Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4FV52 (VGLU1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicular glutamate transporter 1

Short name=VGluT1
Alternative name(s):
Solute carrier family 17 member 7
Gene names
Name:SLC17A7
Synonyms:VGLUT1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate By similarity.

Subunit structure

Interacts with SHANK3 By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity. Membrane; Multi-pass membrane protein Potential. Cell junctionsynapsesynaptosome By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Vesicular glutamate transporter 1
PRO_0000331610

Regions

Topological domain1 – 6363Cytoplasmic Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 11632Extracellular Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 1403Cytoplasmic Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 1698Extracellular Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 20818Cytoplasmic Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 2367Extracellular Potential
Transmembrane237 – 25721Helical; Potential
Topological domain258 – 30245Cytoplasmic Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 34118Extracellular Potential
Transmembrane342 – 36221Helical; Potential
Topological domain363 – 37816Cytoplasmic Potential
Transmembrane379 – 39921Helical; Potential
Topological domain400 – 4012Extracellular Potential
Transmembrane402 – 42221Helical; Potential
Topological domain423 – 43513Cytoplasmic Potential
Transmembrane436 – 45621Helical; Potential
Topological domain457 – 46913Extracellular Potential
Transmembrane470 – 49021Helical; Potential
Topological domain491 – 56070Cytoplasmic Potential
Compositional bias530 – 55627Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A4FV52 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 11BD484EF2D2045C

FASTA56061,651
        10         20         30         40         50         60 
MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP VVDCTCFGLP 

        70         80         90        100        110        120 
RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVMQKAQFN WDPETVGLIH 

       130        140        150        160        170        180 
GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG 

       190        200        210        220        230        240 
LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV 

       250        260        270        280        290        300 
YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 

       310        320        330        340        350        360 
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ 

       370        380        390        400        410        420 
IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS 

       430        440        450        460        470        480 
GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY 

       490        500        510        520        530        540 
GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD ESEMEDEAEP PGAPPAPPPS 

       550        560 
YGATHSTVQP PRPPPPVRDY 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC123750 mRNA. Translation: AAI23751.1.
RefSeqNP_001091515.1. NM_001098046.1.
UniGeneBt.35972.

3D structure databases

ProteinModelPortalA4FV52.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009255.

Proteomic databases

PRIDEA4FV52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009255; ENSBTAP00000009255; ENSBTAG00000007036.
GeneID518849.
KEGGbta:518849.

Organism-specific databases

CTD57030.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00630000089608.
HOGENOMHOG000230812.
HOVERGENHBG008834.
InParanoidA4FV52.
KOK12302.
OMAMHGHVVI.
OrthoDBEOG789C9Z.
TreeFamTF313535.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20872748.

Entry information

Entry nameVGLU1_BOVIN
AccessionPrimary (citable) accession number: A4FV52
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families