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A4FUW1

- A4FUW1_MOUSE

UniProt

A4FUW1 - A4FUW1_MOUSE

Protein
Submitted name:

4932417H02Rik protein

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
    2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
    3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl

    GO - Biological processi

    1. cell growth Source: Ensembl
    2. cellular response to amino acid stimulus Source: Ensembl
    3. cellular response to nutrient levels Source: Ensembl
    4. positive regulation of endothelial cell proliferation Source: Ensembl
    5. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    6. positive regulation of TOR signaling Source: Ensembl
    7. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
    8. regulation of cell size Source: Ensembl
    9. TOR signaling Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    4932417H02Rik proteinImported
    Gene namesi
    Name:RptorImported
    Synonyms:4932417H02RikImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1921620. Rptor.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. TORC1 complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiA4FUW1.

    Expressioni

    Gene expression databases

    BgeeiA4FUW1.
    GenevestigatoriA4FUW1.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FUW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation, WD repeatUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG059496.
    InParanoidiA4FUW1.
    KOiK07204.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR12848. PTHR12848. 1 hit.
    PfamiPF14538. Raptor_N. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A4FUW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    SEMLQSPLMG LGEEDEADLT DWNLPLAFMK KRHCEKIEGS KSLAQSWRMK     50
    DRMKTVSVAL VLCLNVGVDP PDVVKTTPCA RLECWIDPLS MGPQKALETI 100
    GANLQKQYEN WQPRARYKQS LDPTVDEVKK LCTSLRRNAK EERVLFHYNG 150
    HGVPRPTVNG EVWVFNKNYT QYIPLSIYDL QTWMGSPSIF VYDCSNAGLI 200
    VKSFKQFALQ REQELEVAAI NPNHPLAQMP LPPSMKNCIQ LAACEAHELL 250
    PMIPDLPADL FTSCLTTPIK IALRWFCMQK CVSLVPGVTL DLIEKIPGRL 300
    NDRRTPLGEL NWIFTAITDT IAWNVLPRDL FQKLFRQDLL VASLFRNFLL 350
    AERIMRSYNC TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ LPTIIEEGTA 400
    FRHSPFFAEQ LTAFQVWLTM GVENRSPPEQ LPIVLQVLLS QVHRLRALDL 450
    LGRFLDLGPW AVSLALSVGI FPYVLKLLQS SARELRPLLV FIWAKILAVD 500
    SSCQADLVKD NGHKYFLSVL ADPYMPAEHR TMTAFILAVI VNSYTTGQEA 550
    CLQGNLIAIC LEQLSDPHPL LRQWVAICLG RIWQNFDSAR WCGVRDSAHE 600
    KLYSLLSDPI PEVRCAAVFA LGTFVGNSAE RTDHSTTIDH NVAMMLAQLI 650
    NDGSPMVRKE LVVALSHLVV QYESNFCTVA LQFMEEEKNY PLPSPAATEG 700
    GSLTPVRDSP CTPRLRSVSS YGNIRAVTTA RNLNKSLQNL SLTEESGSSV 750
    AFSPGNLSTS SSASSTLGSP ENEEYILSFE TIDKMRRVSS YSALNSLIGV 800
    SFNSVYTQIW RVLLHLAADP YPDVSDLAMK VLNSIAYKAT VNARPQRILD 850
    TSSLTQSAPA SPTNKGMHMH QVGGSPPASS TSSCSLTNDV AKQTVSRDLP 900
    SSRPGTAGPT GAQYTPHSHQ FPRTRKMFDK GPDQTTDDAD DAAGHKSFIC 950
    ASMQTGFCDW SARYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA 1000
    QQVIQKGITR LDDQIFLNRN PGVPSVVKFH PFTPCIAVAD KDSICFWDWE 1050
    KGEKLDYFHN GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL 1100
    EKNPEMVTAW QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT 1150
    DRETKVQDIP TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC 1200
    RVMTYREHTA WVVKAYLQKH PEGHIVSVSV NGDVRFFDPR MPESVNVMQI 1250
    VKGLTALDIH PQANLIACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG 1300
    AISCLAFHPH WPHLAVGSND YYISVYSVEK RVR 1333
    Length:1,333
    Mass (Da):149,237
    Last modified:April 17, 2007 - v1
    Checksum:i60A3334526AB9085
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118971 mRNA. Translation: AAI18972.1.
    RefSeqiNP_083174.2. NM_028898.2.
    UniGeneiMm.209933.

    Genome annotation databases

    GeneIDi74370.
    KEGGimmu:74370.
    UCSCiuc011yit.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118971 mRNA. Translation: AAI18972.1 .
    RefSeqi NP_083174.2. NM_028898.2.
    UniGenei Mm.209933.

    3D structure databases

    ProteinModelPortali A4FUW1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A4FUW1.

    Protocols and materials databases

    DNASUi 74370.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 74370.
    KEGGi mmu:74370.
    UCSCi uc011yit.1. mouse.

    Organism-specific databases

    CTDi 57521.
    MGIi MGI:1921620. Rptor.

    Phylogenomic databases

    HOVERGENi HBG059496.
    InParanoidi A4FUW1.
    KOi K07204.

    Enzyme and pathway databases

    Reactomei REACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Miscellaneous databases

    ChiTaRSi RPTOR. mouse.
    NextBioi 340575.
    SOURCEi Search...

    Gene expression databases

    Bgeei A4FUW1.
    Genevestigatori A4FUW1.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR12848. PTHR12848. 1 hit.
    Pfami PF14538. Raptor_N. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.

    Entry informationi

    Entry nameiA4FUW1_MOUSE
    AccessioniPrimary (citable) accession number: A4FUW1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)