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Protein

Zinc finger protein AEBP2

Gene

AEBP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri255 – 280C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri294 – 316C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-212300. PRC2 methylates histones and DNA.
R-BTA-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
Gene namesi
Name:AEBP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003415892 – 511Zinc finger protein AEBP2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4FV57.
PRIDEiA4FV57.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010818.

Interactioni

Subunit structurei

Self-associates (By similarity). Interacts with EED, EZH2, RBBP4 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2 (By similarity). May also interact with RBBP7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034344.

Structurei

3D structure databases

ProteinModelPortaliA4FV57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 288Interaction with RBBP4By similarityAdd BLAST86
Regioni347 – 511Interaction with SUZ12By similarityAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 116Glu-richAdd BLAST83
Compositional biasi60 – 199Gly-richAdd BLAST140
Compositional biasi104 – 250Ser-richAdd BLAST147

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri255 – 280C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri294 – 316C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
InParanoidiA4FV57.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
TreeFamiTF328864.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FV57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALTDMAD LEELSRLSPL PPGSPGPAAR GRAEPPEEEE EEDEEEEAEA
60 70 80 90 100
EAVAALLLNG GGGGGGVGGG EAETMSEPSP ESASQAGEDD DEEEDDDEEE
110 120 130 140 150
EDESSSGGGE EESSAESLVG SSSGGSSSDE TRSLSPGAAS SSSGDGDGKE
160 170 180 190 200
GLEEPKGPRG SQGGGGGGSS SSSVVSSGGD EGYGTGGGGS SATSGGRRGS
210 220 230 240 250
LEMSSDGEPL SRMDSEDSIS STIMDVDSTI SSGRSTPAMM NGQGSTTSSS
260 270 280 290 300
KNIAYNCCWD QCQACFTSSP DLADHIRSIH VDGQRGGVFV CLWKGCKVYN
310 320 330 340 350
TPSTSQSWLQ RHMLTHSGDK PFKCVVGGCN ASFASQGGLA RHVPTHFSQQ
360 370 380 390 400
NSSKVSSQPK AKEESPSKAG MNKRRKLKNK RRRSLPRPHD FFDAQTLDAI
410 420 430 440 450
RHRAICFNLS AHIESLGKGH SVVFHSTVIA KRKEDSGKIK LLLHWMPEDI
460 470 480 490 500
LPDVWVNESE RHQLKTKVVH LSKLPKDTAL LLDPNIYRTM PQKRLKRTLI
510
RKVFNLYLSK Q
Length:511
Mass (Da):54,049
Last modified:June 10, 2008 - v2
Checksum:iDD20C9A5678B946A
GO

Sequence cautioni

The sequence AAI23768 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03004480 Genomic DNA. No translation available.
AAFC03026658 Genomic DNA. No translation available.
BC123767 mRNA. Translation: AAI23768.1. Different initiation.
RefSeqiNP_001076954.2. NM_001083485.2.
UniGeneiBt.14655.

Genome annotation databases

EnsembliENSBTAT00000034452; ENSBTAP00000034344; ENSBTAG00000010818.
GeneIDi537791.
KEGGibta:537791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03004480 Genomic DNA. No translation available.
AAFC03026658 Genomic DNA. No translation available.
BC123767 mRNA. Translation: AAI23768.1. Different initiation.
RefSeqiNP_001076954.2. NM_001083485.2.
UniGeneiBt.14655.

3D structure databases

ProteinModelPortaliA4FV57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034344.

Proteomic databases

PaxDbiA4FV57.
PRIDEiA4FV57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000034452; ENSBTAP00000034344; ENSBTAG00000010818.
GeneIDi537791.
KEGGibta:537791.

Organism-specific databases

CTDi121536.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
InParanoidiA4FV57.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
TreeFamiTF328864.

Enzyme and pathway databases

ReactomeiR-BTA-212300. PRC2 methylates histones and DNA.
R-BTA-3214841. PKMTs methylate histone lysines.

Gene expression databases

BgeeiENSBTAG00000010818.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAEBP2_BOVIN
AccessioniPrimary (citable) accession number: A4FV57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.