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A4FUW1

- A4FUW1_MOUSE

UniProt

A4FUW1 - A4FUW1_MOUSE

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Protein
Submitted name:

4932417H02Rik protein

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Display
All None

  • Function
  • Names & Taxonomy
  • Subcellular locationSubcell. location
  • Pathology & BiotechPathol./Biotech
  • PTM / Processing
  • Expression
  • Interaction
  • Structure
  • Family & Domains
  • Sequence
  • Cross-references
  • Publications
  • Entry information
  • Miscellaneous
  • Similar proteins
Top

Functioni

GO - Molecular functioni

  1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
  2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
  3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl

GO - Biological processi

  1. cell growth Source: Ensembl
  2. cellular response to amino acid stimulus Source: Ensembl
  3. cellular response to nutrient levels Source: Ensembl
  4. positive regulation of endothelial cell proliferation Source: Ensembl
  5. positive regulation of protein serine/threonine kinase activity Source: Ensembl
  6. positive regulation of TOR signaling Source: Ensembl
  7. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
  8. regulation of cell size Source: Ensembl
  9. TOR signaling Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
4932417H02Rik proteinImported
Gene namesi
Name:RptorImported
Synonyms:4932417H02RikImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. lysosomal membrane Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. TORC1 complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA4FUW1.

Expressioni

Gene expression databases

BgeeiA4FUW1.
ExpressionAtlasiA4FUW1. baseline and differential.
GenevestigatoriA4FUW1.

Structurei

3D structure databases

ProteinModelPortaliA4FUW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

HOVERGENiHBG059496.
KOiK07204.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A4FUW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SEMLQSPLMG LGEEDEADLT DWNLPLAFMK KRHCEKIEGS KSLAQSWRMK 
        60         70         80         90        100
DRMKTVSVAL VLCLNVGVDP PDVVKTTPCA RLECWIDPLS MGPQKALETI 
       110        120        130        140        150
GANLQKQYEN WQPRARYKQS LDPTVDEVKK LCTSLRRNAK EERVLFHYNG 
       160        170        180        190        200
HGVPRPTVNG EVWVFNKNYT QYIPLSIYDL QTWMGSPSIF VYDCSNAGLI 
       210        220        230        240        250
VKSFKQFALQ REQELEVAAI NPNHPLAQMP LPPSMKNCIQ LAACEAHELL 
       260        270        280        290        300
PMIPDLPADL FTSCLTTPIK IALRWFCMQK CVSLVPGVTL DLIEKIPGRL 
       310        320        330        340        350
NDRRTPLGEL NWIFTAITDT IAWNVLPRDL FQKLFRQDLL VASLFRNFLL 
       360        370        380        390        400
AERIMRSYNC TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ LPTIIEEGTA 
       410        420        430        440        450
FRHSPFFAEQ LTAFQVWLTM GVENRSPPEQ LPIVLQVLLS QVHRLRALDL 
       460        470        480        490        500
LGRFLDLGPW AVSLALSVGI FPYVLKLLQS SARELRPLLV FIWAKILAVD 
       510        520        530        540        550
SSCQADLVKD NGHKYFLSVL ADPYMPAEHR TMTAFILAVI VNSYTTGQEA 
       560        570        580        590        600
CLQGNLIAIC LEQLSDPHPL LRQWVAICLG RIWQNFDSAR WCGVRDSAHE 
       610        620        630        640        650
KLYSLLSDPI PEVRCAAVFA LGTFVGNSAE RTDHSTTIDH NVAMMLAQLI 
       660        670        680        690        700
NDGSPMVRKE LVVALSHLVV QYESNFCTVA LQFMEEEKNY PLPSPAATEG 
       710        720        730        740        750
GSLTPVRDSP CTPRLRSVSS YGNIRAVTTA RNLNKSLQNL SLTEESGSSV 
       760        770        780        790        800
AFSPGNLSTS SSASSTLGSP ENEEYILSFE TIDKMRRVSS YSALNSLIGV 
       810        820        830        840        850
SFNSVYTQIW RVLLHLAADP YPDVSDLAMK VLNSIAYKAT VNARPQRILD 
       860        870        880        890        900
TSSLTQSAPA SPTNKGMHMH QVGGSPPASS TSSCSLTNDV AKQTVSRDLP 
       910        920        930        940        950
SSRPGTAGPT GAQYTPHSHQ FPRTRKMFDK GPDQTTDDAD DAAGHKSFIC 
       960        970        980        990       1000
ASMQTGFCDW SARYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA 
      1010       1020       1030       1040       1050
QQVIQKGITR LDDQIFLNRN PGVPSVVKFH PFTPCIAVAD KDSICFWDWE 
      1060       1070       1080       1090       1100
KGEKLDYFHN GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL 
      1110       1120       1130       1140       1150
EKNPEMVTAW QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT 
      1160       1170       1180       1190       1200
DRETKVQDIP TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC 
      1210       1220       1230       1240       1250
RVMTYREHTA WVVKAYLQKH PEGHIVSVSV NGDVRFFDPR MPESVNVMQI 
      1260       1270       1280       1290       1300
VKGLTALDIH PQANLIACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG 
      1310       1320       1330 
AISCLAFHPH WPHLAVGSND YYISVYSVEK RVR
Length:1,333
Mass (Da):149,237
Last modified:April 17, 2007 - v1
Checksum:i60A3334526AB9085
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118971 mRNA. Translation: AAI18972.1.
RefSeqiNP_083174.2. NM_028898.2.
UniGeneiMm.209933.

Genome annotation databases

GeneIDi74370.
KEGGimmu:74370.
UCSCiuc011yit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
 BC118971 mRNA. Translation: AAI18972.1 .
RefSeqi NP_083174.2. NM_028898.2.
UniGenei Mm.209933.

3D structure databases

ProteinModelPortali A4FUW1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A4FUW1.

Protocols and materials databases

DNASUi 74370.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 74370.
KEGGi mmu:74370.
UCSCi uc011yit.1. mouse.

Organism-specific databases

CTDi 57521.
MGIi MGI:1921620. Rptor.

Phylogenomic databases

HOVERGENi HBG059496.
KOi K07204.

Enzyme and pathway databases

Reactomei REACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Miscellaneous databases

ChiTaRSi Rptor. mouse.
NextBioi 340575.
SOURCEi Search...

Gene expression databases

Bgeei A4FUW1.
ExpressionAtlasi A4FUW1. baseline and differential.
Genevestigatori A4FUW1.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR12848. PTHR12848. 1 hit.
Pfami PF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.
+Additional computationally mapped references.

Entry informationi

Entry nameiA4FUW1_MOUSE
AccessioniPrimary (citable) accession number: A4FUW1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.
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