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Protein

Caveolae-associated protein 3

Gene

CAVIN3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 3
Alternative name(s):
Cavin-3
Protein kinase C delta-binding protein
Gene namesi
Name:CAVIN3
Synonyms:PRKCDBP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314111 – 260Caveolae-associated protein 3Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei162PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei171PhosphoserineBy similarity1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA4FV37.
PeptideAtlasiA4FV37.
PRIDEiA4FV37.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019754.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 and EPS15L1. Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026323.

Structurei

3D structure databases

SMRiA4FV37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Interaction with CAVIN1By similarityAdd BLAST84
Regioni20 – 78Leucine-zipperBy similarityAdd BLAST59
Regioni135 – 201Interaction with CAV1By similarityAdd BLAST67

Domaini

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.By similarity

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiA4FV37.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR033300. CAVIN3.
IPR026752. Cavin_fam.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FV37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALESGP VPGAPAGGPV HAVTVVTLLE KLATMLETLR ERQGGLAQRQ
60 70 80 90 100
GGLAGSVRRI QSNLGALSRS HDTTSNTLAQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE AEIPAKAFQK APEPLGPVEL
160 170 180 190 200
GPQLPEAEAE ESSDEEEPVE SRARRLRRTG LEKVQSLRRA LSGRKGHAAP
210 220 230 240 250
TPTPVKPPRL GPGRSAEGQW EAQPALESKL EPEPPQDTEE DPGRPGAAEA
260
AAVLQVESAA
Length:260
Mass (Da):27,487
Last modified:April 17, 2007 - v1
Checksum:i5F8C4AB4636A39AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123692 mRNA. Translation: AAI23693.1.
RefSeqiNP_001076870.1. NM_001083401.1.
UniGeneiBt.2285.

Genome annotation databases

EnsembliENSBTAT00000026323; ENSBTAP00000026323; ENSBTAG00000019754.
GeneIDi510203.
KEGGibta:510203.

Similar proteinsi

Entry informationi

Entry nameiCAVN3_BOVIN
AccessioniPrimary (citable) accession number: A4FV37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families