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Protein

NAC domain-containing protein 16

Gene

NAC016

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcriptional activator that promotes leaf senescence by up-regulating senescence-associated genes in response to developmental and stress-induced senescence signals. Functions in salt and oxidative stress-responsive signaling pathways. Binds to the promoter of NAC029/NAP and NAC059/ORS1 genes (PubMed:23926065).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi115 – 172PROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • positive regulation of leaf senescence Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • response to chitin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NAC domain-containing protein 161 Publication
Short name:
ANAC0161 Publication
Alternative name(s):
Protein NTM1-like 31 Publication
Gene namesi
Name:NAC016Imported
Synonyms:NTL31 Publication
Ordered Locus Names:At1g34180Imported
ORF Names:F23M19.14Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G34180
TAIRilocus:2026114 AT1G34180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Stay-green phenotype during senescence, salt stress and oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004324421 – 564NAC domain-containing protein 16Add BLAST564

Proteomic databases

PaxDbiA4FVP6

PTM databases

iPTMnetiA4FVP6

Expressioni

Tissue specificityi

Expressed in roots, rosette leaves, shoot apex, stems and flowers.1 Publication

Developmental stagei

Induced during normal senescence.1 Publication

Inductioni

By cold, salt, drought stress and methyl methanesulfonate (MMS) treatment.1 Publication

Gene expression databases

ExpressionAtlasiA4FVP6 baseline and differential
GenevisibleiA4FVP6 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G34180.2

Structurei

3D structure databases

ProteinModelPortaliA4FVP6
SMRiA4FVP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 166NACPROSITE-ProRule annotationAdd BLAST151

Domaini

The NAC domain includes a DNA binding domain and a dimerization domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFDC Eukaryota
ENOG410Y9FR LUCA
HOGENOMiHOG000253966
OrthoDBiEOG093606IX
PhylomeDBiA4FVP6

Family and domain databases

Gene3Di3.30.310.150, 1 hit
InterProiView protein in InterPro
IPR003441 NAC-dom
IPR036093 NAC_dom_sf
PfamiView protein in Pfam
PF02365 NAM, 1 hit
SUPFAMiSSF101941 SSF101941, 1 hit
PROSITEiView protein in PROSITE
PS51005 NAC, 1 hit

Sequencei

Sequence statusi: Complete.

A4FVP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSSRDSCF KAGKFSAPGF RFHPTDEELV VYYLKRKICC KKLRVNAIGV
60 70 80 90 100
VDVYKVDPSE LPGLSMLKTG DRQWFFFTPR NRKYPNAARS SRGTATGYWK
110 120 130 140 150
ATGKDRVIEY NSRSVGLKKT LVFYRGRAPN GERTDWVMHE YTMDEEELGR
160 170 180 190 200
CKNAKEYYAL YKLYKKSGAG PKNGEQYGAP FQEEEWVDSD SEDADSVAVP
210 220 230 240 250
DYPVVRYENG PCVDDTKFCN PVKLQLEDIE KLLNEIPDAP GVNQRQFDEF
260 270 280 290 300
VGVPQGNSAE VIQSTLLNNS SGEYIDPRTN GMFLPNGQLY NRDSSFQSHL
310 320 330 340 350
NSFEATSGMA PLLDNEKEEY IEMNDLLIPE LGASSTEKST EFLNHGEFGD
360 370 380 390 400
VNEYDQLFND ISVFQGTSTD LSCLSNFTNN TSGQRQQLLY EQFQYQTPEN
410 420 430 440 450
QLNNYMHPST TLNQFTDNMW FKDDQAALYV QPPQSSSGAF TSQSTGVMPE
460 470 480 490 500
SMNPTMSVNP QYKEGQNGGG TRSQFSSALW ELLESIPSTP ASACEGPLNQ
510 520 530 540 550
TFVRMSSFSR IRFNGTSVTS RKVTVAKKRI SNRGFLLLSI MGALCAIFWV
560
FKATVGVMGR PLLS
Length:564
Mass (Da):63,407
Last modified:April 17, 2007 - v1
Checksum:iA139CB879621F8A6
GO

Sequence cautioni

The sequence AAD39614 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AEE31683 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45V → I in AAM67294 (Ref. 5) Curated1
Sequence conflicti199V → I in AAM67294 (Ref. 5) Curated1
Sequence conflicti465G → V in AAM67294 (Ref. 5) Curated1
Sequence conflicti552K → I in AAM67294 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007454 Genomic DNA Translation: AAD39614.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31682.1
CP002684 Genomic DNA Translation: AEE31683.1 Sequence problems.
BT030344 mRNA Translation: ABO38757.1
AB493493 mRNA Translation: BAH30331.1
AY084860 mRNA Translation: AAM67294.1
PIRiA86466
RefSeqiNP_001077648.1, NM_001084179.1
NP_564439.1, NM_103141.4
UniGeneiAt.39788

Genome annotation databases

EnsemblPlantsiAT1G34180.1; AT1G34180.1; AT1G34180
GeneIDi840317
GrameneiAT1G34180.1; AT1G34180.1; AT1G34180
KEGGiath:AT1G34180

Similar proteinsi

Entry informationi

Entry nameiNAC16_ARATH
AccessioniPrimary (citable) accession number: A4FVP6
Secondary accession number(s): Q8LFG7, Q9XIC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 17, 2007
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health