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Protein
Submitted name:

EIF2C2 protein

Gene

EIF2C2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EIF2C2 proteinImported
Gene namesi
Name:EIF2C2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27694.

PTM / Processingi

Proteomic databases

PaxDbiA4FVC0.
PeptideAtlasiA4FVC0.
PRIDEiA4FVC0.

Expressioni

Gene expression databases

GenevisibleiA4FVC0. HS.

Interactioni

Protein-protein interaction databases

IntActiA4FVC0. 11 interactors.
STRINGi9606.ENSP00000220592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 297PAZInterPro annotationAdd BLAST114
Domaini466 – 767PiwiInterPro annotationAdd BLAST302

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotation
Contains 1 PAZ domain.UniRule annotation
Contains 1 Piwi domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
HOVERGENiHBG006101.
KOiK11593.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A4FVC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RPPLGPGAPR RRHHVLGSRP REIVEHMVQH FKTQIFGDRK PVFDGRKNLY
60 70 80 90 100
TAMPLPIGRD KVELEVTLPG EGKDRIFKVS IKWVSCVSLQ ALHDALSGRL
110 120 130 140 150
PSVPFETIQA LDVVMRHLPS MRYTPVGRSF FTASEGCSNP LGGGREVWFG
160 170 180 190 200
FHQSVRPSLW KMMLNIDVSA TAFYKAQPVI EFVCEVLDFK SIEEQQKPLT
210 220 230 240 250
DSQRVKFTKE IKGLKVEITH CGQMKRKYRV CNVTRRPASH QTFPLQQESG
260 270 280 290 300
QTVECTVAQY FKDRHKLVLR YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR
310 320 330 340 350
CIKKLTDNQT STMIRATARS APDRQEEISK LMRSASFNTD PYVREFGIMV
360 370 380 390 400
KDEMTDVTGR VLQPPSILYG GRNKAIATPV QGVWDMRNKQ FHTGIEIKVW
410 420 430 440 450
AIACFAPQRQ CTEVHLKSFT EQLRKISRDA GMPIQGQPCF CKYAQGADSV
460 470 480 490 500
EPMFRHLKNT YAGLQLVVVI LPGKTPVYAE VKRVGDTVLG MATQCVQMKN
510 520 530 540 550
VQRTTPQTLS NLCLKINVKL GGVNNILLPQ GRPPVFQQPV IFLGADVTHP
560 570 580 590 600
PAGDGKKPSI AAVVGSMDAH PNRYCATVRV QQHRQEIIQD LAAMVRELLI
610 620 630 640 650
QFYKSTRFKP TRIIFYRDGV SEGQFQQVLH HELLAIREAC IKLEKDYQPG
660 670 680 690 700
ITFIVVQKRH HTRLFCTDKN ERVGKSGNIP AGTTVDTKIT HPTEFDFYLC
710 720 730 740 750
SHAGIQGTSR PSHYHVLWDD NRFSSDELQI LTYQLCHTYV RCTRSVSIPA
760 770 780 790 800
PAYYAHLVAF RARYHLVDKE HDSAEGSHTS GQSNGRDHQA LAKAVQVHQD

TLRTMYFA
Length:808
Mass (Da):91,497
Last modified:April 17, 2007 - v1
Checksum:i7D58FD57997FAC7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125213 mRNA. Translation: AAI25214.1.
RefSeqiNP_001158095.1. NM_001164623.1.
NP_036286.2. NM_012154.3.
UniGeneiHs.743313.

Genome annotation databases

GeneIDi27161.
KEGGihsa:27161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125213 mRNA. Translation: AAI25214.1.
RefSeqiNP_001158095.1. NM_001164623.1.
NP_036286.2. NM_012154.3.
UniGeneiHs.743313.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4FVC0. 11 interactors.
STRINGi9606.ENSP00000220592.

Proteomic databases

PaxDbiA4FVC0.
PeptideAtlasiA4FVC0.
PRIDEiA4FVC0.

Protocols and materials databases

DNASUi27161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27161.
KEGGihsa:27161.

Organism-specific databases

CTDi27161.
PharmGKBiPA27694.

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
HOVERGENiHBG006101.
KOiK11593.

Miscellaneous databases

GenomeRNAii27161.

Gene expression databases

GenevisibleiA4FVC0. HS.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4FVC0_HUMAN
AccessioniPrimary (citable) accession number: A4FVC0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: July 6, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.