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UniProtKB - A4FVC0 (A4FVC0_HUMAN)

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Protein
Submitted name:

eIF2C2 protein

Gene

EIF2C2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Biological processRNA-mediated gene silencingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
eIF2C2 proteinImported
Gene namesi
Name:EIF2C2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27694.

PTM / Processingi

Proteomic databases

PaxDbiA4FVC0.
PeptideAtlasiA4FVC0.
PRIDEiA4FVC0.

Expressioni

Gene expression databases

GenevisibleiA4FVC0. HS.

Interactioni

Protein-protein interaction databases

IntActiA4FVC0. 11 interactors.
STRINGi9606.ENSP00000220592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 297PAZInterPro annotationAdd BLAST114
Domaini466 – 767PiwiInterPro annotationAdd BLAST302

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
HOVERGENiHBG006101.
KOiK11593.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
SMARTiView protein in SMART
SM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.

Sequencei

Sequence statusi: Fragment.

A4FVC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RPPLGPGAPR RRHHVLGSRP REIVEHMVQH FKTQIFGDRK PVFDGRKNLY 
        60         70         80         90        100
TAMPLPIGRD KVELEVTLPG EGKDRIFKVS IKWVSCVSLQ ALHDALSGRL 
       110        120        130        140        150
PSVPFETIQA LDVVMRHLPS MRYTPVGRSF FTASEGCSNP LGGGREVWFG 
       160        170        180        190        200
FHQSVRPSLW KMMLNIDVSA TAFYKAQPVI EFVCEVLDFK SIEEQQKPLT 
       210        220        230        240        250
DSQRVKFTKE IKGLKVEITH CGQMKRKYRV CNVTRRPASH QTFPLQQESG 
       260        270        280        290        300
QTVECTVAQY FKDRHKLVLR YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR 
       310        320        330        340        350
CIKKLTDNQT STMIRATARS APDRQEEISK LMRSASFNTD PYVREFGIMV 
       360        370        380        390        400
KDEMTDVTGR VLQPPSILYG GRNKAIATPV QGVWDMRNKQ FHTGIEIKVW 
       410        420        430        440        450
AIACFAPQRQ CTEVHLKSFT EQLRKISRDA GMPIQGQPCF CKYAQGADSV 
       460        470        480        490        500
EPMFRHLKNT YAGLQLVVVI LPGKTPVYAE VKRVGDTVLG MATQCVQMKN 
       510        520        530        540        550
VQRTTPQTLS NLCLKINVKL GGVNNILLPQ GRPPVFQQPV IFLGADVTHP 
       560        570        580        590        600
PAGDGKKPSI AAVVGSMDAH PNRYCATVRV QQHRQEIIQD LAAMVRELLI 
       610        620        630        640        650
QFYKSTRFKP TRIIFYRDGV SEGQFQQVLH HELLAIREAC IKLEKDYQPG 
       660        670        680        690        700
ITFIVVQKRH HTRLFCTDKN ERVGKSGNIP AGTTVDTKIT HPTEFDFYLC 
       710        720        730        740        750
SHAGIQGTSR PSHYHVLWDD NRFSSDELQI LTYQLCHTYV RCTRSVSIPA 
       760        770        780        790        800
PAYYAHLVAF RARYHLVDKE HDSAEGSHTS GQSNGRDHQA LAKAVQVHQD 

TLRTMYFA
Length:808
Mass (Da):91,497
Last modified:April 17, 2007 - v1
Checksum:i7D58FD57997FAC7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125213 mRNA. Translation: AAI25214.1.
RefSeqiNP_001158095.1. NM_001164623.1.
NP_036286.2. NM_012154.3.
UniGeneiHs.660189.
Hs.743313.

Genome annotation databases

KEGGihsa:27161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125213 mRNA. Translation: AAI25214.1.
RefSeqiNP_001158095.1. NM_001164623.1.
NP_036286.2. NM_012154.3.
UniGeneiHs.660189.
Hs.743313.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4FVC0. 11 interactors.
STRINGi9606.ENSP00000220592.

Proteomic databases

PaxDbiA4FVC0.
PeptideAtlasiA4FVC0.
PRIDEiA4FVC0.

Protocols and materials databases

DNASUi27161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGihsa:27161.

Organism-specific databases

CTDi27161.
PharmGKBiPA27694.

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
HOVERGENiHBG006101.
KOiK11593.

Miscellaneous databases

GenomeRNAii27161.

Gene expression databases

GenevisibleiA4FVC0. HS.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
SMARTiView protein in SMART
SM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4FVC0_HUMAN
AccessioniPrimary (citable) accession number: A4FVC0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 10, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.