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Protein
Submitted name:

Met protein

Gene

Met

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1107 – 11071ATPUniRule annotation
Active sitei1201 – 12011Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1081 – 10899ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Met proteinImported
Gene namesi
Name:MetImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96969. Met.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei929 – 95224HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 13781355Sequence analysisPRO_5002667977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1231 – 12311Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1232 – 12321Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1346 – 13461Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1353 – 13531Phosphotyrosine; by autocatalysisUniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiA4FUV6.

PTM databases

iPTMnetiA4FUV6.

Expressioni

Gene expression databases

GenevisibleiA4FUV6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 513488SemaInterPro annotationAdd
BLAST
Domaini1075 – 1342268Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
Contains Sema domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG006348.
KOiK05099.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A4FUV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KAPTVLVPGI LVLLLSLVQR SHGECKEALV KSEMNVNMKY QLPNFTAETP
60 70 80 90 100
IQNVVLHGHH IYLGATNYIY VLNDKDLQKV SEFKTGPVLE HPDCLPCRDC
110 120 130 140 150
SSKANSSGGV WKDNINMALL VDTYYDDQLI SCGSVNRGTC QRHVLPPDNS
160 170 180 190 200
ADIQSEVHCM FSPEEESGQC PDCVVSALGA KVLLSEKDRF INFFVGNTIN
210 220 230 240 250
SSYPPGYSLH SISVRRLKET QDGFKFLTDQ SYIDVLPEFQ DSYPIKYIHA
260 270 280 290 300
FESNHFIYFL TVQKETLDAQ TFHTRIIRFC SVDSGLHSYM EMPLECILTE
310 320 330 340 350
KRRKRSTREE VFNILQAAYV SKPGANLAKQ IGASPSDDIL FGVFAQSKPD
360 370 380 390 400
SAEPVNRSAV CAFPIKYVND FFNKIVNKNN VRCLQHFYGP NHEHCFNRTL
410 420 430 440 450
LRNSSGCEAR SDEYRTEFTT ALQRVDLFMG RLNQVLLTSI STFIKGDLTI
460 470 480 490 500
ANLGTSEGRF MQVVLSRTAH LTPHVNFLLD SHPVSPEVIV EHPSNQNGYT
510 520 530 540 550
LVVTGKKITK IPLNGLGCGH FQSCSQCLSA PYFIQCGWCH NQCVRFDECP
560 570 580 590 600
SGTWTQEICL PAVYKVFPTS APLEGGTVLT ICGWDFGFRK NNKFDLRKTK
610 620 630 640 650
VLLGNESCTL TLSESTTNTL KCTVGPAMSE HFNVSVIISN SRETTQYSAF
660 670 680 690 700
SYVDPVITSI SPRYGPQAGG TLLTLTGKYL NSGNSRHISI GGKTCTLKSV
710 720 730 740 750
SDSILECYTP AQTTSDEFPV KLKIDLANRE TSSFSYREDP VVYEIHPTKS
760 770 780 790 800
FISGGSTITG IGKTLNSVSL PKLVIDVHEV GVNYTVACQH RSNSEIICCT
810 820 830 840 850
TPSLKQLGLQ LPLKTKAFFL LDGILSKHFD LTYVHNPVFE PFEKPVMISM
860 870 880 890 900
GNENVVEIKG NNIDPEAVKG EVLKVGNQSC ESLHWHSGAV LCTVPSDLLK
910 920 930 940 950
LNSELNIEWK QAVSSTVLGK VIVQPDQNFA GLIIGAVSIS VVVLLLSGLF
960 970 980 990 1000
LWMRKRKHKD LGSELVRYDA RVHTPHLDRL VSARSVSPTT EMVSNESVDY
1010 1020 1030 1040 1050
RATFPEDQFP NSSQNGACRQ VQYPLTDLSP ILTSGDSDIS SPLLQNTVHI
1060 1070 1080 1090 1100
DLSALNPELV QAVQHVVIGP SSLIVHFNEV IGRGHFGCVY HGTLLDNDGK
1110 1120 1130 1140 1150
KIHCAVKSLN RITDIEEVSQ FLTEGIIMKD FSHPNVLSLL GICLRSEGSP
1160 1170 1180 1190 1200
LVVLPYMKHG DLRNFIRNET HNPTVKDLIG FGLQVAKGMK YLASKKFVHR
1210 1220 1230 1240 1250
DLAARNCMLD EKFTVKVADF GLARDMYDKE YYSVHNKTGA KLPVKWMALE
1260 1270 1280 1290 1300
SLQTQKFTTK SDVWSFGVLL WELMTRGAPP YPDVNTFDIT IYLLQGRRLL
1310 1320 1330 1340 1350
QPEYCPDALY EVMLKCWHPK AEMRPSFSEL VSRISSIFST FIGEHYVHVN
1360 1370
ATYVNVKCVA PYPSLLPSQD NIDGEGNT
Length:1,378
Mass (Da):153,460
Last modified:April 17, 2007 - v1
Checksum:iBE941D9D82E49F0B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117969 mRNA. Translation: AAI17970.1.
RefSeqiNP_032617.2. NM_008591.2.
UniGeneiMm.86844.

Genome annotation databases

GeneIDi17295.
KEGGimmu:17295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117969 mRNA. Translation: AAI17970.1.
RefSeqiNP_032617.2. NM_008591.2.
UniGeneiMm.86844.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079324.

PTM databases

iPTMnetiA4FUV6.

Proteomic databases

PaxDbiA4FUV6.

Protocols and materials databases

DNASUi17295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17295.
KEGGimmu:17295.

Organism-specific databases

CTDi4233.
MGIiMGI:96969. Met.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG006348.
KOiK05099.

Miscellaneous databases

ChiTaRSiMet. mouse.
SOURCEiSearch...

Gene expression databases

GenevisibleiA4FUV6. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA4FUV6_MOUSE
AccessioniPrimary (citable) accession number: A4FUV6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.