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A4FV27

- LAMP5_BOVIN

UniProt

A4FV27 - LAMP5_BOVIN

Protein

Lysosome-associated membrane glycoprotein 5

Gene

LAMP5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 5
    Alternative name(s):
    Lysosome-associated membrane protein 5
    Short name:
    LAMP-5
    Gene namesi
    Name:LAMP5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Endosome membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane By similarity; Single-pass type I membrane protein By similarity. Recycling endosome By similarity
    Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB
    2. dendrite Source: UniProtKB-SubCell
    3. dendrite membrane Source: UniProtKB
    4. early endosome membrane Source: UniProtKB
    5. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
    6. endosome membrane Source: UniProtKB
    7. growth cone membrane Source: UniProtKB
    8. integral component of membrane Source: UniProtKB-KW
    9. plasma membrane Source: UniProtKB
    10. recycling endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000360413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA4FV27.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAMP family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41798.
    GeneTreeiENSGT00390000012584.
    HOGENOMiHOG000231912.
    HOVERGENiHBG051186.
    InParanoidiA4FV27.
    OMAiCPVDERE.
    OrthoDBiEOG7DRJ3S.
    TreeFamiTF330776.

    Family and domain databases

    InterProiIPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PROSITEiPS00310. LAMP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4FV27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLRRRALLG VDGLRVLLML FHTVTRIMAE QEVENLSGLS TNPEKDIFVV    50
    RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQADISLT RGAEVKGHCG 100
    HDESELQVFW VDRAYALKML FLKESHNTPK GPEATWKLSK VQFVYDSSEK 150
    THFKDAVSAG KHTANSHHLS ALVTPAGKSY ECQAQQTISL ASSDPQKTVT 200
    MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIV 250
    VTLVIYHIHH KMTANQVQIP RDRSQYKHMG 280
    Length:280
    Mass (Da):31,528
    Last modified:April 17, 2007 - v1
    Checksum:iF23BBEC3E6A5B3A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123658 mRNA. Translation: AAI23659.1.
    RefSeqiNP_001076887.1. NM_001083418.1.
    UniGeneiBt.13129.

    Genome annotation databases

    EnsembliENSBTAT00000010487; ENSBTAP00000010487; ENSBTAG00000007977.
    GeneIDi513094.
    KEGGibta:513094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123658 mRNA. Translation: AAI23659.1 .
    RefSeqi NP_001076887.1. NM_001083418.1.
    UniGenei Bt.13129.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A4FV27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010487 ; ENSBTAP00000010487 ; ENSBTAG00000007977 .
    GeneIDi 513094.
    KEGGi bta:513094.

    Organism-specific databases

    CTDi 24141.

    Phylogenomic databases

    eggNOGi NOG41798.
    GeneTreei ENSGT00390000012584.
    HOGENOMi HOG000231912.
    HOVERGENi HBG051186.
    InParanoidi A4FV27.
    OMAi CPVDERE.
    OrthoDBi EOG7DRJ3S.
    TreeFami TF330776.

    Miscellaneous databases

    NextBioi 20870698.

    Family and domain databases

    InterProi IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PROSITEi PS00310. LAMP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiLAMP5_BOVIN
    AccessioniPrimary (citable) accession number: A4FV27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3