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A4FV27 (LAMP5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Lysosome-associated membrane protein 5
Short name=LAMP-5
Gene names
Name:LAMP5
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane; Single-pass type I membrane protein By similarity. Recycling endosome By similarity. Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity.

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 280251Lysosome-associated membrane glycoprotein 5
PRO_0000360413

Regions

Topological domain30 – 235206Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 28024Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A4FV27 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: F23BBEC3E6A5B3A6

FASTA28031,528
        10         20         30         40         50         60 
MDLRRRALLG VDGLRVLLML FHTVTRIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 

        70         80         90        100        110        120 
EFAAKFIVPY DVWASNYVDL ITEQADISLT RGAEVKGHCG HDESELQVFW VDRAYALKML 

       130        140        150        160        170        180 
FLKESHNTPK GPEATWKLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 

       190        200        210        220        230        240 
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 

       250        260        270        280 
LGLILGLVIV VTLVIYHIHH KMTANQVQIP RDRSQYKHMG 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC123658 mRNA. Translation: AAI23659.1.
RefSeqNP_001076887.1. NM_001083418.1.
UniGeneBt.13129.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA4FV27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000010487; ENSBTAP00000010487; ENSBTAG00000007977.
GeneID513094.
KEGGbta:513094.

Organism-specific databases

CTD24141.

Phylogenomic databases

eggNOGNOG41798.
GeneTreeENSGT00390000012584.
HOGENOMHOG000231912.
HOVERGENHBG051186.
InParanoidA4FV27.
OMACPVDERE.
OrthoDBEOG7DRJ3S.
TreeFamTF330776.

Family and domain databases

InterProIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870698.

Entry information

Entry nameLAMP5_BOVIN
AccessionPrimary (citable) accession number: A4FV27
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families