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Protein

NAC domain-containing protein 16

Gene

NAC016

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcriptional activator that promotes leaf senescence by up-regulating senescence-associated genes in response to developmental and stress-induced senescence signals. Functions in salt and oxidative stress-responsive signaling pathways. Binds to the promoter of NAC029/NAP and NAC059/ORS1 genes (PubMed:23926065).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi115 – 17258PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of leaf senescence Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAC domain-containing protein 161 Publication
Short name:
ANAC0161 Publication
Alternative name(s):
Protein NTM1-like 31 Publication
Gene namesi
Name:NAC016Imported
Synonyms:NTL31 Publication
Ordered Locus Names:At1g34180Imported
ORF Names:F23M19.14Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G34180.

Subcellular locationi

  • Membrane By similarity; Single-pass membrane protein Sequence analysis
  • Nucleus PROSITE-ProRule annotationBy similarity

  • Note: Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon specific stress or signal, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei535 – 55521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Stay-green phenotype during senescence, salt stress and oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564NAC domain-containing protein 16PRO_0000432442Add
BLAST

Proteomic databases

PaxDbiA4FVP6.
PRIDEiA4FVP6.

PTM databases

iPTMnetiA4FVP6.

Expressioni

Tissue specificityi

Expressed in roots, rosette leaves, shoot apex, stems and flowers.1 Publication

Developmental stagei

Induced during normal senescence.1 Publication

Inductioni

By cold, salt, drought stress and methyl methanesulfonate (MMS) treatment.1 Publication

Gene expression databases

ExpressionAtlasiA4FVP6. baseline and differential.
GenevisibleiA4FVP6. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G34180.2.

Structurei

3D structure databases

ProteinModelPortaliA4FVP6.
SMRiA4FVP6. Positions 18-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 166151NACPROSITE-ProRule annotationAdd
BLAST

Domaini

The NAC domain includes a DNA binding domain and a dimerization domain.PROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 NAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFDC. Eukaryota.
ENOG410Y9FR. LUCA.
HOGENOMiHOG000253966.
OrthoDBiEOG093606IX.
PhylomeDBiA4FVP6.

Family and domain databases

InterProiIPR003441. NAC-dom.
[Graphical view]
PfamiPF02365. NAM. 1 hit.
[Graphical view]
SUPFAMiSSF101941. SSF101941. 1 hit.
PROSITEiPS51005. NAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FVP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSSRDSCF KAGKFSAPGF RFHPTDEELV VYYLKRKICC KKLRVNAIGV
60 70 80 90 100
VDVYKVDPSE LPGLSMLKTG DRQWFFFTPR NRKYPNAARS SRGTATGYWK
110 120 130 140 150
ATGKDRVIEY NSRSVGLKKT LVFYRGRAPN GERTDWVMHE YTMDEEELGR
160 170 180 190 200
CKNAKEYYAL YKLYKKSGAG PKNGEQYGAP FQEEEWVDSD SEDADSVAVP
210 220 230 240 250
DYPVVRYENG PCVDDTKFCN PVKLQLEDIE KLLNEIPDAP GVNQRQFDEF
260 270 280 290 300
VGVPQGNSAE VIQSTLLNNS SGEYIDPRTN GMFLPNGQLY NRDSSFQSHL
310 320 330 340 350
NSFEATSGMA PLLDNEKEEY IEMNDLLIPE LGASSTEKST EFLNHGEFGD
360 370 380 390 400
VNEYDQLFND ISVFQGTSTD LSCLSNFTNN TSGQRQQLLY EQFQYQTPEN
410 420 430 440 450
QLNNYMHPST TLNQFTDNMW FKDDQAALYV QPPQSSSGAF TSQSTGVMPE
460 470 480 490 500
SMNPTMSVNP QYKEGQNGGG TRSQFSSALW ELLESIPSTP ASACEGPLNQ
510 520 530 540 550
TFVRMSSFSR IRFNGTSVTS RKVTVAKKRI SNRGFLLLSI MGALCAIFWV
560
FKATVGVMGR PLLS
Length:564
Mass (Da):63,407
Last modified:April 17, 2007 - v1
Checksum:iA139CB879621F8A6
GO

Sequence cautioni

The sequence AAD39614 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AEE31683 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451V → I in AAM67294 (Ref. 5) Curated
Sequence conflicti199 – 1991V → I in AAM67294 (Ref. 5) Curated
Sequence conflicti465 – 4651G → V in AAM67294 (Ref. 5) Curated
Sequence conflicti552 – 5521K → I in AAM67294 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007454 Genomic DNA. Translation: AAD39614.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31682.1.
CP002684 Genomic DNA. Translation: AEE31683.1. Sequence problems.
BT030344 mRNA. Translation: ABO38757.1.
AB493493 mRNA. Translation: BAH30331.1.
AY084860 mRNA. Translation: AAM67294.1.
PIRiA86466.
RefSeqiNP_001077648.1. NM_001084179.1.
NP_564439.1. NM_103141.3.
UniGeneiAt.39788.

Genome annotation databases

EnsemblPlantsiAT1G34180.1; AT1G34180.1; AT1G34180.
AT1G34180.2; AT1G34180.2; AT1G34180.
GeneIDi840317.
GrameneiAT1G34180.1; AT1G34180.1; AT1G34180.
AT1G34180.2; AT1G34180.2; AT1G34180.
KEGGiath:AT1G34180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007454 Genomic DNA. Translation: AAD39614.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31682.1.
CP002684 Genomic DNA. Translation: AEE31683.1. Sequence problems.
BT030344 mRNA. Translation: ABO38757.1.
AB493493 mRNA. Translation: BAH30331.1.
AY084860 mRNA. Translation: AAM67294.1.
PIRiA86466.
RefSeqiNP_001077648.1. NM_001084179.1.
NP_564439.1. NM_103141.3.
UniGeneiAt.39788.

3D structure databases

ProteinModelPortaliA4FVP6.
SMRiA4FVP6. Positions 18-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G34180.2.

PTM databases

iPTMnetiA4FVP6.

Proteomic databases

PaxDbiA4FVP6.
PRIDEiA4FVP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G34180.1; AT1G34180.1; AT1G34180.
AT1G34180.2; AT1G34180.2; AT1G34180.
GeneIDi840317.
GrameneiAT1G34180.1; AT1G34180.1; AT1G34180.
AT1G34180.2; AT1G34180.2; AT1G34180.
KEGGiath:AT1G34180.

Organism-specific databases

TAIRiAT1G34180.

Phylogenomic databases

eggNOGiENOG410IFDC. Eukaryota.
ENOG410Y9FR. LUCA.
HOGENOMiHOG000253966.
OrthoDBiEOG093606IX.
PhylomeDBiA4FVP6.

Miscellaneous databases

PROiA4FVP6.

Gene expression databases

ExpressionAtlasiA4FVP6. baseline and differential.
GenevisibleiA4FVP6. AT.

Family and domain databases

InterProiIPR003441. NAC-dom.
[Graphical view]
PfamiPF02365. NAM. 1 hit.
[Graphical view]
SUPFAMiSSF101941. SSF101941. 1 hit.
PROSITEiPS51005. NAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAC16_ARATH
AccessioniPrimary (citable) accession number: A4FVP6
Secondary accession number(s): Q8LFG7, Q9XIC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.