EIF2C2

Functionⁱ

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

gene silencing by RNA Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	RNA-mediated gene silencingSAAS annotation

Biological process

RNA-mediated gene silencingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: eIF2C2 proteinImported
Gene namesⁱ	Name:EIF2C2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27694.

PharmGKBⁱ

PA27694.

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	A4FVC0.
PeptideAtlas More...PeptideAtlasⁱ	A4FVC0.
PRIDEⁱ	A4FVC0.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	A4FVC0. HS.

Genevisibleⁱ

A4FVC0. HS.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	A4FVC0. 11 interactors.

IntActⁱ

A4FVC0. 11 interactors.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	184 – 297	PAZInterPro annotationAdd BLAST		114
Domainⁱ	466 – 767	PiwiInterPro annotationAdd BLAST		302

Sequence similaritiesⁱ

Belongs to the argonaute family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1041. Eukaryota. ENOG410XP07. LUCA.
HOVERGENⁱ	HBG006101.
KEGG Orthology (KO) More...KOⁱ	K11593.

Family and domain databases

Gene3Dⁱ	3.30.420.10. 1 hit.
InterProⁱ	View protein in InterPro IPR014811. ArgoL1. IPR032472. ArgoL2. IPR032473. Argonaute_Mid_dom. IPR032474. Argonaute_N. IPR003100. PAZ_dom. IPR003165. Piwi. IPR012337. RNaseH-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08699. ArgoL1. 1 hit. PF16488. ArgoL2. 1 hit. PF16487. ArgoMid. 1 hit. PF16486. ArgoN. 1 hit. PF02170. PAZ. 1 hit. PF02171. Piwi. 1 hit.
SMARTⁱ	View protein in SMART SM01163. DUF1785. 1 hit. SM00949. PAZ. 1 hit. SM00950. Piwi. 1 hit.
SUPFAMⁱ	SSF101690. SSF101690. 1 hit. SSF53098. SSF53098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50821. PAZ. 1 hit. PS50822. PIWI. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

A4FVC0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
RPPLGPGAPR RRHHVLGSRP REIVEHMVQH FKTQIFGDRK PVFDGRKNLY 
        60         70         80         90        100
TAMPLPIGRD KVELEVTLPG EGKDRIFKVS IKWVSCVSLQ ALHDALSGRL 
       110        120        130        140        150
PSVPFETIQA LDVVMRHLPS MRYTPVGRSF FTASEGCSNP LGGGREVWFG 
       160        170        180        190        200
FHQSVRPSLW KMMLNIDVSA TAFYKAQPVI EFVCEVLDFK SIEEQQKPLT 
       210        220        230        240        250
DSQRVKFTKE IKGLKVEITH CGQMKRKYRV CNVTRRPASH QTFPLQQESG 
       260        270        280        290        300
QTVECTVAQY FKDRHKLVLR YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR 
       310        320        330        340        350
CIKKLTDNQT STMIRATARS APDRQEEISK LMRSASFNTD PYVREFGIMV 
       360        370        380        390        400
KDEMTDVTGR VLQPPSILYG GRNKAIATPV QGVWDMRNKQ FHTGIEIKVW 
       410        420        430        440        450
AIACFAPQRQ CTEVHLKSFT EQLRKISRDA GMPIQGQPCF CKYAQGADSV 
       460        470        480        490        500
EPMFRHLKNT YAGLQLVVVI LPGKTPVYAE VKRVGDTVLG MATQCVQMKN 
       510        520        530        540        550
VQRTTPQTLS NLCLKINVKL GGVNNILLPQ GRPPVFQQPV IFLGADVTHP 
       560        570        580        590        600
PAGDGKKPSI AAVVGSMDAH PNRYCATVRV QQHRQEIIQD LAAMVRELLI 
       610        620        630        640        650
QFYKSTRFKP TRIIFYRDGV SEGQFQQVLH HELLAIREAC IKLEKDYQPG 
       660        670        680        690        700
ITFIVVQKRH HTRLFCTDKN ERVGKSGNIP AGTTVDTKIT HPTEFDFYLC 
       710        720        730        740        750
SHAGIQGTSR PSHYHVLWDD NRFSSDELQI LTYQLCHTYV RCTRSVSIPA 
       760        770        780        790        800
PAYYAHLVAF RARYHLVDKE HDSAEGSHTS GQSNGRDHQA LAKAVQVHQD 

TLRTMYFA

Length:808

Mass (Da):91,497

Last modified:April 17, 2007 - v1

Checksum:ⁱ7D58FD57997FAC7D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC125213 mRNA. Translation: AAI25214.1.
UniGeneⁱ	Hs.660189. Hs.743313.

Genome annotation databases

KEGGⁱ	hsa:27161.

KEGGⁱ

hsa:27161.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC125213 mRNA. Translation: AAI25214.1.
UniGeneⁱ	Hs.660189. Hs.743313.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	A4FVC0. 11 interactors.

IntActⁱ

A4FVC0. 11 interactors.

Proteomic databases

PaxDbⁱ	A4FVC0.
PeptideAtlas More...PeptideAtlasⁱ	A4FVC0.
PRIDEⁱ	A4FVC0.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27161.
Structural Biology Knowledgebase	Search...

Genome annotation databases

KEGGⁱ	hsa:27161.

KEGGⁱ

hsa:27161.

Organism-specific databases

PharmGKBⁱ	PA27694.

PharmGKBⁱ

PA27694.

Phylogenomic databases

eggNOGⁱ	KOG1041. Eukaryota. ENOG410XP07. LUCA.
HOVERGENⁱ	HBG006101.
KEGG Orthology (KO) More...KOⁱ	K11593.

Miscellaneous databases

GenomeRNAiⁱ	27161.

GenomeRNAiⁱ

27161.

Gene expression databases

Genevisibleⁱ	A4FVC0. HS.

Genevisibleⁱ

A4FVC0. HS.

Family and domain databases

Gene3Dⁱ	3.30.420.10. 1 hit.
InterProⁱ	View protein in InterPro IPR014811. ArgoL1. IPR032472. ArgoL2. IPR032473. Argonaute_Mid_dom. IPR032474. Argonaute_N. IPR003100. PAZ_dom. IPR003165. Piwi. IPR012337. RNaseH-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08699. ArgoL1. 1 hit. PF16488. ArgoL2. 1 hit. PF16487. ArgoMid. 1 hit. PF16486. ArgoN. 1 hit. PF02170. PAZ. 1 hit. PF02171. Piwi. 1 hit.
SMARTⁱ	View protein in SMART SM01163. DUF1785. 1 hit. SM00949. PAZ. 1 hit. SM00950. Piwi. 1 hit.
SUPFAMⁱ	SSF101690. SSF101690. 1 hit. SSF53098. SSF53098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50821. PAZ. 1 hit. PS50822. PIWI. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A4FVC0_HUMAN
Accessionⁱ	A4FVC0Primary (citable) accession number: A4FVC0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 17, 2007
	Last sequence update:	April 17, 2007
	Last modified:	July 5, 2017
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A4FVC0 (A4FVC0_HUMAN)

Your basket is currently empty.

eIF2C2 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ