGENOMiHOG000271509.
KOiK19266.
OMAiYEFFTEV.
OrthoDBiPOG093Z01H3.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FW36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDGKWILR EDIDVFDPYT LENIEKITAL DREETKSAIE VAEKNKEIMK
60 70 80 90 100
NLSPSKRYSI LMKIAEQISL KKDLFAKTIS IDVGKPIKQS KIEVDRTLTA
110 120 130 140 150
LKLSAFYAKE LRGETINSEN GLIFTKKEPL GVVGAITPFN FPLNLITHKI
160 170 180 190 200
GPAIATGNSV VLHPSSKAPI VAIYLTKIIE HVLKQMDVPR GIFNLATGNG
210 220 230 240 250
DIVGDEISKN DNINMVSFTG SVEVGESISK NAKMKKVALE LGGNNPMIVL
260 270 280 290 300
KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVLETF TKHVIEETKK
310 320 330 340 350
LILGNPLDTK TDIGPLISPE SALRIENLIK KSVNEGGEVL IGGNRQNSLI
360 370 380 390 400
SPAVINIDEN NILSKIETFG PVLPILKVKD SEEAVSIANN SKYGLQAGVF
410 420 430 440 450
TNDINKAMKI ADSLEYGGIM INSSPTFRKD NMPFGGVKKS GLGREGIKYT
460
VEEMCETKTI VIHNI
Length:465
Mass (Da):50,803
Last modified:April 17, 2007 - v1
Checksum:i37DC771138E8154A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000609 Genomic DNA. Translation: ABO34407.1.
RefSeqiWP_011867868.1. NC_009135.1.

Genome annotation databases

EnsemblBacteriaiABO34407; ABO34407; MmarC5_0090.
GeneIDi4928313.
KEGGimmq:MmarC5_0090.

Similar proteinsi

Entry informationi

Entry nameiLADH_METM5
AccessioniPrimary (citable) accession number: A4FW36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 17, 2007
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families