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Protein

Lysosome-associated membrane glycoprotein 5

Gene

LAMP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:LAMP5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:30778 LAMP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 235ExtracellularSequence analysisAdd BLAST206
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 280CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000036041330 – 280Lysosome-associated membrane glycoprotein 5Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA4FV27
PRIDEiA4FV27

Expressioni

Gene expression databases

BgeeiENSBTAG00000007977

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010487

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1D Eukaryota
ENOG410YUG5 LUCA
GeneTreeiENSGT00390000012584
HOGENOMiHOG000231912
HOVERGENiHBG051186
InParanoidiA4FV27
OMAiIYHIHHK
OrthoDBiEOG091G0O9R
TreeFamiTF330776

Family and domain databases

InterProiView protein in InterPro
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PROSITEiView protein in PROSITE
PS00310 LAMP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FV27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRRRALLG VDGLRVLLML FHTVTRIMAE QEVENLSGLS TNPEKDIFVV
60 70 80 90 100
RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQADISLT RGAEVKGHCG
110 120 130 140 150
HDESELQVFW VDRAYALKML FLKESHNTPK GPEATWKLSK VQFVYDSSEK
160 170 180 190 200
THFKDAVSAG KHTANSHHLS ALVTPAGKSY ECQAQQTISL ASSDPQKTVT
210 220 230 240 250
MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIV
260 270 280
VTLVIYHIHH KMTANQVQIP RDRSQYKHMG
Length:280
Mass (Da):31,528
Last modified:April 17, 2007 - v1
Checksum:iF23BBEC3E6A5B3A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123658 mRNA Translation: AAI23659.1
RefSeqiNP_001076887.1, NM_001083418.1
XP_010809319.1, XM_010811017.1
UniGeneiBt.13129

Genome annotation databases

EnsembliENSBTAT00000010487; ENSBTAP00000010487; ENSBTAG00000007977
GeneIDi513094
KEGGibta:513094

Similar proteinsi

Entry informationi

Entry nameiLAMP5_BOVIN
AccessioniPrimary (citable) accession number: A4FV27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome