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A4FUW1

- A4FUW1_MOUSE

UniProt

A4FUW1 - A4FUW1_MOUSE

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Protein
Submitted name:

4932417H02Rik protein

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
  2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
  3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl

GO - Biological processi

  1. cell growth Source: Ensembl
  2. cellular response to amino acid stimulus Source: Ensembl
  3. cellular response to nutrient levels Source: Ensembl
  4. positive regulation of endothelial cell proliferation Source: Ensembl
  5. positive regulation of protein serine/threonine kinase activity Source: Ensembl
  6. positive regulation of TOR signaling Source: Ensembl
  7. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
  8. regulation of cell size Source: Ensembl
  9. TOR signaling Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
4932417H02Rik proteinImported
Gene namesi
Name:RptorImported
Synonyms:4932417H02RikImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. lysosomal membrane Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. TORC1 complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA4FUW1.

Expressioni

Gene expression databases

BgeeiA4FUW1.
ExpressionAtlasiA4FUW1. baseline and differential.
GenevestigatoriA4FUW1.

Structurei

3D structure databases

ProteinModelPortaliA4FUW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

HOVERGENiHBG059496.
KOiK07204.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A4FUW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SEMLQSPLMG LGEEDEADLT DWNLPLAFMK KRHCEKIEGS KSLAQSWRMK
60 70 80 90 100
DRMKTVSVAL VLCLNVGVDP PDVVKTTPCA RLECWIDPLS MGPQKALETI
110 120 130 140 150
GANLQKQYEN WQPRARYKQS LDPTVDEVKK LCTSLRRNAK EERVLFHYNG
160 170 180 190 200
HGVPRPTVNG EVWVFNKNYT QYIPLSIYDL QTWMGSPSIF VYDCSNAGLI
210 220 230 240 250
VKSFKQFALQ REQELEVAAI NPNHPLAQMP LPPSMKNCIQ LAACEAHELL
260 270 280 290 300
PMIPDLPADL FTSCLTTPIK IALRWFCMQK CVSLVPGVTL DLIEKIPGRL
310 320 330 340 350
NDRRTPLGEL NWIFTAITDT IAWNVLPRDL FQKLFRQDLL VASLFRNFLL
360 370 380 390 400
AERIMRSYNC TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ LPTIIEEGTA
410 420 430 440 450
FRHSPFFAEQ LTAFQVWLTM GVENRSPPEQ LPIVLQVLLS QVHRLRALDL
460 470 480 490 500
LGRFLDLGPW AVSLALSVGI FPYVLKLLQS SARELRPLLV FIWAKILAVD
510 520 530 540 550
SSCQADLVKD NGHKYFLSVL ADPYMPAEHR TMTAFILAVI VNSYTTGQEA
560 570 580 590 600
CLQGNLIAIC LEQLSDPHPL LRQWVAICLG RIWQNFDSAR WCGVRDSAHE
610 620 630 640 650
KLYSLLSDPI PEVRCAAVFA LGTFVGNSAE RTDHSTTIDH NVAMMLAQLI
660 670 680 690 700
NDGSPMVRKE LVVALSHLVV QYESNFCTVA LQFMEEEKNY PLPSPAATEG
710 720 730 740 750
GSLTPVRDSP CTPRLRSVSS YGNIRAVTTA RNLNKSLQNL SLTEESGSSV
760 770 780 790 800
AFSPGNLSTS SSASSTLGSP ENEEYILSFE TIDKMRRVSS YSALNSLIGV
810 820 830 840 850
SFNSVYTQIW RVLLHLAADP YPDVSDLAMK VLNSIAYKAT VNARPQRILD
860 870 880 890 900
TSSLTQSAPA SPTNKGMHMH QVGGSPPASS TSSCSLTNDV AKQTVSRDLP
910 920 930 940 950
SSRPGTAGPT GAQYTPHSHQ FPRTRKMFDK GPDQTTDDAD DAAGHKSFIC
960 970 980 990 1000
ASMQTGFCDW SARYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA
1010 1020 1030 1040 1050
QQVIQKGITR LDDQIFLNRN PGVPSVVKFH PFTPCIAVAD KDSICFWDWE
1060 1070 1080 1090 1100
KGEKLDYFHN GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL
1110 1120 1130 1140 1150
EKNPEMVTAW QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT
1160 1170 1180 1190 1200
DRETKVQDIP TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC
1210 1220 1230 1240 1250
RVMTYREHTA WVVKAYLQKH PEGHIVSVSV NGDVRFFDPR MPESVNVMQI
1260 1270 1280 1290 1300
VKGLTALDIH PQANLIACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG
1310 1320 1330
AISCLAFHPH WPHLAVGSND YYISVYSVEK RVR
Length:1,333
Mass (Da):149,237
Last modified:April 17, 2007 - v1
Checksum:i60A3334526AB9085
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118971 mRNA. Translation: AAI18972.1.
RefSeqiNP_083174.2. NM_028898.2.
UniGeneiMm.209933.

Genome annotation databases

GeneIDi74370.
KEGGimmu:74370.
UCSCiuc011yit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118971 mRNA. Translation: AAI18972.1 .
RefSeqi NP_083174.2. NM_028898.2.
UniGenei Mm.209933.

3D structure databases

ProteinModelPortali A4FUW1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A4FUW1.

Protocols and materials databases

DNASUi 74370.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 74370.
KEGGi mmu:74370.
UCSCi uc011yit.1. mouse.

Organism-specific databases

CTDi 57521.
MGIi MGI:1921620. Rptor.

Phylogenomic databases

HOVERGENi HBG059496.
KOi K07204.

Enzyme and pathway databases

Reactomei REACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Miscellaneous databases

ChiTaRSi Rptor. mouse.
NextBioi 340575.
SOURCEi Search...

Gene expression databases

Bgeei A4FUW1.
ExpressionAtlasi A4FUW1. baseline and differential.
Genevestigatori A4FUW1.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR12848. PTHR12848. 1 hit.
Pfami PF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA4FUW1_MOUSE
AccessioniPrimary (citable) accession number: A4FUW1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)