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Protein

Keratin, type II cuticular Hb3

Gene

KRT83

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb3By similarity
Alternative name(s):
Keratin-83By similarity
Short name:
K83
Type II hair keratin Hb3
Type-II keratin Kb23
Gene namesi
Name:KRT83Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616911 – 493Keratin, type II cuticular Hb3Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiA4FUZ0.
PeptideAtlasiA4FUZ0.
PRIDEiA4FUZ0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008857.

Structurei

3D structure databases

ProteinModelPortaliA4FUZ0.
SMRiA4FUZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 111HeadSequence analysisAdd BLAST111
Regioni112 – 418RodSequence analysisAdd BLAST307
Regioni112 – 146Coil 1ASequence analysisAdd BLAST35
Regioni147 – 156Linker 1Sequence analysis10
Regioni157 – 257Coil 1BSequence analysisAdd BLAST101
Regioni258 – 274Linker 12Sequence analysisAdd BLAST17
Regioni275 – 418Coil 2Sequence analysisAdd BLAST144
Regioni419 – 493TailSequence analysisAdd BLAST75

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA4FUZ0.
KOiK07605.
OMAiCGFSTVG.
OrthoDBiEOG091G06FG.
TreeFamiTF317854.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FUZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGFSTVGS GFGSRAFSCV SACGPRPGRC CITAAPYRGI SCYRGLTGGF
60 70 80 90 100
GSRSVCGGFR AGYCSRSFGY RSGGVGGLSP PCITTVSVNE SLLTPLNLEI
110 120 130 140 150
DPNAQCVKQE EKEQIKCLNN RFAAFIDKVR FLEQQNKLLE TKLQFYQNRQ
160 170 180 190 200
CCESNLEPLF EGYIETLRRE AECVEADSGR LSSELNHVQE VLEGYKKKYE
210 220 230 240 250
EEVALRATAE NEFVALKKDV DCAYIRKSDL EANSEALIQE IDFLRRLYEE
260 270 280 290 300
EIRVLQANIS DTSVIVKMDN SRGLNMDNIV AEIKAQYDDI ASRSRAEAES
310 320 330 340 350
WYRSKCEEIK ATVIRHGETL RRTKEEINEL NRLIQRLTAE VENAKCQNSK
360 370 380 390 400
LEAAVTQAEQ QGEVALNDAR CKLAGLEEAL QKAKQDMACL LKEYQEVMNS
410 420 430 440 450
KLGLDIEIAT YRRLLEGEEQ RLCEGVGAVN VCVSSSRGGV VCGDLCVSGS
460 470 480 490
RPVTGSVCSA PCSGNLAVST GLCAPCGQLN TTCGGGSCSL GRC
Length:493
Mass (Da):53,989
Last modified:April 17, 2007 - v1
Checksum:i0141DC2C56E30F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123471 mRNA. Translation: AAI23472.1.
RefSeqiNP_001076854.1. NM_001083385.1.
UniGeneiBt.56856.

Genome annotation databases

EnsembliENSBTAT00000008857; ENSBTAP00000008857; ENSBTAG00000007144.
GeneIDi507421.
KEGGibta:507421.

Similar proteinsi

Entry informationi

Entry nameiKRT83_BOVIN
AccessioniPrimary (citable) accession number: A4FUZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 17, 2007
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families