UniProtKB - A4FVC0 (A4FVC0_HUMAN)
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Protein
Submitted name:
eIF2C2 protein
Gene
EIF2C2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nucleic acid binding Source: InterPro
GO - Biological processi
- gene silencing by RNA Source: UniProtKB-KW
Keywordsi
Biological process | RNA-mediated gene silencingSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: eIF2C2 proteinImported |
Gene namesi | Name:EIF2C2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 184 – 297 | PAZInterPro annotationAdd BLAST | 114 | |
Domaini | 466 – 767 | PiwiInterPro annotationAdd BLAST | 302 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1041 Eukaryota ENOG410XP07 LUCA |
HOVERGENi | HBG006101 |
Family and domain databases
Gene3Di | 3.30.420.101 hit |
InterProi | View protein in InterPro IPR014811 ArgoL1 IPR032472 ArgoL2 IPR032473 Argonaute_Mid_dom IPR032474 Argonaute_N IPR003100 PAZ_dom IPR036085 PAZ_dom_sf IPR003165 Piwi IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf |
Pfami | View protein in Pfam PF08699 ArgoL1, 1 hit PF16488 ArgoL2, 1 hit PF16487 ArgoMid, 1 hit PF16486 ArgoN, 1 hit PF02170 PAZ, 1 hit PF02171 Piwi, 1 hit |
SMARTi | View protein in SMART SM01163 DUF1785, 1 hit SM00949 PAZ, 1 hit SM00950 Piwi, 1 hit |
SUPFAMi | SSF101690 SSF101690, 1 hit SSF53098 SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50821 PAZ, 1 hit PS50822 PIWI, 1 hit |
i Sequence
Sequence statusi: Fragment.
A4FVC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RPPLGPGAPR RRHHVLGSRP REIVEHMVQH FKTQIFGDRK PVFDGRKNLY
60 70 80 90 100
TAMPLPIGRD KVELEVTLPG EGKDRIFKVS IKWVSCVSLQ ALHDALSGRL
110 120 130 140 150
PSVPFETIQA LDVVMRHLPS MRYTPVGRSF FTASEGCSNP LGGGREVWFG
160 170 180 190 200
FHQSVRPSLW KMMLNIDVSA TAFYKAQPVI EFVCEVLDFK SIEEQQKPLT
210 220 230 240 250
DSQRVKFTKE IKGLKVEITH CGQMKRKYRV CNVTRRPASH QTFPLQQESG
260 270 280 290 300
QTVECTVAQY FKDRHKLVLR YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR
310 320 330 340 350
CIKKLTDNQT STMIRATARS APDRQEEISK LMRSASFNTD PYVREFGIMV
360 370 380 390 400
KDEMTDVTGR VLQPPSILYG GRNKAIATPV QGVWDMRNKQ FHTGIEIKVW
410 420 430 440 450
AIACFAPQRQ CTEVHLKSFT EQLRKISRDA GMPIQGQPCF CKYAQGADSV
460 470 480 490 500
EPMFRHLKNT YAGLQLVVVI LPGKTPVYAE VKRVGDTVLG MATQCVQMKN
510 520 530 540 550
VQRTTPQTLS NLCLKINVKL GGVNNILLPQ GRPPVFQQPV IFLGADVTHP
560 570 580 590 600
PAGDGKKPSI AAVVGSMDAH PNRYCATVRV QQHRQEIIQD LAAMVRELLI
610 620 630 640 650
QFYKSTRFKP TRIIFYRDGV SEGQFQQVLH HELLAIREAC IKLEKDYQPG
660 670 680 690 700
ITFIVVQKRH HTRLFCTDKN ERVGKSGNIP AGTTVDTKIT HPTEFDFYLC
710 720 730 740 750
SHAGIQGTSR PSHYHVLWDD NRFSSDELQI LTYQLCHTYV RCTRSVSIPA
760 770 780 790 800
PAYYAHLVAF RARYHLVDKE HDSAEGSHTS GQSNGRDHQA LAKAVQVHQD
TLRTMYFA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC125213 mRNA Translation: AAI25214.1 |
UniGenei | Hs.660189 Hs.743313 |
Similar proteinsi
Entry informationi
Entry namei | A4FVC0_HUMAN | |
Accessioni | A4FVC0Primary (citable) accession number: A4FVC0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 17, 2007 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 28, 2018 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |