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Protein

Vesicular glutamate transporter 1

Gene

SLC17A7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (By similarity).By similarity

GO - Molecular functioni

  1. sodium:inorganic phosphate symporter activity Source: Ensembl

GO - Biological processi

  1. L-glutamate import Source: Ensembl
  2. long-term memory Source: Ensembl
  3. neurotransmitter transport Source: UniProtKB-KW
  4. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  5. sequestering of neurotransmitter Source: Ensembl
  6. synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_280440. Organic anion transporters.
REACT_318824. Glutamate Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 1
Short name:
VGluT1
Alternative name(s):
Solute carrier family 17 member 7
Gene namesi
Name:SLC17A7
Synonyms:VGLUT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 11632ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 1403CytoplasmicSequence Analysis
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 1698ExtracellularSequence Analysis
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 20818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 2367ExtracellularSequence Analysis
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Topological domaini258 – 30245CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Topological domaini324 – 34118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 37816CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Topological domaini400 – 4012ExtracellularSequence Analysis
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Topological domaini423 – 43513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence AnalysisAdd
BLAST
Topological domaini457 – 46913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence AnalysisAdd
BLAST
Topological domaini491 – 56070CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cerebellar mossy fiber Source: Ensembl
  3. excitatory synapse Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. presynaptic active zone Source: Ensembl
  6. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Vesicular glutamate transporter 1PRO_0000331610Add
BLAST

Proteomic databases

PRIDEiA4FV52.

Interactioni

Subunit structurei

Interacts with SHANK3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009255.

Structurei

3D structure databases

ProteinModelPortaliA4FV52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi530 – 55627Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiA4FV52.
KOiK12302.
OMAiPLTKFNT.
OrthoDBiEOG789C9Z.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FV52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP
60 70 80 90 100
VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG
110 120 130 140 150
HVVMQKAQFN WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA
160 170 180 190 200
IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP
210 220 230 240 250
LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL
260 270 280 290 300
FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT
310 320 330 340 350
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV
360 370 380 390 400
MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS
410 420 430 440 450
KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM
460 470 480 490 500
VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP
510 520 530 540 550
EEMSEEKCGF VGHDQLAGSD ESEMEDEAEP PGAPPAPPPS YGATHSTVQP
560
PRPPPPVRDY
Length:560
Mass (Da):61,651
Last modified:April 17, 2007 - v1
Checksum:i11BD484EF2D2045C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123750 mRNA. Translation: AAI23751.1.
RefSeqiNP_001091515.1. NM_001098046.1.
UniGeneiBt.35972.

Genome annotation databases

EnsembliENSBTAT00000009255; ENSBTAP00000009255; ENSBTAG00000007036.
GeneIDi518849.
KEGGibta:518849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123750 mRNA. Translation: AAI23751.1.
RefSeqiNP_001091515.1. NM_001098046.1.
UniGeneiBt.35972.

3D structure databases

ProteinModelPortaliA4FV52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009255.

Proteomic databases

PRIDEiA4FV52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009255; ENSBTAP00000009255; ENSBTAG00000007036.
GeneIDi518849.
KEGGibta:518849.

Organism-specific databases

CTDi57030.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiA4FV52.
KOiK12302.
OMAiPLTKFNT.
OrthoDBiEOG789C9Z.
TreeFamiTF313535.

Enzyme and pathway databases

ReactomeiREACT_280440. Organic anion transporters.
REACT_318824. Glutamate Neurotransmitter Release Cycle.

Miscellaneous databases

NextBioi20872748.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiVGLU1_BOVIN
AccessioniPrimary (citable) accession number: A4FV52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.