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Protein

Protein kinase C delta-binding protein

Gene

PRKCDBP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C delta-binding protein
Alternative name(s):
Cavin-3
Gene namesi
Name:PRKCDBP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314111 – 260Protein kinase C delta-binding proteinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei162PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei171PhosphoserineBy similarity1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA4FV37.
PeptideAtlasiA4FV37.
PRIDEiA4FV37.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019754.

Interactioni

Subunit structurei

Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026323.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiA4FV37.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FV37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALESGP VPGAPAGGPV HAVTVVTLLE KLATMLETLR ERQGGLAQRQ
60 70 80 90 100
GGLAGSVRRI QSNLGALSRS HDTTSNTLAQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE AEIPAKAFQK APEPLGPVEL
160 170 180 190 200
GPQLPEAEAE ESSDEEEPVE SRARRLRRTG LEKVQSLRRA LSGRKGHAAP
210 220 230 240 250
TPTPVKPPRL GPGRSAEGQW EAQPALESKL EPEPPQDTEE DPGRPGAAEA
260
AAVLQVESAA
Length:260
Mass (Da):27,487
Last modified:April 17, 2007 - v1
Checksum:i5F8C4AB4636A39AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123692 mRNA. Translation: AAI23693.1.
RefSeqiNP_001076870.1. NM_001083401.1.
UniGeneiBt.2285.

Genome annotation databases

EnsembliENSBTAT00000026323; ENSBTAP00000026323; ENSBTAG00000019754.
GeneIDi510203.
KEGGibta:510203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123692 mRNA. Translation: AAI23693.1.
RefSeqiNP_001076870.1. NM_001083401.1.
UniGeneiBt.2285.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026323.

Proteomic databases

PaxDbiA4FV37.
PeptideAtlasiA4FV37.
PRIDEiA4FV37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026323; ENSBTAP00000026323; ENSBTAG00000019754.
GeneIDi510203.
KEGGibta:510203.

Organism-specific databases

CTDi112464.

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiA4FV37.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
TreeFamiTF331031.

Gene expression databases

BgeeiENSBTAG00000019754.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRDBP_BOVIN
AccessioniPrimary (citable) accession number: A4FV37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.