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Protein

Keratin, type II cuticular Hb3

Gene

KRT83

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb3By similarity
Alternative name(s):
Keratin-83By similarity
Short name:
K83
Type II hair keratin Hb3
Type-II keratin Kb23
Gene namesi
Name:KRT83Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Keratin, type II cuticular Hb3PRO_0000361691Add
BLAST

Proteomic databases

PaxDbiA4FUZ0.
PeptideAtlasiA4FUZ0.
PRIDEiA4FUZ0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008857.

Structurei

3D structure databases

ProteinModelPortaliA4FUZ0.
SMRiA4FUZ0. Positions 110-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 111111HeadSequence analysisAdd
BLAST
Regioni112 – 418307RodSequence analysisAdd
BLAST
Regioni112 – 14635Coil 1ASequence analysisAdd
BLAST
Regioni147 – 15610Linker 1Sequence analysis
Regioni157 – 257101Coil 1BSequence analysisAdd
BLAST
Regioni258 – 27417Linker 12Sequence analysisAdd
BLAST
Regioni275 – 418144Coil 2Sequence analysisAdd
BLAST
Regioni419 – 49375TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA4FUZ0.
KOiK07605.
OMAiFSTVGCG.
OrthoDBiEOG7B05CW.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FUZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGFSTVGS GFGSRAFSCV SACGPRPGRC CITAAPYRGI SCYRGLTGGF
60 70 80 90 100
GSRSVCGGFR AGYCSRSFGY RSGGVGGLSP PCITTVSVNE SLLTPLNLEI
110 120 130 140 150
DPNAQCVKQE EKEQIKCLNN RFAAFIDKVR FLEQQNKLLE TKLQFYQNRQ
160 170 180 190 200
CCESNLEPLF EGYIETLRRE AECVEADSGR LSSELNHVQE VLEGYKKKYE
210 220 230 240 250
EEVALRATAE NEFVALKKDV DCAYIRKSDL EANSEALIQE IDFLRRLYEE
260 270 280 290 300
EIRVLQANIS DTSVIVKMDN SRGLNMDNIV AEIKAQYDDI ASRSRAEAES
310 320 330 340 350
WYRSKCEEIK ATVIRHGETL RRTKEEINEL NRLIQRLTAE VENAKCQNSK
360 370 380 390 400
LEAAVTQAEQ QGEVALNDAR CKLAGLEEAL QKAKQDMACL LKEYQEVMNS
410 420 430 440 450
KLGLDIEIAT YRRLLEGEEQ RLCEGVGAVN VCVSSSRGGV VCGDLCVSGS
460 470 480 490
RPVTGSVCSA PCSGNLAVST GLCAPCGQLN TTCGGGSCSL GRC
Length:493
Mass (Da):53,989
Last modified:April 17, 2007 - v1
Checksum:i0141DC2C56E30F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123471 mRNA. Translation: AAI23472.1.
RefSeqiNP_001076854.1. NM_001083385.1.
UniGeneiBt.56856.

Genome annotation databases

EnsembliENSBTAT00000008857; ENSBTAP00000008857; ENSBTAG00000007144.
GeneIDi507421.
KEGGibta:507421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123471 mRNA. Translation: AAI23472.1.
RefSeqiNP_001076854.1. NM_001083385.1.
UniGeneiBt.56856.

3D structure databases

ProteinModelPortaliA4FUZ0.
SMRiA4FUZ0. Positions 110-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008857.

Proteomic databases

PaxDbiA4FUZ0.
PeptideAtlasiA4FUZ0.
PRIDEiA4FUZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008857; ENSBTAP00000008857; ENSBTAG00000007144.
GeneIDi507421.
KEGGibta:507421.

Organism-specific databases

CTDi3889.

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA4FUZ0.
KOiK07605.
OMAiFSTVGCG.
OrthoDBiEOG7B05CW.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: Fetal skinImported.

Entry informationi

Entry nameiKRT83_BOVIN
AccessioniPrimary (citable) accession number: A4FUZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 17, 2007
Last modified: July 6, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.