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A4FV52

- VGLU1_BOVIN

UniProt

A4FV52 - VGLU1_BOVIN

Protein

Vesicular glutamate transporter 1

Gene

SLC17A7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate By similarity.By similarity

    GO - Molecular functioni

    1. sodium:inorganic phosphate symporter activity Source: Ensembl

    GO - Biological processi

    1. L-glutamate import Source: Ensembl
    2. long-term memory Source: Ensembl
    3. neurotransmitter transport Source: UniProtKB-KW
    4. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    5. sequestering of neurotransmitter Source: Ensembl
    6. synaptic transmission, glutamatergic Source: Ensembl

    Keywords - Biological processi

    Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_212967. Glutamate Neurotransmitter Release Cycle.
    REACT_216261. Organic anion transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicular glutamate transporter 1
    Short name:
    VGluT1
    Alternative name(s):
    Solute carrier family 17 member 7
    Gene namesi
    Name:SLC17A7
    Synonyms:VGLUT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. excitatory synapse Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuron projection Source: UniProtKB-SubCell
    5. presynaptic active zone Source: Ensembl
    6. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Vesicular glutamate transporter 1PRO_0000331610Add
    BLAST

    Proteomic databases

    PRIDEiA4FV52.

    Interactioni

    Subunit structurei

    Interacts with SHANK3.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009255.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FV52.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 11632ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 1403CytoplasmicSequence Analysis
    Topological domaini162 – 1698ExtracellularSequence Analysis
    Topological domaini191 – 20818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 2367ExtracellularSequence Analysis
    Topological domaini258 – 30245CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 34118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini363 – 37816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 4012ExtracellularSequence Analysis
    Topological domaini423 – 43513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini457 – 46913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini491 – 56070CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi530 – 55627Pro-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00630000089608.
    HOGENOMiHOG000230812.
    HOVERGENiHBG008834.
    InParanoidiA4FV52.
    KOiK12302.
    OMAiMHGHVVI.
    OrthoDBiEOG789C9Z.
    TreeFamiTF313535.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FV52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP    50
    VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG 100
    HVVMQKAQFN WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA 150
    IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP 200
    LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL 250
    FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 300
    SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV 350
    MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS 400
    KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM 450
    VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP 500
    EEMSEEKCGF VGHDQLAGSD ESEMEDEAEP PGAPPAPPPS YGATHSTVQP 550
    PRPPPPVRDY 560
    Length:560
    Mass (Da):61,651
    Last modified:April 17, 2007 - v1
    Checksum:i11BD484EF2D2045C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123750 mRNA. Translation: AAI23751.1.
    RefSeqiNP_001091515.1. NM_001098046.1.
    UniGeneiBt.35972.

    Genome annotation databases

    EnsembliENSBTAT00000009255; ENSBTAP00000009255; ENSBTAG00000007036.
    GeneIDi518849.
    KEGGibta:518849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123750 mRNA. Translation: AAI23751.1 .
    RefSeqi NP_001091515.1. NM_001098046.1.
    UniGenei Bt.35972.

    3D structure databases

    ProteinModelPortali A4FV52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009255.

    Proteomic databases

    PRIDEi A4FV52.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009255 ; ENSBTAP00000009255 ; ENSBTAG00000007036 .
    GeneIDi 518849.
    KEGGi bta:518849.

    Organism-specific databases

    CTDi 57030.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00630000089608.
    HOGENOMi HOG000230812.
    HOVERGENi HBG008834.
    InParanoidi A4FV52.
    KOi K12302.
    OMAi MHGHVVI.
    OrthoDBi EOG789C9Z.
    TreeFami TF313535.

    Enzyme and pathway databases

    Reactomei REACT_212967. Glutamate Neurotransmitter Release Cycle.
    REACT_216261. Organic anion transporters.

    Miscellaneous databases

    NextBioi 20872748.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiVGLU1_BOVIN
    AccessioniPrimary (citable) accession number: A4FV52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3