ID   LAMP5_BOVIN             Reviewed;         280 AA.
AC   A4FV27;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 85.
DE   RecName: Full=Lysosome-associated membrane glycoprotein 5;
DE   AltName: Full=Lysosome-associated membrane protein 5;
DE            Short=LAMP-5;
DE   Flags: Precursor;
GN   Name=LAMP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in short-term synaptic plasticity in a subset of
CC       GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q9D387}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Cell
CC       projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Recycling
CC       endosome {ECO:0000250|UniProtKB:Q9D387}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UJQ1};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I
CC       membrane protein {ECO:0000250|UniProtKB:Q9D387}. Note=Recycles from the
CC       vesicles of the endocytic recycling compartment (ERC) to the plasma
CC       membrane (By similarity). Colocalizes with UNC93B1 in large endosomal
CC       intracellular vesicles (By similarity). Accumulates in the endoplasmic
CC       reticulum-Golgi intermediate compartment (ERGIC) before its
CC       disappearance upon activation by CpG dinucleotides (By similarity).
CC       Associates with cortical membranes (By similarity). Localizes mostly in
CC       cytoplasmic vesicles of neuronal cell body. Localizes to synaptic
CC       vesicles in a subset of GABAergic neurons (By similarity).
CC       {ECO:0000250|UniProtKB:Q9D387, ECO:0000250|UniProtKB:Q9UJQ1}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000305}.
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DR   EMBL; BC123658; AAI23659.1; -; mRNA.
DR   RefSeq; NP_001076887.1; NM_001083418.1.
DR   RefSeq; XP_010809319.1; XM_010811017.1.
DR   AlphaFoldDB; A4FV27; -.
DR   SMR; A4FV27; -.
DR   STRING; 9913.ENSBTAP00000010487; -.
DR   GlyCosmos; A4FV27; 2 sites, No reported glycans.
DR   PaxDb; 9913-ENSBTAP00000010487; -.
DR   Ensembl; ENSBTAT00000010487.4; ENSBTAP00000010487.3; ENSBTAG00000007977.4.
DR   GeneID; 513094; -.
DR   KEGG; bta:513094; -.
DR   CTD; 24141; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007977; -.
DR   VGNC; VGNC:30778; LAMP5.
DR   eggNOG; KOG4818; Eukaryota.
DR   GeneTree; ENSGT00950000182899; -.
DR   HOGENOM; CLU_090529_0_0_1; -.
DR   InParanoid; A4FV27; -.
DR   OMA; HTVTRIM; -.
DR   OrthoDB; 5354428at2759; -.
DR   TreeFam; TF330776; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000007977; Expressed in occipital lobe and 32 other cell types or tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR   GO; GO:0032584; C:growth cone membrane; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR048528; Lamp2-like_luminal.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN; 1.
DR   PANTHER; PTHR11506:SF35; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5; 1.
DR   Pfam; PF01299; Lamp; 1.
DR   PROSITE; PS00310; LAMP_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasmic vesicle; Endosome;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..280
FT                   /note="Lysosome-associated membrane glycoprotein 5"
FT                   /id="PRO_0000360413"
FT   TOPO_DOM        30..235
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   280 AA;  31528 MW;  F23BBEC3E6A5B3A6 CRC64;
     MDLRRRALLG VDGLRVLLML FHTVTRIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA
     EFAAKFIVPY DVWASNYVDL ITEQADISLT RGAEVKGHCG HDESELQVFW VDRAYALKML
     FLKESHNTPK GPEATWKLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY
     ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI
     LGLILGLVIV VTLVIYHIHH KMTANQVQIP RDRSQYKHMG
//