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A4FV27

- LAMP5_BOVIN

UniProt

A4FV27 - LAMP5_BOVIN

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Protein

Lysosome-associated membrane glycoprotein 5

Gene

LAMP5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:LAMP5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 13

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Endosome membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane By similarity; Single-pass type I membrane protein By similarity. Recycling endosome By similarity
Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB
  2. dendrite membrane Source: UniProtKB
  3. early endosome membrane Source: UniProtKB
  4. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  5. endosome membrane Source: UniProtKB
  6. growth cone membrane Source: UniProtKB
  7. integral component of membrane Source: UniProtKB-KW
  8. plasma membrane Source: UniProtKB
  9. recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000360413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA4FV27.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
BLAST
Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiA4FV27.
OMAiCPVDERE.
OrthoDBiEOG7DRJ3S.
TreeFamiTF330776.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FV27 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLRRRALLG VDGLRVLLML FHTVTRIMAE QEVENLSGLS TNPEKDIFVV
60 70 80 90 100
RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQADISLT RGAEVKGHCG
110 120 130 140 150
HDESELQVFW VDRAYALKML FLKESHNTPK GPEATWKLSK VQFVYDSSEK
160 170 180 190 200
THFKDAVSAG KHTANSHHLS ALVTPAGKSY ECQAQQTISL ASSDPQKTVT
210 220 230 240 250
MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIV
260 270 280
VTLVIYHIHH KMTANQVQIP RDRSQYKHMG
Length:280
Mass (Da):31,528
Last modified:April 17, 2007 - v1
Checksum:iF23BBEC3E6A5B3A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123658 mRNA. Translation: AAI23659.1.
RefSeqiNP_001076887.1. NM_001083418.1.
UniGeneiBt.13129.

Genome annotation databases

EnsembliENSBTAT00000010487; ENSBTAP00000010487; ENSBTAG00000007977.
GeneIDi513094.
KEGGibta:513094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123658 mRNA. Translation: AAI23659.1 .
RefSeqi NP_001076887.1. NM_001083418.1.
UniGenei Bt.13129.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A4FV27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000010487 ; ENSBTAP00000010487 ; ENSBTAG00000007977 .
GeneIDi 513094.
KEGGi bta:513094.

Organism-specific databases

CTDi 24141.

Phylogenomic databases

eggNOGi NOG41798.
GeneTreei ENSGT00390000012584.
HOGENOMi HOG000231912.
HOVERGENi HBG051186.
InParanoidi A4FV27.
OMAi CPVDERE.
OrthoDBi EOG7DRJ3S.
TreeFami TF330776.

Miscellaneous databases

NextBioi 20870698.

Family and domain databases

InterProi IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PROSITEi PS00310. LAMP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiLAMP5_BOVIN
AccessioniPrimary (citable) accession number: A4FV27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3