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Protein

Fatty acid desaturase 2

Gene

FADS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and as well other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity).By similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiR-BTA-2046105 Linoleic acid (LA) metabolism
R-BTA-2046106 alpha-linolenic acid (ALA) metabolism
UniPathwayiUPA00658

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid desaturase 2 (EC:1.14.19.-)
Alternative name(s):
Delta(6) fatty acid desaturase
Short name:
D6D
Short name:
Delta(6) desaturase
Short name:
Delta-6 desaturase
Gene namesi
Name:FADS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:28702 FADS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 147LumenalSequence analysis4
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 264CytoplasmicSequence analysisAdd BLAST96
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 305LumenalSequence analysisAdd BLAST20
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 444CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071001 – 444Fatty acid desaturase 2Add BLAST444

Proteomic databases

PaxDbiA4FV48
PRIDEiA4FV48

Expressioni

Gene expression databases

BgeeiENSBTAG00000015505

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020610

Structurei

3D structure databases

ProteinModelPortaliA4FV48
SMRiA4FV48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 95Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi180 – 184Histidine box-15
Motifi217 – 221Histidine box-25
Motifi382 – 386Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4232 Eukaryota
ENOG410XVSZ LUCA
GeneTreeiENSGT00510000046574
HOGENOMiHOG000012997
HOVERGENiHBG002839
InParanoidiA4FV48
KOiK10226
OMAiMESIAWF
OrthoDBiEOG091G0E0W
TreeFamiTF313604

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR005804 FA_desaturase_dom
IPR012171 Fatty_acid_desaturase
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF015921 FA_sphinglp_des, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4FV48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGGNQDEG ATELEAPMPT FRWEEIQKHN LRTDKWLVID RKVYNITKWS
60 70 80 90 100
SRHPGGQRVI GHYAGEDATD AFLAFHRNLD FVRKFMKPLL IGELAPEEPS
110 120 130 140 150
QDRGKNSQIT EDFRALRKTA EDMNLFKSNQ LFFLLHLAHI IAMESIAWFT
160 170 180 190 200
LFYFGNGWIP TIITAFVLAT SQAQAGWLQH DYGHLSVYKK SMWNHIVHKF
210 220 230 240 250
VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV LGEWQPIEYG
260 270 280 290 300
KKKLKYLPYN HQHEYFFLIG PPLLIPLYFQ YQIIMTMIVR KYWADLAWAI
310 320 330 340 350
SYYTRFFITY IPFYGVLGSI LFLNFIRFLE SHWFVWVTQM NHIVMEIDRE
360 370 380 390 400
PYRDWFSSQL AATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA
410 420 430 440
PLVRSLCAKH GIEYQEKPLL RALQDIIGSL RKSGQLWLDA YLHK
Length:444
Mass (Da):52,533
Last modified:April 17, 2007 - v1
Checksum:i6D0C887C1365D4C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123735 mRNA Translation: AAI23736.1
RefSeqiNP_001076913.1, NM_001083444.1
UniGeneiBt.3891

Genome annotation databases

EnsembliENSBTAT00000020610; ENSBTAP00000020610; ENSBTAG00000015505
GeneIDi521822
KEGGibta:521822

Similar proteinsi

Entry informationi

Entry nameiFADS2_BOVIN
AccessioniPrimary (citable) accession number: A4FV48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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